Safety_Data_Sheets.pdf

Sigma - F6627

The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

Version 6.11 Revision Date 03/02/2024

Print Date 07/13/2024

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name : 5-Fluorouracil

Product Number : F6627

Brand : Sigma

CAS-No. : 51-21-8

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Synthesis of substances

Uses advised against : The product is being supplied under the TSCA R&D Exemption

(40 CFR Section 720.36). It is the recipient’s responsibility to comply with the requirements of the R&D exemption. The product may not be used for a non-exempt commercial purpose under TSCA unless appropriate consent is granted in writing by

MilliporeSigma.

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Inc.

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Acute toxicity, Oral (Category 3), H301

Carcinogenicity (Category 2), H351

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 GHS Label elements, including precautionary statements

Pictogram

Signal Word Danger

Hazard Statements

H301 Toxic if swallowed.

H351 Suspected of causing cancer.

Precautionary Statements

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P264 Wash skin thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.

Rinse mouth.

P308 + P313 IF exposed or concerned: Get medical advice/ attention.

P405 Store locked up.

P501 Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none

SECTION 3: Composition/information on ingredients

3.1 Substances

Synonyms : 5-FU

2,4-Dihydroxy-5-fluoropyrimidine

5-Fluoro-2,4(1H,3H)-pyrimidinedione

Formula : C4H3FN2O2

Molecular weight : 130.08 g/mol

CAS-No. : 51-21-8

EC-No. : 200-085-6

Component Classification Concentration

5-fluorouracil

Acute Tox. 3; Carc. 2;

H301, H351

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

Show this material safety data sheet to the doctor in attendance.

If inhaled

After inhalation: fresh air. Call in physician.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.

In case of eye contact

After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact lenses.

If swallowed

If swallowed: give water to drink (two glasses at most). Seek medical advice immediately.

In exceptional cases only, if medical care is not available within one hour, induce vomiting

(only in persons who are wide awake and fully conscious), administer activated charcoal

(20 - 40 g in a 10% slurry) and consult a doctor as quickly as possible.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section

2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Water Foam Carbon dioxide (CO2) Dry powder

Unsuitable extinguishing media

For this substance/mixture no limitations of extinguishing agents are given.

5.2 Special hazards arising from the substance or mixture

Carbon oxides

Nitrogen oxides (NOx)

Hydrogen fluoride

Combustible.

Development of hazardous combustion gases or vapours possible in the event of fire.

5.3 Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

5.4 Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact.

Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

6.2 Environmental precautions

Do not let product enter drains.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions

(see sections 7 and 10). Take up carefully. Dispose of properly. Clean up affected area.

Avoid generation of dusts.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Work under hood. Do not inhale substance/mixture.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

Tightly closed. Dry. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.

Storage class

Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

Contains no substances with occupational exposure limit values.

8.2 Exposure controls

Appropriate engineering controls

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Personal protective equipment

Eye/face protection

Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Safety glasses

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: Nitrile rubber

Minimum layer thickness: 0.11 mm

Break through time: 480 min

Material tested:KCL 741 Dermatril® L

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact

Material: Nitrile rubber

Minimum layer thickness: 0.11 mm

Break through time: 480 min

Material tested:KCL 741 Dermatril® L

Body Protection protective clothing

Respiratory protection

Recommended Filter type: Filter type P3

The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer.

These measures have to be properly documented.

required when dusts are generated.

Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: powder

b) Odor No data available

c) Odor Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/range: 282 - 286 °C (540 - 547 °F) - dec.

f) Initial boiling point and boiling range

190 - 200 °C 374 - 392 °F at 0.13 hPa

g) Flash point No data available

h) Evaporation rate No data available

i) Flammability (solid, gas)

No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapor pressure No data available

l) Vapor density No data available

m) Density No data available

Relative density No data available

n) Water solubility No data available

o) Partition coefficient:

n-octanol/water log Pow: -0.424

p) Autoignition temperature

No data available

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties none

9.2 Other safety information

SECTION 10: Stability and reactivity

10.1 Reactivity

The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.

10.2 Chemical stability

The product is chemically stable under standard ambient conditions (room temperature) .

10.3 Possibility of hazardous reactions

Violent reactions possible with:

Strong oxidizing agents

Bases

10.4 Conditions to avoid

Heat.

no information available

10.5 Incompatible materials

no information available

10.6 Hazardous decomposition products

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 230 mg/kg

Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.

