Scientific Research - Combating Weapons of Mass Destruction

Active

Assistance listing
12.351
Agency
Grant awards
852 $1,174,560,682 in federal obligations

Program facts

Assistance types
  • Project Grant
  • Cooperative Agreement
  • Block Grant
Treasury account
  • 97-0400-3-4-000
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Defense Threat Reduction Agency (DTRA) funds basic, applied, and advanced research supporting counter-weapons of mass destruction capabilities under CFDA 12.351, with the most recent award issued on June 1, 2026. The program supports research at educational institutions, non-profit organizations, and commercial firms pursuing fundamental knowledge and capabilities to identify, counter, reduce, or eliminate chemical, biological, radiological, nuclear, and high-yield explosive threats, including improvised threats.

The program has issued 852 awards since 2006, distributing $1.17 billion in federal obligated dollars. Award velocity has declined significantly: the past five years show 38 awards (2022), 6 (2023), 14 (2024), 8 (2025), and 7 (2026 through June). The portfolio is predominantly Project Grants (814 awards, 96 percent) with a smaller share of Block Grants (36 awards, 4 percent) and minimal Cooperative Agreements (2 awards, less than 1 percent). DTRA is the sole funding source across all awards.

Recent awards span medical countermeasures, materials science, diagnostics, and detection. Representative examples include Project Grant HDTRA12610002 ($999,996) for polymeric/protein nanoparticle platforms targeting drug delivery to neurons using AI/ML guidance for synthesis; Project Grant HDTRA12410019 ($1.419 million) for biofunctionalized self-propelled micromotors for active decontamination; Project Grant HDTRA12310026 ($2.5 million) for defining toxin recognition and computational anti-toxin design principles; and Project Grant HDTRA12210038 ($2.492 million) for epidemiologic and molecular characterization of foot-and-mouth disease in Armenia and Georgia. Award magnitudes range from under $100 thousand to approximately $2.5 million.

Two major Broad Agency Announcements are currently open. The Fundamental Research to Counter Weapons of Mass Destruction BAA (HDTRA1-25-S-0001) posted October 1, 2024, with a closing date of September 30, 2034; Amendment 1 added Thrust Area 1 Topics A1-A7 with pre-application white papers due February 7, 2025, and Amendment 2 added Topics B1-B6 with white paper deadline March 2, 2026. The Biological Threat Reduction with Global Partners BAA (HDTRA1-24-S-0002) posted May 15, 2024, and remains open through April 28, 2029. Eligibility extends to higher education institutions (public and private), non-profit organizations, small businesses, for-profit organizations, and other entity types; awards are not made to individuals.

Objective and description

Objective

To support and stimulate basic, applied and advanced research at educational or research institutions, non-profit organizations, and commercial firms, which support the advancement of fundamental knowledge and understanding of the sciences with an em

Description

DTRA safeguards America and its allies from weapons of mass destruction (WMD) and provides capabilities to reduce, eliminate, and counter the threat and effects from chemical, biological, radiological, nuclear, and high yield explosives. DTRA seeks to identify, adopt, and adapt emerging, existing and revolutionary sciences that may demonstrate high payoff potential to Counter-WMD threats, including improvised threats. This endeavor combines the fundamental research, educational program, or other effort needs appropriate for basic or applied research funding of DTRA and other DoD interests.

Eligibility

Applicant eligibility

As stated in individual program BAAs. Generally, competitions are open to private and public educational accredited institutions of higher education that carry out science and engineering research and/or related science and engineering education on a non-profit basis. Some awards are made to other non-profit and for profit organizations that conduct research. Awards are not made to individuals.

Beneficiary eligibility

See above.

Uses of assistance

Uses and restrictions are specified in individual program BAAs and award documents issued by and codified regulations applicable to awards. These are submitted at the time of proposal or prior to award, as specified by executive agents. Fee is not an allowable cost.

Use restrictions

Fee is not an allowable cost. Expenditures must be in scope of the award, statement of work, and terms and conditions.

Length and time phasing of assistance

Since this is a research and technology program, the assistance is generally for the period of performance as stated in the individual grant, agreement or TIA. Funding is usually provided incrementally in accordance with a payment schedule contained in the award document. Grants are normally a base period and option years up to five total years.

How to apply

Criteria for selecting proposals

Generally, the principal evaluation and selection criteria are the technical or socio-economic merits of the proposal and potential long term contributions of DTRA's specific mission. Other selection criteria vary with the nature of the specific research or research-related activity. Typically, these include the qualifications, capabilities, and experience of the proposed Principal Investigator and/or key personnel who are critical in achieving the proposal objectives; adequacy of current or planned facilities, and equipment; and reasonableness and realism of the proposed costs.

Award procedure

Award decisions are based on evaluations of proposals using peer and/or scientific review. Evaluation criteria are contained in the relevant BAA. If selected for award, the proposal is the basis for the award document and the applicant agrees to perform the research or research related activities described therein.

Deadlines

Review the appropriate funding announcement for due date and deadline information.

Time to approval or disapproval

Award times will be identified in the relevant BAA. Typically, decisions are made within 90-120 days of receipt of proposal for which funding is authorized.

Renewals

Re-application with new proposals is permitted.

