Strategic Prevention Framework - Partnerships for Success for States

The Substance Abuse and Mental Health Services Administration is soliciting applications for the Strategic Prevention Framework—Partnerships for Success for States program, with an application due date of July 15, 2026, to fund community-based substance use prevention services that strengthen protective factors, reduce risk factors, build resilience, and promote well-being while expanding prevention provider capacity to deliver evidence-based, evidence-informed, and community-defined prevention strategies.

Eligible applicants include states (including the District of Columbia, U.S. territories, and Pacific jurisdictions), local governments, federally recognized Indian tribal governments, institutions of higher education, public and private nonprofit organizations, quasi-public nonprofit organizations, and Native American organizations. The program also benefits state and local educational agencies, schools operated by the Bureau of Indian Education, and regional corporations.

Awards are made directly by SAMHSA following merit review, program analysis, and concurrence by the CSAP National Advisory Council. Recipients must retain records for three years; retention extends beyond three years if final audits remain incomplete or findings unresolved.

The program operates under CFDA 93.492 (Center for Substance Abuse Prevention Projects of Regional and National Significance) and advances three primary objectives: protecting and strengthening access to high-quality and affordable healthcare; expanding access to comprehensive, community-based, and innovative prevention programs and healthcare services; and promoting healthy behaviors among youth to reduce preventable injury, illness, and death.

Eligible beneficiaries include states, U.S. territories, local governments, tribal governments, state administrative agencies, service providers, community and nonprofit organizations, universities and colleges, research institutions, training and technical assistance providers, grant recipients, and individuals served by grant projects.