Remarks: (RTECS)

Oral: absorption

Inhalation: No data available

Dermal: absorption

Skin corrosion/irritation

Remarks: slight irritation

Serious eye damage/eye irritation

No data available

Respiratory or skin sensitization

Germ cell mutagenicity

Species: Hamster

Application Route: Intraperitoneal

Remarks: Cytogenetic analysis

Species: Hamster

Application Route: Intraperitoneal

Remarks: Cytogenetic analysis

Species: Mouse

Application Route: Intravenous

Remarks: sperm

Application Route: Intravenous

Remarks: sperm

Application Route: Oral

Remarks: Other mutation test systems

Application Route: Oral

Remarks: Other mutation test systems

Carcinogenicity

Suspected of causing cancer.

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

Specific target organ toxicity - repeated exposure

Aspiration hazard

No data available

11.2 Additional Information

Nausea, Vomiting, Anorexia., Diarrhea, stomatitis, Fever, Weakness, Headache, depression, Skin irritation, Erythema, bone marrow depression, bleeding syndrome, renal impairment, death

To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.

Systemic effects:

Nausea

Vomiting

Stomach/intestinal disorders

Diarrhea

Changes in the blood count

Further data:

Therapeutically used substance.

Other dangerous properties can not be excluded.

This substance should be handled with particular care.

Stomach - Irregularities - Based on Human Evidence

SECTION 12: Ecological information

12.1 Toxicity

Toxicity to fish LC50 - Oncorhynchus mykiss (rainbow trout) - > 1,000 mg/l - 48 h

Remarks: (External MSDS)

12.2 Persistence and degradability

Biodegradability Result: 0 % - Not readily biodegradable.

(OECD Test Guideline 301C)

Result: 0 % - Not readily eliminated from water.

(OECD Test Guideline 302B)

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Endocrine disrupting properties

No data available

12.7 Other adverse effects

Discharge into the environment must be avoided.

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product

Waste material must be disposed of in accordance with the national and local regulations.

Leave chemicals in original containers. No mixing with other waste. Handle uncleaned containers like the product itself.

SECTION 14: Transport information

DOT (US)

UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solids, organic, n.o.s. (5-fluorouracil)

Reportable Quantity (RQ):

Poison Inhalation Hazard: No

IMDG

UN number: 2811 Class: 6.1 Packing group: III EMS-No: F-A, S-A

Proper shipping name: TOXIC SOLID, ORGANIC, N.O.S. (5-fluorouracil)

IATA

UN number: 2811 Class: 6.1 Packing group: III

Proper shipping name: Toxic solid, organic, n.o.s. (5-fluorouracil)

SECTION 15: Regulatory information

SARA 302 Components

5-fluorouracil

CAS-No.

51-21-8

Revision Date

2007-03-01

SARA 313 Components

The following components are subject to reporting levels established by SARA Title III, Section 313:

SARA 311/312 Hazards

Acute Health Hazard, Chronic Health Hazard

Massachusetts Right To Know Components

Pennsylvania Right To Know Components

5-fluorouracil CAS-No.

California Prop. 65 Components

, which is/are known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.5-fluorouracil

2007-09-28

SECTION 16: Other information

Further information

The information is believed to be correct but is not exhaustive and will be used solely as a guideline, which is based on current knowledge of the chemical substance or mixture and is applicable to appropriate safety precautions for the product. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its

Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.

The branding on the header and/or footer of this document may temporarily not visually match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered. For further information please contact mlsbranding@sial.com.

Version: 6.11 Revision Date: 03/02/2024 Print Date: 07/13/2024

Creation Date 12-May-2011 Revision Date 24-Dec-2021 Revision Number 3

1. Identification Product Name Formalin, Buffered, 10% (Phosphate Buffer/Certified)

Cat No. : SF100-4, SF100-20, SF100-200, XXFORMN219, NC1767270

Synonyms No information available

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300

CHEMTRECÒ, Outside the USA: 001-703-527-3887

2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements

Signal Word Danger

Hazard Statements Combustible liquid

Company Fisher Scientific Company One Reagent Lane Fair Lawn, NJ 07410 Tel: (201) 796-7100

Skin Corrosion/Irritation Category 2 Serious Eye Damage/Eye Irritation Category 1 Skin Sensitization Category 1 Germ Cell Mutagenicity Category 2 Carcinogenicity Category 1A Specific target organ toxicity (single exposure) Category 1 Target Organs - Respiratory system, Central nervous system (CNS), Optic nerve.

