CoasterChase
Closed Posted
- Opportunity number
- HR001125S0014
- Agency
-
Defense Advanced Research Projects Agency
Department of Defense
- Applications due
- Award size
- Not on record
Opportunity facts
- Assistance listings
- Funding instrument
- Cooperative Agreement, Procurement Contract
- Category
-
- Science and Technology and other Research and Development
- Eligible applicants
-
- Other
- Points of contact
-
- Pedro Irazoqui coasterchase@darpa.mil
- Full announcement
Opportunity details come from Grants.gov. Updated .
About this opportunity
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the CoasterChase program, seeking to develop a multimodal, ingestible sensing and stimulation platform that can monitor and modulate biomarkers of acute stress within the small intestine. The program aims to leverage emerging neuromodulation technologies to selectively target neurons in the enteric nervous system and alter the body's stress response. Key contract requirements include developing revolutionary approaches in enteric neuromodulation, ingestible electronics, and stress response modulation, with a specific exclusion of research that only provides evolutionary improvements to existing technologies. Evaluation criteria will likely focus on the innovativeness of the proposed approach, technical feasibility, and potential impact on defense capabilities. Critical dates include a proposal abstract due on July 24, 2025, and full proposals due on August 28, 2025, with an anticipated project start in January 2026.
The program is funded up to $25 million, with potential funding instruments including cooperative agreements, procurement contracts, and other transaction agreements. The research is structured in two phases: a 12-month base period focusing on enteric neuronal target identification and platform development, followed by a 12-month optional period for integration and large-animal behavioral studies. Research must exclusively use large animal models (excluding non-human primates, cats, and dogs) and cannot involve human subjects, pharmacological approaches, or genetic material delivery. The program welcomes proposals from universities, small businesses, research centers, and both U.S. and non-U.S. organizations, with a focus on fundamental research that can develop transformative defense capabilities in biomedical technologies.
Synopsis
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals that leverage a novel understanding of the enteric nervous system as well as emerging neuromodulation technologies to selectively target neurons in the small intestine and alter the body's stress response. The CoasterChase program aims to develop a multimodal, ingestible, sensing and stimulation platform for use in monitoring and modulating biomarkers of acute stress from within the small intestine. Proposed research should investigate innovative approaches that enable revolutionary advances in enteric neuromodulation and sensing, ingestible electronics, and modulation of the stress response. Specifically excluded is research that primarily results in evolutionary improvements to the existing state of practice.
Files
| File | Type | Posted |
|---|---|---|
| HR001125S0014-Amendment-01.pdf | ||
| Attachment_E_Cost_Proposal_Spreadsheet__UPDATE_.xlsx | XLSX spreadsheet | |
| Attachment_C_Proposal_Volume_1_Instructions_Template.pdf | ||
| Attachment_F_Risk_Assessment_Matrix_Instructions_Template.pptx | PPTX presentation | |
| Attachment_E_Cost_Proposal_Spreadsheet_v3.xlsx | XLSX spreadsheet | |
| Attachment_D_Proposal_Volume_2_Instructions_Template.docx | DOCX document | |
| Attachment_B_Proposal_Summary_Slide_Instructions_Template.pptx | PPTX presentation | |
| HR001125S0014.pdf | ||
| Attachment_A_Abstract_Instructions_Template.docx | DOCX document |
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