Identify spiroligomer (molecular lego) based on catalysts that hydrolyze nerve agents from 1.5- million-member library of metalloenzyme-like hydrolytic active sites and improve them

Active Project Grant Awarded Last action

Award ID
HDTRA12610001
Recipient
Awarding agency
Obligated
$488,999

Award facts

Completion date 10% complete
Place of performance
Penllyn, PA 19422, USA

Award details come from USAspending.gov.

About this award

The Defense Threat Reduction Agency awarded $488,999 to Ladder Bio, Inc. on April 13, 2026, under the Scientific Research - Combating Weapons of Mass Destruction program (CFDA 12.351) to identify spiroligomer-based catalysts that hydrolyze nerve agents from a 1.5-million-member library of metalloenzyme-like hydrolytic active sites and improve them.

Ladder Bio, Inc. operates as a division of Thirdlaw Molecular Inc. Work is performed in Penllyn, Pennsylvania. The period of performance runs from April 13, 2026, through April 12, 2031. This is a Project Grant, a form of assistance funding supporting basic, applied, and advanced research at educational or research institutions, non-profit organizations, and commercial firms to advance fundamental knowledge in support of DTRA's mission to counter weapons of mass destruction threats, including chemical threats.

Subawards

Subrecipient Amount Awarded
Temple University-Of The Commonwealth System Of Higher Education Establish and optimize FACS-based screening workflows for the tagged catalyst library. Sort and recover enriched candidate populations and hit fractions… $455,079

Quick answers

Who received award HDTRA12610001?

HDTRA12610001 was awarded to Ladder Bio, Inc. by Defense Threat Reduction Agency (Department of Defense) on April 13, 2026.

How much is award HDTRA12610001 worth?

$488,999 has been obligated on HDTRA12610001.

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