Flammable liquids

Page 1 / 10

Category 4

Formalin, Buffered, 10% (Phosphate Buffer/Certified) Revision Date 24-Dec-2021

Causes skin irritation May cause an allergic skin reaction Causes serious eye damage Suspected of causing genetic defects May cause cancer Causes damage to organs

Precautionary Statements Prevention Obtain special instructions before use Do not handle until all safety precautions have been read and understood Use personal protective equipment as required Wash face, hands and any exposed skin thoroughly after handling Contaminated work clothing should not be allowed out of the workplace Wear protective gloves Do not breathe dust/fume/gas/mist/vapors/spray Do not eat, drink or smoke when using this product Keep away from heat/sparks/open flames/hot surfaces. - No smoking

Response IF exposed: Call a POISON CENTER or doctor/physician

Skin IF ON SKIN: Wash with plenty of soap and water Take off contaminated clothing and wash before reuse If skin irritation or rash occurs: Get medical advice/attention

Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing Immediately call a POISON CENTER or doctor/physician

Fire In case of fire: Use CO2, dry chemical, or foam for extinction

Storage Store locked up Store in a well-ventilated place. Keep cool

Disposal Dispose of contents/container to an approved waste disposal plant

Hazards not otherwise classified (HNOC) None identified WARNING. Reproductive Harm - https://www.p65warnings.ca.gov/.

3. Composition/Information on Ingredients

Component CAS No Weight % Water 7732-18-5 92-94

Formaldehyde 50-00-0 4.0

Methyl alcohol 67-56-1 1.0 - 2.0

Sodium phosphate dibasic 7558-79-4 0.7

Phosphoric acid, monosodium salt, monohydrate 10049-21-5 0.4

4. First-aid measures

General Advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is

Page 2 / 10 required.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.

Immediate medical attention is required.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Get medical attention.

Inhalation Remove to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Immediate medical attention is required.

Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and effects

May cause allergic skin reaction. Difficulty in breathing. . Causes eye burns. Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting

Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may be used to cool closed containers.

Unsuitable Extinguishing Media No information available

Flash Point 81 °C / 177.8 °F

Method - No information available

Autoignition Temperature No information available

Explosion Limits Upper No data available

Lower No data available

Sensitivity to Mechanical Impact No information available

Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical Combustible material. Risk of ignition. Containers may explode when heated. Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition.

Hazardous Combustion Products Carbon monoxide (CO). Carbon dioxide (CO2).

Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

NFPA

6. Accidental release measures Personal Precautions Use personal protective equipment as required. Evacuate personnel to safe areas. Remove all sources of ignition. Take precautionary measures against static discharges. Ensure adequate ventilation. Do not get in eyes, on skin, or on clothing.

Environmental Precautions Should not be released into the environment. See Section 12 for additional Ecological Information.

Health

Flammability

Instability

Physical hazards N/A

Page 3 / 10

Methods for Containment and Clean Up

Remove all sources of ignition. Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

7. Handling and storage Handling Use only under a chemical fume hood. Wear personal protective equipment/face protection.

Do not get in eyes, on skin, or on clothing. Do not breathe mist/vapors/spray. Do not ingest.

If swallowed then seek immediate medical assistance. Keep away from open flames, hot surfaces and sources of ignition.

Storage. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat, sparks and flame.

8. Exposure controls / personal protection Exposure Guidelines

9. Physical and chemical properties Physical State Liquid

Appearance Clear

Odor pungent

Odor Threshold No information available pH 6.9 - 7.1

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA) Formaldehyde TWA: 0.1 ppm

STEL: 0.3 ppm (Vacated) TWA: 3 ppm

(Vacated) STEL: 10 ppm (Vacated) Ceiling: 5 ppm

TWA: 0.75 ppm STEL: 2 ppm

IDLH: 20 ppm TWA: 0.016 ppm Ceiling: 0.1 ppm

Ceiling: 0.3 ppm

Methyl alcohol TWA: 200 ppm STEL: 250 ppm

Skin

(Vacated) TWA: 200 ppm (Vacated) TWA: 260 mg/m3

(Vacated) STEL: 250 ppm (Vacated) STEL: 325 mg/m3

Skin TWA: 200 ppm

TWA: 260 mg/m3

IDLH: 6000 ppm TWA: 200 ppm

TWA: 260 mg/m3

STEL: 250 ppm STEL: 325 mg/m3

TWA: 200 ppm STEL: 250 ppm

Legend

ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and Health Administration NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Use only under a chemical fume hood. Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard

EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures

Page 4 / 10

Handle in accordance with good industrial hygiene and safety practice.

Melting Point/Range 0 °C / 32 °F

Boiling Point/Range 93.9 - 100 °C / 201 - 212 °F

Flash Point 81 °C / 177.8 °F

Evaporation Rate > 1.0

Flammability (solid,gas) Not applicable

Flammability or explosive limits Upper No data available

Lower No data available

Vapor Pressure No information available

Vapor Density 1.0

Specific Gravity 1.10

Solubility miscible

Partition coefficient; n-octanol/water No data available

Autoignition Temperature No information available

Decomposition Temperature No information available

Viscosity No information available

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products. Excess heat. Keep away from open flames, hot surfaces and sources of ignition.