Grant opportunities

Opportunity Status Posted Applications due
Fundamental Research to Counter Weapons of Mass Destruction HDTRA1-25-S-0001 Open
Biological Threat Reduction with Global Partners Broad Agency Announcement (BAA) HDTRA1-24-S-0002 Open
Materials Science in Extreme Environments University Research Alliance (MSEE-URA) HDTRA1-19-S-0003-MSEE-URA Closed
Interaction of Ionizing Radiation with Matter University Research Alliance (IIRM-URA) HDTRA1-19-S-0004-IIRM-URA Closed
Adaptive Signature Discovery University Research Alliance (ASD-URA) HDTRA1-19-S-0002-ASD-URA Closed
DRAFT-Adaptive Signature Discovery University Research Alliance (ASD-URA) DRAFT-HDTRA1-19-S-0002-ASD-URA Closed
DRAFT-Materials Science in Extreme Environments University Research Alliance (MSEE-URA) DRAFT-HDTRA1-19-S-0003-MSEE-URA Closed
DRAFT-Interaction of Ionizing Radiation with Matter University Research Alliance (IIRM-URA) DRAFT-HDTRA1-19-S-0004-IIRM-URA Closed
Fundamental Research to Counter Weapons of Mass Destruction HDTRA1-14-24-FRCWMD-BAA Closed
FY2011 - 2016 Basic Research for Combating Weapons of Mass Destruction (C-WMD) Broad Agency Announcement (BAA) HDTRA1-11-16-BRCWMD-BAA Closed

Grant awards

Award Recipient Federal obligations Awarded
This proposal seeks to deliver capabilities that accelerate the discovery, development, and manufacturing of medical… HDTRA12610006 The Leland Stanford Junior University $500,000
Execute an integrated research program to develop a biomanufacturing platform for on-demand small-scale synthesis of… HDTRA12610010 Massachusetts Institute Of Technology $500,000
Identify spiroligomer (molecular lego) based on catalysts that hydrolyze nerve agents from 1.5- million-member… HDTRA12610001 Ladder Bio, Inc. $488,999
The multidisciplinary research will increase knowledge and improve capabilities for development of new or improved… HDTRA12610004 Georgia TECH Research Corp $629,669
This effort encompasses research to define the molecular recognition principles by which two diverse toxin sponge… HDTRA12610008 The Regents Of The University Of California. San Francisco $668,055
The proposal leverages a novel polymeric/protein nanoparticles (PNP) platform that will be used to deliver an… HDTRA12610002 Battelle Memorial Institute $999,996
The purpose of this grant is for UW to develop strategies for rapid, scalable synthesis for ZR-mofs with controllable… HDTRA12610005 University Of Washington $199,988
The university will organize research efforts along three complementary and synergistic research tasks, each with… HDTRA12610007 University Of Washington $500,000
The objective of this project is to address key challenges in existing chemical standoff sensing techniques through… HDTRA12610003 Carnegie-Mellon University $701,966
To create spatiotemporal inflammation associated with agent exposure HDTRA12510005 The Regents Of The University Of Colorado $824,588

Latest 10 of 852 listed here. See the rest on GovTribe.

Top recipients by federal obligations

Rank Recipient Federal obligations Share
1 The Pennsylvania State University $70,576,348 6%
2 The Johns Hopkins University $62,889,220 5%
3 Ecohealth Alliance Inc. $33,624,153 3%
4 Massachusetts Institute Of Technology $32,281,388 3%
5 University Of Washington $28,921,742 2%
6 University Of Maryland, College Park $27,575,104 2%
7 University Of New Mexico $25,372,660 2%
8 Georgia TECH Research Corp $24,539,297 2%
9 University Of California, LOS Angeles $24,517,320 2%
10 Vanderbilt University $24,441,799 2%

10 of 240 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $25,567,998
FY2025 $25,717,218
FY2024 $48,362,331
FY2023 $50,680,823
FY2022 $70,742,562
FY2021 $73,972,814
FY2020 $100,022,054
FY2019 $85,030,935
FY2018 $89,218,790
FY2017 $81,723,226
FY2016 $69,694,516
FY2015 $66,512,267
FY2014 $64,710,644
FY2013 $64,133,977
FY2012 $65,598,085
FY2011 $71,123,825
FY2010 $45,415,197
FY2009 $27,302,557
FY2008 $31,223,748
FY2007 $16,451,636
Show all 20

Quick answers

What is Assistance Listing 12.351?

Assistance Listing 12.351 is Scientific Research - Combating Weapons of Mass Destruction, a federal grant program run by Defense Threat Reduction Agency (Department of Defense).

What is the CFDA number for Scientific Research - Combating Weapons of Mass Destruction?

Its CFDA number is 12.351: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 12.351 awarded?

852 grant awards under 12.351 have obligated $1,174,560,682 in federal funds to 240 recipients.

Who receives the most funding from 12.351?

The recipients obligated the most under Scientific Research - Combating Weapons of Mass Destruction are The Pennsylvania State University ($70,576,348), The Johns Hopkins University ($62,889,220) and Ecohealth Alliance Inc. ($33,624,153).

How much did 12.351 obligate in fiscal year 2025?

Grants under 12.351 obligated $25,717,218 in federal funds in fiscal year 2025.

Are there open grant opportunities under 12.351?

2 listed opportunities under 12.351 are open or forecasted. The latest, Fundamental Research to Counter Weapons of Mass Destruction, was posted on October 1, 2024.

On GovTribe

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