HR001125S0014-Amendment-01.pdf

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CoasterChase
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HR001125S0014
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This document is Amendment 1 to a DARPA solicitation (HR001125S0014) for the CoasterChase program, which seeks innovative research proposals to develop a multimodal, ingestible sensing and stimulation platform for monitoring and modulating biomarkers of acute stress within the small intestine. The amendment primarily updates the cost proposal spreadsheet and removes language related to indirect cost rate limitations, specifically addressing a Temporary Restraining Order affecting indirect cost rate calculations.

The solicitation targets revolutionary advances in enteric neuromodulation, ingestible electronics, and stress response modulation, explicitly excluding incremental technological improvements. It is part of DARPA's Research and Technology Development program (CFDA 12.910) and welcomes proposals from various entities including universities, small businesses, and research centers. The program encourages participation from diverse sources, including U.S. and non-U.S. organizations, with a focus on fundamental research that can develop transformative defense capabilities in biomedical technologies.

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The purpose of Amendment 1 to HR001125S0014, CoasterChase, is to remove language associated with indirect cost rate limitations and update the Cost Proposal Spreadsheet. Changes bolded/highlighted/underlined below, along with an updated version of Attachment E.

Section IV Special Considerations is updated as follows:

Section IV: SPECIAL CONSIDERATIONS This announcement, stated attachments, and websites incorporated by reference constitute the entire solicitation. In the event of a discrepancy between the announcement, attachments, or websites, the announcement takes precedence.

Notwithstanding any prior Department of Defense (DoD) guidance or memoranda regarding indirect cost rate limitations, a resultant cooperative agreement award will be issued in compliance with the Temporary Restraining Order (TRO) entered on June 17, 2025, in Association of American Universities v. Department of Defense, No. 25-cv- 11740 (D. Mass.). Accordingly, the indirect cost rate applied to a resultant cooperative agreement award will reflect the institution’s current negotiated rate and does not incorporate the 15% indirect cost rate cap outlined in the Department’s memoranda dated May 14, 2025. However, if the TRO is lifted, dissolved, or otherwise modified by court order, and such order permits the implementation of the Rate Cap Policy, the policies of the memos (Rate Cap Policy Memo dated May 14, 2025 and OUSD (R&E’s) Implementation Memo dated June 12 2025) will be applicable for the entirety of the resultant cooperative agreement award.

As of the date of publication of this solicitation, all proposal submissions are anticipated to be unclassified.

All responsible sources capable of satisfying the Government's needs, including both U.S.

and non-U.S. sources, may submit a proposal that shall be considered by DARPA.

Historically Black Colleges and Universities, Small Businesses, Small Disadvantaged Businesses and Minority Institutions are encouraged to submit proposals and join others in submitting proposals; however, no portion of this announcement will be set aside for these organizations’ participation due to the impracticality of reserving discrete or severable areas of this research for exclusive competition among these entities. Non-U.S. organizations and/or individuals may participate to the extent that such participants comply with any necessary nondisclosure agreements, security regulations, export control laws, and other governing statutes applicable under the circumstances.

DARPA encourages technical solutions from all responsible sources capable of satisfying the government’s needs. To ensure fair competition across the ecosystem, DARPA prohibits contractors/performers from concurrently providing Systems Engineering Technical Assistance (SETA), Advisory and Assistance Services (A&AS), or similar support services and being a technical performer, unless the DARPA Deputy Director grants a written waiver.

DARPA extends this prohibition to University-Affiliated Research Centers (UARCs) and Federally Funded Research and Development Centers (FFRDCs) including National Labs, who as a result of their specialized expertise and areas of competencies, are able to accomplish integral tasks that cannot be met by government or contractor resources.

Therefore, these entities are highly discouraged from proposing against this solicitation as award to a UARC or FFRDC will only be made by exception. UARCs and FFRDCs interested in this solicitation, either as a prime or a subcontractor, should contact the Agency Point of Contact (POC) listed in the Overview section prior to the proposal (or abstract) due date to discuss potential participation as part of the government team or eligibility as a technical performer.

As of the date of publication of this solicitation, the Government expects that program goals as described herein may be met by proposers intending to perform fundamental research and does not anticipate applying publication restrictions of any kind to individual awards for fundamental research that may result from this solicitation. Notwithstanding this statement of expectation, the Government is not prohibited from considering and selecting research proposals that, while perhaps not qualifying as fundamental research under the foregoing definition, still meet the solicitation criteria for submissions. If proposals are selected for award that offer other than a fundamental research solution, the Government will either work with the proposer to modify the proposed statement of work to bring the research back into line with fundamental research or else the proposer will agree to restrictions in order to receive an award. For additional information on fundamental research, please visit Proposer Instructions: General Terms and Conditions.