Incompatible Materials Strong oxidizing agents

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2)

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information Acute Toxicity

Product Information Oral LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.

Dermal LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.

Vapor LC50 Based on ATE data, the classification criteria are not met. ATE > 20 mg/l.

Component Information Component LD50 Oral LD50 Dermal LC50 Inhalation

Water - - -

Formaldehyde 500 mg/kg (Rat) LD50 = 270 mg/kg (Rabbit) 0.578 mg/L (Rat) 4 h

Methyl alcohol LD50 = 1187 – 2769 mg/kg (Rat) LD50 = 17100 mg/kg ( Rabbit ) LC50 = 128.2 mg/L ( Rat ) 4 h

Sodium phosphate dibasic LD50 = 17 g/kg ( Rat ) Not listed Not listed

Toxicologically Synergistic Products

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Severe eye irritant; Irritating to skin

Sensitization May cause sensitization by skin contact

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Page 5 / 10

Water 7732-18-5 Not listed Not listed Not listed Not listed Not listed

Formaldehyde 50-00-0 Group 1 Known A1 X A2

Methyl alcohol 67-56-1 Not listed Not listed Not listed Not listed Not listed

Sodium phosphate dibasic

7558-79-4 Not listed Not listed Not listed Not listed Not listed

Phosphoric acid, monosodium salt, monohydrate

10049-21-5 Not listed Not listed Not listed Not listed Not listed

IARC (International Agency for Research on Cancer) IARC (International Agency for Research on Cancer) Group 1 - Carcinogenic to Humans Group 2A - Probably Carcinogenic to Humans Group 2B - Possibly Carcinogenic to Humans

NTP: (National Toxicity Program) NTP: (National Toxicity Program) Known - Known Carcinogen Reasonably Anticipated - Reasonably Anticipated to be a Human Carcinogen

ACGIH: (American Conference of Governmental Industrial Hygienists)

A1 - Known Human Carcinogen A2 - Suspected Human Carcinogen A3 - Animal Carcinogen ACGIH: (American Conference of Governmental Industrial Hygienists)

Mexico - Occupational Exposure Limits - Carcinogens Mexico - Occupational Exposure Limits - Carcinogens A1 - Confirmed Human Carcinogen A2 - Suspected Human Carcinogen A3 - Confirmed Animal Carcinogen A4 - Not Classifiable as a Human Carcinogen A5 - Not Suspected as a Human Carcinogen

Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure Respiratory system Central nervous system (CNS) Optic nerve

STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and delayed

Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing:

Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information Ecotoxicity The product contains following substances which are hazardous for the environment.

Component Freshwater Algae Freshwater Fish Microtox Water Flea Formaldehyde Not listed Leuciscus idus: LC50 = 15 mg/L 96h Not listed EC50 = 20 mg/L 96h

EC50 = 2 mg/L 48h

Methyl alcohol Not listed Pimephales promelas: LC50 > 10000 mg/L 96h

EC50 = 39000 mg/L 25 min EC50 = 40000 mg/L 15 min EC50 = 43000 mg/L 5 min

EC50 > 10000 mg/L 24h

Persistence and Degradability Miscible with water Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility . Will likely be mobile in the environment due to its water solubility.

Page 6 / 10

Component log Pow Formaldehyde -0.35

Methyl alcohol -0.74

13. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

Component RCRA - U Series Wastes RCRA - P Series Wastes Formaldehyde - 50-00-0 U122 -

Methyl alcohol - 67-56-1 U154 -

14. Transport information

DOT COMBUSTIBLE LIQUID, NOT REGULATED FOR TRANSPORT IN THIS QUANTITY

According to 49 CFR §173.150(f)(1), this material should reclassified as NA1993, Combustible Liquid, NOS if it is shipped in bulk.

UN-No NA1993

Proper Shipping Name Combustible liquid, n.o.s.

