Scientific Research - Combating Weapons of Mass Destruction
Active
- Assistance listing
- 12.351
- Agency
-
Defense Threat Reduction Agency
Department of Defense
- Grant awards
- 852 $1,174,560,682 in federal obligations
Program facts
- Assistance types
-
- Project Grant
- Cooperative Agreement
- Block Grant
- Treasury account
-
- 97-0400-3-4-000
- More information
Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.
About this program
The Defense Threat Reduction Agency (DTRA) funds basic, applied, and advanced research supporting counter-weapons of mass destruction capabilities under CFDA 12.351, with the most recent award issued on June 1, 2026. The program supports research at educational institutions, non-profit organizations, and commercial firms pursuing fundamental knowledge and capabilities to identify, counter, reduce, or eliminate chemical, biological, radiological, nuclear, and high-yield explosive threats, including improvised threats.
The program has issued 852 awards since 2006, distributing $1.17 billion in federal obligated dollars. Award velocity has declined significantly: the past five years show 38 awards (2022), 6 (2023), 14 (2024), 8 (2025), and 7 (2026 through June). The portfolio is predominantly Project Grants (814 awards, 96 percent) with a smaller share of Block Grants (36 awards, 4 percent) and minimal Cooperative Agreements (2 awards, less than 1 percent). DTRA is the sole funding source across all awards.
Recent awards span medical countermeasures, materials science, diagnostics, and detection. Representative examples include Project Grant HDTRA12610002 ($999,996) for polymeric/protein nanoparticle platforms targeting drug delivery to neurons using AI/ML guidance for synthesis; Project Grant HDTRA12410019 ($1.419 million) for biofunctionalized self-propelled micromotors for active decontamination; Project Grant HDTRA12310026 ($2.5 million) for defining toxin recognition and computational anti-toxin design principles; and Project Grant HDTRA12210038 ($2.492 million) for epidemiologic and molecular characterization of foot-and-mouth disease in Armenia and Georgia. Award magnitudes range from under $100 thousand to approximately $2.5 million.
Two major Broad Agency Announcements are currently open. The Fundamental Research to Counter Weapons of Mass Destruction BAA (HDTRA1-25-S-0001) posted October 1, 2024, with a closing date of September 30, 2034; Amendment 1 added Thrust Area 1 Topics A1-A7 with pre-application white papers due February 7, 2025, and Amendment 2 added Topics B1-B6 with white paper deadline March 2, 2026. The Biological Threat Reduction with Global Partners BAA (HDTRA1-24-S-0002) posted May 15, 2024, and remains open through April 28, 2029. Eligibility extends to higher education institutions (public and private), non-profit organizations, small businesses, for-profit organizations, and other entity types; awards are not made to individuals.
Objective and description
- Objective
To support and stimulate basic, applied and advanced research at educational or research institutions, non-profit organizations, and commercial firms, which support the advancement of fundamental knowledge and understanding of the sciences with an em
- Description
DTRA safeguards America and its allies from weapons of mass destruction (WMD) and provides capabilities to reduce, eliminate, and counter the threat and effects from chemical, biological, radiological, nuclear, and high yield explosives. DTRA seeks to identify, adopt, and adapt emerging, existing and revolutionary sciences that may demonstrate high payoff potential to Counter-WMD threats, including improvised threats. This endeavor combines the fundamental research, educational program, or other effort needs appropriate for basic or applied research funding of DTRA and other DoD interests.
Eligibility
- Applicant eligibility
As stated in individual program BAAs. Generally, competitions are open to private and public educational accredited institutions of higher education that carry out science and engineering research and/or related science and engineering education on a non-profit basis. Some awards are made to other non-profit and for profit organizations that conduct research. Awards are not made to individuals.
- Beneficiary eligibility
See above.
- Uses of assistance
Uses and restrictions are specified in individual program BAAs and award documents issued by and codified regulations applicable to awards. These are submitted at the time of proposal or prior to award, as specified by executive agents. Fee is not an allowable cost.
- Use restrictions
Fee is not an allowable cost. Expenditures must be in scope of the award, statement of work, and terms and conditions.
- Length and time phasing of assistance
Since this is a research and technology program, the assistance is generally for the period of performance as stated in the individual grant, agreement or TIA. Funding is usually provided incrementally in accordance with a payment schedule contained in the award document. Grants are normally a base period and option years up to five total years.
