BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain (R01 Clinical Trial Not Allowed)

Open Posted

Opportunity number
RFA-MH-26-170
Agency
Applications due
Award size
Not on record

Opportunity facts

Funding instrument
Grant
Categories
  • Income Security and Social Services
  • Education
  • Health
Eligible applicants
  • Small Businesses
  • For Profit Organizations
  • City/Township Governments
  • State Governments
  • Special District Governments
  • 501(c)(3) Nonprofits
  • Independent School Districts
  • Public or Indian Housing Auth.
  • Tribal Governments (Federally Recognized)
  • Other
  • County Governments
  • Higher Education Inst. (Private)
  • Higher Education Inst. (Public)
  • Tribal Organizations (Not Federally Recognized)
  • Non-501(c)(3) Nonprofits
Points of contact
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institutes of Health is soliciting applications for development and validation of novel tools to probe cell-specific and circuit-specific processes in the brain, with applications due February 8, 2027. Clinical trials are not permitted under this BRAIN Initiative funding mechanism.

Eligible applicants include small businesses, for-profit organizations, nonprofits (501(c)(3) and non-501(c)(3)), state and local governments, tribal governments (federally and non-federally recognized), higher education institutions (public and private), housing authorities, and other eligible federal agencies. The opportunity also extends to Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, HBCUs, Asian American Native American Pacific Islander Serving Institutions, faith-based and community-based organizations, Tribally Controlled Colleges and Universities, and non-domestic entities.

The program encourages development of new genetic and non-genetic tools for delivering genes, proteins, and chemicals to cells of interest, and approaches targeting specific cell types and circuits in the nervous system with greater precision and sensitivity than existing methods. Tools functional across multiple species or model organisms are highly desired. Applications must include plans for validating the utility of the proposed tool or technology. Applicants are encouraged to describe approaches breaking through existing technical barriers to substantially improve current capabilities.

This opportunity is assigned to multiple NIH parent programs: Mental Health Research Grants (CFDA 93.242), Alcohol Research Programs (CFDA 93.273), Drug Use and Addiction Research Programs (CFDA 93.279), Child Health and Human Development Extramural Research (CFDA 93.865), Research Related to Deafness and Communication Disorders (CFDA 93.173), Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286), Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), Research and Training in Complementary and Integrative Health (CFDA 93.213), Aging Research (CFDA 93.866), and Vision Research (CFDA 93.867). The grant mechanism is R01; applications must use the general or research-filtered instructions provided in the application guide.

Synopsis

The purpose of this Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative is to encourage applications that will develop and validate novel tools to facilitate the detailed analysis of complex circuits and provide insights into cellular interactions that underlie brain function. The new tools and technologies should inform and/or exploit cell-type and/or circuit-level specificity. Plans for validating the utility of the tool/technology will be an essential feature of a successful application. The development of new genetic and non-genetic tools for delivering genes, proteins and chemicals to cells of interest or approaches that are expected to target specific cell types and/or circuits in the nervous system with greater precision and sensitivity than currently established methods are encouraged. Tools that can be used in a number of species/model organisms rather than those restricted to a single species are highly desired. Applications that provide approaches that break through existing technical barriers to substantially improve current capabilities are highly encouraged.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Files

File Type Posted
RFA-MH-26-170-Full-Announcement.html HTML file
PKG00288732.pdf PDF

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