Packing Group III

TDG Not regulated

IATA Not regulated

IMDG/IMO Not regulated

15. Regulatory information

United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - Active-Inactive

TSCA - EPA Regulatory Flags

Water 7732-18-5 X ACTIVE -

Formaldehyde 50-00-0 X ACTIVE -

Methyl alcohol 67-56-1 X ACTIVE -

Sodium phosphate dibasic 7558-79-4 X ACTIVE -

Phosphoric acid, monosodium salt, monohydrate

10049-21-5 - - -

Legend:

TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed

TSCA 12(b) - Notices of Export Not applicable

International Inventories Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea

(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL Water 7732-18-5 X - 231-791-2 X X X X KE-35400

Formaldehyde 50-00-0 X - 200-001-8 X X X X X KE-17074

Methyl alcohol 67-56-1 X - 200-659-6 X X X X X KE-23193

Sodium phosphate dibasic 7558-79-4 X - 231-448-7 X X X X X KE-12344

Phosphoric acid, monosodium salt, monohydrate

10049-21-5 - - - X X X X -

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

Page 7 / 10

U.S. Federal Regulations

SARA 313

Component CAS No Weight % SARA 313 - Threshold

Values % Formaldehyde 50-00-0 4.0 0.1

Methyl alcohol 67-56-1 1.0 - 2.0 1.0

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Component CWA - Hazardous

Substances CWA - Reportable

Quantities CWA - Toxic Pollutants CWA - Priority Pollutants

Formaldehyde X 100 lb - -

Sodium phosphate dibasic X 5000 lb - -

Clean Air Act Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors

Formaldehyde X -

Methyl alcohol X -

OSHA - Occupational Safety and Health Administration

Component Specifically Regulated Chemicals Highly Hazardous Chemicals

Formaldehyde 2 ppm STEL

0.5 ppm Action Level

0.75 ppm TWA

TQ: 1000 lb

CERCLA This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302)

Component Hazardous Substances RQs CERCLA EHS RQs

Formaldehyde 100 lb 100 lb

Methyl alcohol 5000 lb -

Sodium phosphate dibasic 5000 lb -

California Proposition 65 This product contains the following Proposition 65 chemicals.

Component CAS No California Prop. 65 Prop 65 NSRL Category

Formaldehyde 50-00-0 Carc. (Gaseous only) 40 µg/day Carcinogen

Methyl alcohol 67-56-1 Developmental - Developmental

U.S. State Right-to-Know Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Water - - X - -

Formaldehyde X X X X X

Methyl alcohol X X X X X

Sodium phosphate dibasic

X X X - -

U.S. Department of Transportation Reportable Quantity (RQ): Y DOT Marine Pollutant N DOT Severe Marine Pollutant N

U.S. Department of Homeland Security

This product contains the following DHS chemicals:

Legend - STQs = Screening Threshold Quantities, APA = A placarded amount

Page 8 / 10

Component DHS Chemical Facility Anti-Terrorism Standard Formaldehyde Release STQs - 15000lb (solution)

Other International Regulations

Mexico - Grade Moderate risk, Grade 2

Authorisation/Restrictions according to EU REACH

Component REACH (1907/2006) - Annex XIV - Substances Subject to

Authorization

REACH (1907/2006) - Annex XVII - Restrictions on Certain Dangerous

Substances

REACH Regulation (EC 1907/2006) article 59 - Candidate List of Substances of Very High

Concern (SVHC) Formaldehyde - Use restricted. See item 72.

(see link for restriction details) Use restricted. See item 28.

(see link for restriction details) Use restricted. See item 75.

(see link for restriction details)

Methyl alcohol - Use restricted. See item 69.

(see link for restriction details) https://echa.europa.eu/substances-restricted-under-reach

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Pollutant

Ozone Depletion Potential

Restriction of Hazardous

Substances (RoHS) Water 7732-18-5 Listed Not applicable Not applicable Not applicable

Formaldehyde 50-00-0 Listed Not applicable Not applicable Not applicable

Methyl alcohol 67-56-1 Listed Not applicable Not applicable Not applicable

Sodium phosphate dibasic 7558-79-4 Listed Not applicable Not applicable Not applicable

Phosphoric acid, monosodium salt, monohydrate

10049-21-5 Not applicable Not applicable Not applicable Not applicable

Component CAS No Seveso III Directive

(2012/18/EC) -

Qualifying Quantities for Major Accident

Notification

Seveso III Directive

(2012/18/EC) -

Qualifying Quantities for Safety Report

Requirements

Rotterdam Convention (PIC)

Basel Convention (Hazardous Waste)

Water 7732-18-5 Not applicable Not applicable Not applicable Not applicable

Formaldehyde 50-00-0 5 tonne 50 tonne Not applicable Not applicable

Methyl alcohol 67-56-1 500 tonne 5000 tonne Not applicable Not applicable

Sodium phosphate dibasic 7558-79-4 Not applicable Not applicable Not applicable Not applicable

Phosphoric acid, monosodium salt, monohydrate

10049-21-5 Not applicable Not applicable Not applicable Not applicable

16. Other information Prepared By Regulatory Affairs

Thermo Fisher Scientific Email: EMSDS.RA@thermofisher.com

Creation Date 12-May-2011

Revision Date 24-Dec-2021

Print Date 24-Dec-2021

Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard replacing the current legislation under 29 CFR 1910.1200 to align with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

Page 9 / 10

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

End of SDS

Page 10 / 10

454628 / B / 2022–May–3

SECTION 1: Identification

The specification describes the technical parameters for the battery.

