Cooperative Agreement 2507312
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) Project Grant award of $274,918 to Cascade Biocatalysts Inc. will fund research and development to demonstrate the commercial feasibility and scalability of a patent-pending approach for stabilizing enzymes through engineered polymer-enzyme interactions. The goal is to enable environmentally sustainable, low-carbon chemical manufacturing processes that utilize enzymes as catalysts, which can decrease...
- The National Science Foundation (NSF) awarded a $2,526,095 Cooperative Agreement to Arzeda Corp, a biotechnology company based in Seattle, Washington, under the NSF Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084). The project aims to transform the electrochemical conversion of carbon dioxide (CO2) to methanol by developing a highly efficient, cell-free enzymatic cascade system. The research will integrate AI-driven enzyme design, synthetic chemistry, and advanced...
- This Cooperative Agreement award from the National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) program provides $2,233,515 to support a project by Arzeda Corp to transform the production of acrylates through the use of AI-designed enzymes and non-natural cofactors. The project aims to develop a scalable, cost-effective, and cell-free biocatalytic process for producing methylene butyrolactone (MBL), a bio-based acrylate monomer. This will involve engineering...
- The National Science Foundation (NSF) awarded a $2,375,361 Cooperative Agreement to Koliber Biosciences Inc. under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program. The project aims to develop computational tools that leverage artificial intelligence and machine learning to design improved protein "transporter" molecules. These transporter proteins control the movement of valuable chemicals in and out of cells, which is a critical limitation in microbial...
- This Cooperative Agreement award, valued at $1,000,000, was made by the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) to Birch Biosciences LLC, a for-profit biotechnology company. The goal of the project is to develop high-performance engineered enzymes that can efficiently break down polyethylene terephthalate (PET) plastic into its chemical building blocks, terepthalic acid and ethylene glycol. This innovative enzymatic...
- This $2,996,108 Cooperative Agreement awarded by the National Science Foundation (NSF) under its Technology, Innovation, and Partnerships (CFDA 47.084) program aims to develop more efficient cell-free biomanufacturing processes. The project is creating membraneless compartmentalization techniques using custom-designed enzymes and innovative materials. This approach enables the simultaneous execution of multiple redox reactions required to produce valuable chiral chemicals, overcoming the...
- This $2,572,498 Cooperative Agreement award, funded by the National Science Foundation (CFDA 47.084 - Technology, Innovation, and Partnerships program), aims to develop new bioplastics with diverse properties. The project will computationally design complex enzymes within engineered bacteria to produce novel, sturdy bioplastics that can withstand high temperatures and be easily recycled or biodegraded. Key goals include strengthening supply chain resilience through the bioeconomy, advancing...
- This National Science Foundation (NSF) Cooperative Agreement award of $1,249,319, provided under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program, supports the development and optimization of a novel synthetic polymer-based technology for encapsulating biomolecules to enable ambient temperature storage. The project aims to develop automated, scalable processes for efficient sample preservation, focusing on optimizing the polymer chemistry, establishing robust...
- This National Science Foundation (NSF) Technology, Innovation, and Partnerships (CFDA 47.084) award provides $274,727 to Weka Biosciences LLC, a woman-owned small business, to develop a novel microbial process for creating a synthetic sugar polymer for use in chiral chromatography. The goal is to produce a more reliable and efficient polymer material to enhance the precision of drug manufacturing and contribute to safer, more effective medications. The 12-month project will focus on...
- This SBIR Phase I award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (TIP) program (CFDA 47.084) provides $275,000 to Caravel Bio, Inc. to develop a novel synthetic biology platform for high-throughput directed evolution of spore-displayed enzymes. The project aims to create customizable enzyme solutions for industrial biocatalyst applications by improving key properties like enzyme activity, stability, and loading density. The technology uses a...
The National Science Foundation (NSF) awarded a $1,250,000 Cooperative Agreement under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Cascade Biocatalysts Inc. This funding supports the development of a proprietary polymerization technique to create polymer brushes that stabilize enzymes for use in advanced chemical manufacturing processes. The key objectives are to enable a lower-cost and scalable solution for biomanufacturing by increasing the stability and lifespan of enzymes used to catalyze chemical processes. This will address challenges with scaling up enzyme-based production to 100 kg batch sizes and enable further integration with customer enzyme processes. The project aims to reduce unit costs through process intensification and advanced process monitoring, ultimately increasing the adoption of enzymes in multiple industries including pharmaceuticals, flavors, and fragrances. The innovative enzyme immobilization technology has the potential to contribute to onshoring critical chemical production and strengthening domestic supply chain resilience.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 8/18/25 |