Center for Substance Abuse Prevention Projects of Regional and National Significance
Active
- Assistance listing
- 93.492
- Agency
-
Substance Abuse and Mental Health Services Administration
Department of Health and Human Services
- Grant awards
- 103 $94,424,517 in federal obligations
Program facts
- Assistance type
-
- Project Grant
- Treasury account
-
- 75-1365-0-1-551
- More information
Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.
About this program
The Department of Health and Human Services Substance Abuse and Mental Health Services Administration (SAMHSA) through its Center for Substance Use Prevention (CSAP) funds community-based substance use prevention and early intervention projects serving states, tribes, and communities under Assistance Listing 93.492, with 103 Project Grants totaling $94.4 million in federal obligations as of the most recent award on September 30, 2026.
The program funds concrete prevention and early intervention activities: evidence-based youth substance use prevention curricula and school-based programs; community coalitions addressing youth access to alcohol, cannabis, tobacco, and other substances; parent and family engagement initiatives; youth leadership and peer mentoring; environmental prevention strategies including retail compliance monitoring and responsible beverage service training; and capacity building to strengthen coordination among schools, law enforcement, healthcare providers, and community organizations. Recent awards fund projects ranging from youth-focused underage drinking prevention in rural Appalachian counties through evidence-based programs like Too Good for Drugs and Lifeskills Training to statewide strategic prevention frameworks targeting methamphetamine use in young adults and building comprehensive prevention infrastructure across multiple counties and tribal territories.
Awards are exclusively Project Grants, predominantly in the $60,000 to $250,000 range, with larger capacity-building awards reaching $425,000 to $600,000 and a few mega-awards for statewide initiatives at $2 million. SAMHSA is the sole funding agency. Recent activity accelerated sharply: five awards in 2024, 22 in 2025, and 76 through September 2026, demonstrating sustained and expanding grant deployment.
Three matching NOFOs closed recently after hitting the 60-application cap: Sober Truth on Preventing Underage Drinking Act Grants (SP-26-001, due July 15, 2026), Strategic Prevention Framework–Partnerships for Success for Communities/Tribes (SP-26-002, due July 10, 2026), and Strategic Prevention Framework–Partnerships for Success for States (SP-26-003, due July 15, 2026). A Tribal Behavioral Health Substance Use Prevention opportunity (SP-26-004) closed July 13, 2026, serving federally recognized tribal governments and tribal organizations. No open solicitations are currently posted.
Objective and description
- Objective
The Center for Substance Use Prevention (CSAP) projects for regional and national significance support states, tribes and communities through grants and cooperative agreements. CSAP programs support prevention and early intervention strategies to red
- Description
The Center for Substance Use Prevention (CSAP) projects for regional and national significance support states, tribes and communities through grants and cooperative agreements. CSAP programs support prevention and early intervention strategies to reduce the impact of substance use in America's communities. This is achieved by (1) protecting and strengthening access to high quality and affordable healthcare; (2) expanding access to comprehensive, community-based, innovative, and prevention programs and healthcare services; and (3) enhancing youth-focused promotion of healthy behaviors to reduce the occurrence of preventable injury, illness, and death.
Eligibility
- Applicant eligibility
State (includes District of Columbia, U.S. Territories, and Pacific Jurisdictions, public institutions of higher education and hospitals), Local (includes State-designated Indian Tribes, excludes institutions of higher education and hospitals, Sponsored organization, Public nonprofit institution/organization (includes institutions of higher education and hospitals), Other public institution/organization, Federally Recognized Indian Tribal Governments, Private nonprofit institution/organization (includes institutions of higher education and hospitals), Quasi-public nonprofit institution/organization, Native American Organizations (includes Indian groups, cooperatives, corporations, partnerships, associations) Public organizations, such as units of State and local governments and to domestic private nonprofit organizations such as community-based organizations, universities, colleges and hospitals. State educational agencies, local educational agencies, Indian Tribes (as defined in section 4 of the Indian Self-Determination and Education Assistance Act) or their tribal educational agencies, a school operated by the Bureau of Indian Education, a Regional Corporation, or a Native Hawaiian educational organization.
- Beneficiary eligibility
The eligible beneficiaries include State and US Territories, Local government, Tribal government (federally recognized tribes, tribal organizations), State Administrative Agencies, service providers, community and nonprofit organizations, universities and colleges, research institutions, training and technical assistance providers, and Grant recipients and individuals served by the grant projects.
How to apply
- Criteria for selecting proposals
A merit review is conducted on the applications submitted, which includes a description of the proposed project.
- Award procedure
Applications are awarded directly by SAMHSA to the applicant organization after a number of considerations, including but not limited to merit review, program analysis, and concurrence by the CSAP National Advisory Council.
- Renewals
Determined as part of the NOFO
Grant opportunities
| Opportunity | Status | Posted | Applications due |
|---|---|---|---|
| Tribal Behavioral Health Substance Use Prevention | Closed | ||
| Strategic Prevention Framework - Partnerships for Success for Communities/Tribes | Closed | ||
| Sober Truth on Preventing Underage Drinking Act Grants | Closed | ||
| Strategic Prevention Framework - Partnerships for Success for States | Closed |
Grant awards
Latest 10 of 103 listed here. See the rest on GovTribe.
Top recipients by federal obligations
| Rank | Recipient | Federal obligations | Share |
|---|---|---|---|
| 1 | Wake Forest University Health Sciences | $7,306,919 | 8% |
| 2 | Washington State University | $7,212,932 | 8% |
| 3 | University Of Wisconsin System | $7,091,010 | 8% |
| 4 | University Of Wyoming | $6,349,626 | 7% |
| 5 | University Of Oklahoma | $4,645,151 | 5% |
| 6 | Florida Atlantic University | $3,239,089 | 3% |
| 7 | Westcare Wisconsin, Inc. | $2,400,715 | 3% |
| 8 | Child Health And Development Institute Of Connecticut, Inc. | $2,364,089 | 3% |
| 9 | Southern Plains Tribal Health Board Foundation | $2,239,089 | 2% |
| 10 | Massachusetts Department Of Public Health | $2,000,000 | 2% |
10 of 99 recipients listed here. See the rest on GovTribe.
Federal obligations by fiscal year
| Fiscal year | Federal obligations |
|---|---|
| FY2026 | $29,926,739 |
Quick answers
What is Assistance Listing 93.492?
Assistance Listing 93.492 is Center for Substance Abuse Prevention Projects of Regional and National Significance, a federal grant program run by Substance Abuse and Mental Health Services Administration (Department of Health and Human Services).
What is the CFDA number for Center for Substance Abuse Prevention Projects of Regional and National Significance?
Its CFDA number is 93.492: Assistance Listing numbers were called CFDA numbers before 2018.
How much funding has Assistance Listing 93.492 awarded?
103 grant awards under 93.492 have obligated $94,424,517 in federal funds to 99 recipients.
Who receives the most funding from 93.492?
The recipients obligated the most under Center for Substance Abuse Prevention Projects of Regional and National Significance are Wake Forest University Health Sciences ($7,306,919), Washington State University ($7,212,932) and University Of Wisconsin System ($7,091,010).
Are there open grant opportunities under 93.492?
No opportunity listed under 93.492 is open now. The latest, Tribal Behavioral Health Substance Use Prevention, was posted on April 20, 2026.
On GovTribe
See this program's full record
- Every grant award and opportunity under it
- Funding by recipient, agency and assistance type
- Alerts for new opportunities
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