The Transponder battery is a custom made lithium battery.

Battery name Part number

L24 (98) 290-219492

L10/36 (18/30) 290-101665

L10/50 (12/42) 290-089592

L10/36 (15/40) 290-103179

• Manufacturer: Kongsberg Maritime AS

• Address: Strandpromenaden 50, 3190 Horten, Norway

• Telephone: +47 33 03 24 07 (24 h)

• Telefax: +47 33 04 29 87

• Email address: km.support.hpr@kongsberg.com

• Website : https://www.kongsberg.com/maritime

Note The battery is provided as a solid and sealed unit. It cannot be opened to reveal individual cells.

SECTION 2: Hazards identification

The battery is not labelled with a hazmat label. It is not classified as dangerous or hazardous when undamaged and used as intended, and as such it is exempted from GHS (Globally Harmonized System of Classification and Labelling of Chemicals) classification and labelling.

Do not open, disassemble, crush or burn the battery. The battery contains dangerous ingredients. Exposure to the ingredients contained within the battery cells could be harmful. The battery cells include a barrier, preventing exposure to the user and environment. The battery cells are not classified as hazardous according to Regulation (EC) No. 1272/2008.

The chemicals in the battery cells are contained in a sealed enclosure. Risk of exposure occurs only if the cell is mechanically, thermally or electrically abused to the point of compromising the enclosure. If this occurs, exposure to the electrolyte solution contained within can occur by inhalation, ingestion, eye contact and skin contact. The electrolyte solution can be corrosive and may cause irritation and burns.

Other hazards

• External fire: Internal pressure and thermal runaway may be the consequences if the cells inside the battery are exposed to temperatures above 85 °C.

• Internal short circuit: Internal short circuit in a cell. Destruction of the separator can cause a short circuit between the anode and cathode.

Thermal runaway and fire is possible.

• Water ingress: Internal pressure, thermal runway and chemical reactions may be the consequence.

The transponder might be fitted with a pressure relief valve at the bottom of the unit. The relief valve prevents overpressure. Noxious gases and ingredients will then leak out of the transponder until the chemical reactions have stopped. Products generated by the chemical reactions during an emergency may however clog this pressure release valve.

SECTION 3: Composition

The battery is a solid, manufactured article.

A battery pack consists of several individual cells that are electrically connected, both in series and parallel.

The battery packs have different number of cells and power capacity. All transponder batteries include protection against short circuits (circuit breakers) and reverse current (diodes).

Transponder battery

Battery safety datasheet mailto:km.support.hpr@kongsberg.com https://www.kongsberg.com/maritime

The lithium metal cells have the following chemical formula:

Lithium thionyl chloride — Li/SOCl2

• Negative electrode: Lithium

• Positive electrode: Carbon

• Electrolyte: A solution of lithium tetrachloroaluminate (LiAlCl4) in thionyl chloride

Battery identification:

Battery name Battery weight Lithium weight Part number

L24 (98) 11.0 kg 490 g 290-219492

L10/36 (18/30) 5.6 kg 240 g 290-101665

L10/50 (12/42) 6.5 kg 228 g 290-089592

L10/36 (15/40) 6.6 kg 235 g 290-103179

In case of hazardous events, the noxious gases are:

• Thionyl chloride (SOCl2)

• Sulphur dioxide (SO2)

• Hydrogen sulphide (H2S)

• Hydrogen chloride (HCl)

• Chlorine (Cl2)

For additional information about the cells inside the sealed battery pack, see the safety data sheet provided by the cell manufacturers.

• Manufacturer: Saft

• Cell type: LSH 20

• Manufacturer’s website: https://www.saftbatteries.com/

• Manufacturer: Tadiran

• Cell type: SL-2780

• Manufacturer’s website: https://tadiranbatteries.de/eng/

SECTION 4: First aid measures

The battery will release toxic fumes if burned or exposed to fire.

If subjected to gas from a burning battery, remove the source of contamination or move yourself and any victims to fresh air. Seek medical advice.

• Inhalation: The chemicals are lung irritant. Avoid inhaling any vented gases. Remove the victim and yourself from exposure. Rest and keep warm. If breathing is difficult, seek emergency medical attention.

• Skin contact: The chemicals are skin irritant. Rinse immediately with a lot of water and soap for at least 15 minutes. Wipe immediately away excess material with waterless hand cleaner. Remove contaminated clothing and wash it thoroughly before reuse.