How to apply
- Criteria for selecting proposals
Generally, the principal evaluation and selection criteria are the technical or socio-economic merits of the proposal and potential long term contributions of DTRA's specific mission. Other selection criteria vary with the nature of the specific research or research-related activity. Typically, these include the qualifications, capabilities, and experience of the proposed Principal Investigator and/or key personnel who are critical in achieving the proposal objectives; adequacy of current or planned facilities, and equipment; and reasonableness and realism of the proposed costs.
- Award procedure
Award decisions are based on evaluations of proposals using peer and/or scientific review. Evaluation criteria are contained in the relevant BAA. If selected for award, the proposal is the basis for the award document and the applicant agrees to perform the research or research related activities described therein.
- Deadlines
Review the appropriate funding announcement for due date and deadline information.
- Time to approval or disapproval
Award times will be identified in the relevant BAA. Typically, decisions are made within 90-120 days of receipt of proposal for which funding is authorized.
- Renewals
Re-application with new proposals is permitted.
Grant opportunities
Grant awards
Latest 10 of 852 listed here. See the rest on GovTribe.
Top recipients by federal obligations
| Rank | Recipient | Federal obligations | Share |
|---|---|---|---|
| 1 | The Pennsylvania State University | $70,576,348 | 6% |
| 2 | The Johns Hopkins University | $62,889,220 | 5% |
| 3 | Ecohealth Alliance Inc. | $33,624,153 | 3% |
| 4 | Massachusetts Institute Of Technology | $32,281,388 | 3% |
| 5 | University Of Washington | $28,921,742 | 2% |
| 6 | University Of Maryland, College Park | $27,575,104 | 2% |
| 7 | University Of New Mexico | $25,372,660 | 2% |
| 8 | Georgia TECH Research Corp | $24,539,297 | 2% |
| 9 | University Of California, LOS Angeles | $24,517,320 | 2% |
| 10 | Vanderbilt University | $24,441,799 | 2% |
10 of 240 recipients listed here. See the rest on GovTribe.
Federal obligations by fiscal year
| Fiscal year | Federal obligations |
|---|---|
| FY2026 | $25,567,998 |
| FY2025 | $25,717,218 |
| FY2024 | $48,362,331 |
| FY2023 | $50,680,823 |
| FY2022 | $70,742,562 |
| FY2021 | $73,972,814 |
| FY2020 | $100,022,054 |
| FY2019 | $85,030,935 |
| FY2018 | $89,218,790 |
| FY2017 | $81,723,226 |
| FY2016 | $69,694,516 |
| FY2015 | $66,512,267 |
| FY2014 | $64,710,644 |
| FY2013 | $64,133,977 |
| FY2012 | $65,598,085 |
| FY2011 | $71,123,825 |
| FY2010 | $45,415,197 |
| FY2009 | $27,302,557 |
| FY2008 | $31,223,748 |
| FY2007 | $16,451,636 |
Show all 20
Quick answers
What is Assistance Listing 12.351?
Assistance Listing 12.351 is Scientific Research - Combating Weapons of Mass Destruction, a federal grant program run by Defense Threat Reduction Agency (Department of Defense).
What is the CFDA number for Scientific Research - Combating Weapons of Mass Destruction?
Its CFDA number is 12.351: Assistance Listing numbers were called CFDA numbers before 2018.
How much funding has Assistance Listing 12.351 awarded?
852 grant awards under 12.351 have obligated $1,174,560,682 in federal funds to 240 recipients.
Who receives the most funding from 12.351?
The recipients obligated the most under Scientific Research - Combating Weapons of Mass Destruction are The Pennsylvania State University ($70,576,348), The Johns Hopkins University ($62,889,220) and Ecohealth Alliance Inc. ($33,624,153).
How much did 12.351 obligate in fiscal year 2025?
Grants under 12.351 obligated $25,717,218 in federal funds in fiscal year 2025.
Are there open grant opportunities under 12.351?
2 listed opportunities under 12.351 are open or forecasted. The latest, Fundamental Research to Counter Weapons of Mass Destruction, was posted on October 1, 2024.
On GovTribe
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