Proposers should indicate in their proposal whether they believe the scope of the research included in their proposal is fundamental or not. While proposers should clearly explain the intended results of their research, the Government shall have sole discretion to determine whether the proposed research shall be considered fundamental and to select the award instrument type. Appropriate language will be included in resultant awards for non-fundamental research to prescribe publication requirements and other restrictions, as appropriate. This language can be found at http://www.darpa.mil/work-with-us/additional-baa.

For certain research projects, it may be possible that although the research to be performed by a potential awardee is non-fundamental research, its proposed sub-awardee’s effort may be fundamental research. It is also possible that the research performed by a potential awardee is fundamental research while its proposed sub-awardee’s effort may be non-fundamental research. In all cases, it is the potential awardee’s responsibility to explain in its proposal which proposed efforts are fundamental research and why the proposed efforts should be considered fundamental research.

DARPA’s Fundamental Research Risk-Based Security Review Process (formerly CFIP) is an adaptive risk management security program designed to help protect the critical technology and performer intellectual property associated with DARPA’s research projects by identifying the possible vectors of undue foreign influence. DARPA will create risk assessments of all proposed senior/key personnel selected for negotiation of a fundamental research grant or cooperative agreement award. The DARPA risk assessment process will be conducted separately from the DARPA scientific review process and adjudicated prior to final award. For additional information on this process, please visit Proposer Instructions:

Grants/Cooperative Agreements.

Proposals could potentially include Human Subjects Research (HSR) and/or Animal Use.

Proposers that anticipate involving human subjects or animals in the proposed research must https://www.darpa.mil/about/offices/contracts-management/proposer-general-terms/ https://www.darpa.mil/about/offices/contracts-management/proposer-general-terms/ http://www.darpa.mil/work-with-us/additional-baa http://www.darpa.mil/work-with-us/additional-baa https://www.darpa.mil/about/offices/contracts-management/grants-agreements https://www.darpa.mil/about/offices/contracts-management/grants-agreements comply with the approval procedures detailed at https://www.darpa.mil/policies/human-animal-research to include providing the information specified therein as required for proposal submission.

The APEX Accelerators program, formerly known as the Procurement Technical Assistance Program (PTAP), focuses on building strong, sustainable, and resilient U.S. supply chains by assisting a wide range of businesses that pursue and perform under contracts with the DoD, other federal agencies, state and local governments, and government prime contractors. See www.apexaccelerators.us/ for more information.

APEX Accelerators helps businesses:

o Complete registration with a wide range of databases necessary for them to participate in the government marketplace (e.g., SAM).

o Identify which agencies and offices may need their products or services and how to connect with buying agencies and offices.

o Determine whether they are ready for government opportunities and how to position themselves to succeed.

o Navigate solicitations and potential funding opportunities.

o Receive notifications of government contract opportunities on a regular basis.

o Network with buying officers, prime contractors, and other businesses.

o Resolve performance issues and prepare for audit, only if the service is needed, after receiving an award.

Project Spectrum is a nonprofit effort funded by the DoD Office of Small Business Programs to help educate the Defense Industrial Base (DIB) on compliance. Project Spectrum is vendor-neutral and available to assist businesses with their cybersecurity and compliance needs. Their mission is to improve cybersecurity readiness, resilience, and compliance for small/medium-sized businesses and the federal manufacturing supply chain. Project Spectrum events and programs will enhance awareness of cybersecurity threats within the manufacturing, research and development, and knowledge-based services sectors of the industrial base. Project Spectrum will leverage strategic partnerships within and outside of the DoD to accelerate the overall cybersecurity compliance of the DIB.

www.projectspectrum.io is a web portal that will provide resources such as individualized dashboards, a marketplace, and Pilot Program to help accelerate cybersecurity compliance.

DARPAConnect offers free resources to potential performers to help them navigate DARPA, including “Understanding DARPA Award Vehicles and Solicitations”, “Making the Most of Proposers Days”, and “Tips for DARPA Proposal Success”. Join DARPAConnect at www.DARPAConnect.us to leverage on-demand learning and networking resources.

DARPA has streamlined our Broad Agency Announcements and is interested in your feedback on this new format. Please send any comments to DARPAsolicitations@darpa.mil.

https://www.darpa.mil/policies/human-animal-research https://www.darpa.mil/policies/human-animal-research http://www.apexaccelerators.us/ http://www.projectspectrum.io/ http://www.darpaconnect.us/ mailto:DARPAsolicitations@darpa.mil

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