• Eye contact: The chemicals are eye irritant. Flush immediately with a lot of clear tepid water for at least 15 minutes.

• Ingestion: Exposure to the chemicals may cause tissue damage to throat and gastro/respiratory tract if swallowed. If ingested, rinse mouth and surrounding area with tepid water. Dilute by drinking plenty of water. Seek medical advice.

SECTION 5: Firefighting measures

The transponder is designed to withstand damage to the internal battery pack. Non-flammable materials are used. In case of fire, move the battery away from the fire area if you can do it without compromising your own safety. Extreme mechanical abuse to the battery may result in a ruptured seal and exposure.

1 If possible, move the battery and/or the transponder away from the fire.

2 Cool it down using lots of cold water.

a Immerse the battery and/or the transponder in the sea for minimum 24 hours.

b If this method is impossible, it can be cooled down with a fire hose.

Cooling down the battery with a large amount of cold water is the only way to reduce or stop the internal chemical reactions, or to limit the fire/explosions to as few battery cells as possible. The chemical reactions/fire will continue without additional supply of oxygen, so an extinguisher such as Lith-X will not work properly.

454628 / B / 2022–May–3 https://www.saftbatteries.com/ https://tadiranbatteries.de/eng/

Applying water directly onto a battery may develop hydrogen gas, due to the possible electrolysis if the battery terminals are exposed to water. Mixed with air, this gas is very inflammable/explosive. However, if the water cooling takes place on deck or in a storage room with good ventilation, there will never be enough hydrogen gas to exceed the lower explosive limit of hydrogen in air (about 4 %).

Note In case of an external fire, always remove transponder units and lithium batteries.

SECTION 6: Accidental release measures

During normal operation, accidental release measures are not applicable. Extreme mechanical abuse to the battery may result in a ruptured seal and exposure.

As an immediate precautionary measure, isolate the spill or leak area at least 25 metres (75 feet) in all directions. Keep unauthorized personnel away.

Stay upwind, and keep out of low areas. Ventilate closed areas before entering. Wear adequate personal protective equipment.

Prevent material from contaminating soil and from entering sewers or waterways. Stop the leak if safe to do so. Contain the spilled liquid with dry sand or earth. Clean up the spills immediately.

Absorb spilled material with an inert absorbent (dry sand or earth). Scoop contaminated absorbent into an acceptable waste container. Collect all contaminated absorbent and dispose of it according to relevant regulations. Scrub the area with detergent and water; collect all contaminated water for proper disposal.

SECTION 7: Handling and storage

Do not open, disassemble, crush or burn the battery.

1 Do not expose the battery to water, sea water or other high-conductivity liquids.

2 Avoid mechanical or electrical abuse.

3 Do not expose the battery to temperatures outside the range of -40 °C to +80 °C.

4 Store in a dry location.

Recommended relative air humidity is 40 to 70 %. To minimize any adverse affects on the battery performance it is recommended that it is kept at room temperature (25 °C ± 5 °C). Higher temperatures can result in shortened life.

5 Do not store the battery in direct sunlight.

6 Keep the battery out of reach of children.

The storage room must be properly ventilated. It must be provided with sturdy racks with dedicated cradles for the batteries, and allow for easy removal of batteries in case of fire. The room must be designated and clearly identified as a storage area, and entrance should be restricted. The room must not be used as a general rest or work area.

Note The storage room must have a sprinkler system or a fire station. A suitable fire hose (with water) must be placed outside or in the proximity of the room.

SECTION 8: Exposure control and personal protection

Airborne exposures to hazardous substances are not expected when the battery is undamaged and used as intended. Personal protective equipment (PPE) is not required when the battery is undamaged and used as intended. Don personal protective equipment if the battery is damaged and you are at risk for exposure to the chemicals inside.

In the event of fire or physical damage to the battery, follow the mandatory rules for personal protection.

• Fire or explosion: Don a self-contained breathing apparatus (SCBA).

• Exposure to noxious gas: Use a full-face mask with minimum BE filter and protective equipment of rubber or plastic. (B refers to protection against inorganic gases and E refers to protection against sulphur dioxide.)

SECTION 9: Physical and chemical properties

The battery is solid with a firm and hard surface. There is no risk for exposure to the chemicals inside an undamaged battery during normal operation and transportation.

The battery pack is a solid and sealed unit. The battery pack cannot be opened to reveal the individual cells.

For additional information about the cells inside the sealed battery pack, see the safety data sheet provided by the cell manufacturer.

454628 / B / 2022–May–3

Cell manufacturer

• Manufacturer: Saft

• Manufacturer’s website: https://www.saftbatteries.com/

• Manufacturer: Tadiran

• Manufacturer’s website: https://tadiranbatteries.de/eng/

SECTION 10: Stability and reactivity

The battery is stable. No specific handling requirements apply.

In normal use, the battery pack is placed inside the sealed transponder.

In normal use, the battery pack is placed inside the sealed SCU.

Water ingress into the transponder can cause dangerous situations.

Water ingress into the SCU can cause dangerous situations.

Short-circuiting, overheating, mechanical damage and exposure to water can start chemical reactions and cause high currents inside the lithium battery. This can generate noxious gases and/or cause danger of explosion. The chemical reactions will continue without additional supply of oxygen, as the battery cells contain the necessary ingredients for maintaining the chemical reactions.

1 Do not open, disassemble, crush or burn the battery.

2 Do not expose the battery to water, sea water or other high-conductivity liquids.

3 Avoid mechanical or electrical abuse.

4 Do not expose the battery to temperatures outside the range of -40 °C to +80 °C.

5 Store in a dry location.

Recommended relative air humidity is 40 to 70 %. To minimize any adverse affects on the battery performance it is recommended that it is kept at room temperature (25 °C ± 5 °C). Higher temperatures can result in shortened life.

6 Do not store the battery in direct sunlight.

7 Keep the battery out of reach of children.

SECTION 11: Toxicological information

Acute oral, dermal and inhalation toxicity data are not available for this battery.

Risk of irritation occurs only if the battery is abused to the point of breaking the container and opening it to reveal the individual cells. If this occurs, irritation to the skin, eyes and respiratory tract may occur.

SECTION 12: Ecological information

Provided that the battery pack is disposed of according to local regulations and/or law, it will not have any environmental impact.

SECTION 13: Disposal considerations

Dispose of the batteries in accordance with local, state and federal laws and regulations for batteries.

A lithium thionyl chloride battery does not contain any heavy metals, and is therefore not regarded as special waste (contains only biodegradable parts).

A used lithium battery can contain a significant amount of residual energy. It is the danger of explosion that presents a problem when disposing a battery. Used batteries must therefore be handled with the same care as new ones.

Note For safe disposal, contact the nearest local company that has been approved to collect and dispose of lithium batteries.

SECTION 14: Transport information

Transportation must be performed in accordance with rules and regulations stated for transportation of dangerous goods in the applicable countries.

Certification: UN 38.3

Transport identification codes:

• Aircraft: IATA DGR

• Sea transport: IMDG

454628 / B / 2022–May–3 https://www.saftbatteries.com/

• Railway: RID

• Road transport: ADR

Original shipping boxes must be used for all transport.

Air transport of all units with new lithium batteries, and new separate lithium batteries, is only permitted on board cargo aircraft. The goods must be clearly labelled: CARGO AIRCRAFT ONLY.

The transponders with batteries or batteries must be shipped in accordance with the prevailing national regulations.

• Separate lithium batteries

– UN 3090 PI 968, Section IA

• Lithium batteries contained in equipment

– UN 3091 PI 970, Section I

Note During transport a lithium battery must always be disconnected from the electronics.

SECTION 15: Regulatory information

Not applicable.

SECTION 16: Other information

The battery manufacturer’s safety datasheet is available on their website.

Saft: http://www.saftbatteries.com/

Tadiran: https://tadiranbatteries.de/eng/

Always read the emergency procedures before handling lithium batteries.

454628 / B / 2022–May–3 http://www.saftbatteries.com/

Sigma-Aldrich- 288306 Page 1 of 19

The life science business of Merck operates as MilliporeSigma in the US and Canada

Version 6.12

Revision Date 01/02/2025 Print Date 01/03/2025

SECTION 1. IDENTIFICATION

1.1 Product identifiers

Product name : Chloroform

Product Number : 288306

Brand : Sigma-Aldrich

Index-No. : 602-006-00-4

CAS-No. : 67-66-3

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Synthesis of substances

Uses advised against : The product is being supplied under the TSCA R&D Exemption

(40 CFR Section 720.36). It is the recipient’s responsibility to comply with the requirements of the R&D exemption. The prod-uct may not be used for a non-exempt commercial purpose un-der TSCA unless appropriate consent is granted in writing by

MilliporeSigma.

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Inc.

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2. HAZARDS IDENTIFICATION

GHS classification in accordance with the OSHA Hazard Communication

Standard (29 CFR 1910.1200)

Acute toxicity (Oral)

: Category 4

Sigma-Aldrich- 288306 Page 2 of 19

Acute toxicity

(Inhalation)

: Category 3

Skin irritation

: Category 2

Eye irritation

: Category 2A

Carcinogenicity

Reproductive toxicity

Spec…