Att10AdditionalBusProposalInstruc.pdf

Attachment 10 – Additional Business Proposal Instructions

ADDITIONAL BUSINESS PROPOSAL INSTRUCTIONS

NCI GENOMIC CHARACTERIZATION CENTERS

Note to Offerors: Proposals for Sample Task Orders will not result in actual awards.

I. Fixed Price

A budget is not required for the Base Indefinite Delivery Indefinite Quantity (IDIQ) Statement of Work (SOW). However, offerors shall prepare a separate budget for each sample task order SOW the offeror is proposing. Offerors do not have to propose on all task orders but may. Task Orders under this IDIQ will be funded using a fixed unit price mechanism on a per-sample basis. Therefore, the offeror shall provide a detailed proposal of their fully loaded (including all direct costs, indirect costs, and any applicable fixed-fee) per-unit prices using the applicable pricing table(s) below. The per-unit fixed price shall meet the required turnaround timeline specified in each applicable Sample Task Order Statement of Work. The per-unit price shall provide characterization that meets all specific quality metrics in the task descriptions below. The per-unit price shall apply to any volume capacity, except where noted. Offerors shall indicate if per-unit prices are planned to increase or decrease throughout the performance period.

II. Budget Narrative

In addition to completing the applicable pricing table(s), offerors shall submit a Budget Narrative addressing the areas below:

A. Production Capacity

CCG does not guarantee a minimum number of cases to be awarded in any task order; the case quantities to be priced in the task orders are for evaluation purposes only. Offerors must be able to process at least the Minimum Case Capacity listed in the Pricing Table sections below, where applicable. Offerors shall indicate “N/A” for any protocols they are not proposing.

B. Failure Rate

CCG will pay one fixed unit price per sample/case, as applicable. CCG will not pay multiple times for the same protocol to be run on the same case (for example, a failed case needing to be re-sequenced).

III. Pricing Tables

A. Pool 1: GCC Sample Task Order - DNA Sequencing

The table below lists the protocols for which offerors shall provide information, if applicable. The below per sample unit prices shall include all allowable and allocable costs the offeror shall incur in performing the work. Offerors are to submit firm fixed price estimates, per the listed sequencing types below. The number of samples provided below are for price evaluation purposes and will not result in actual task order awards.

Sequencing Protocol Number of

Samples Fixed Unit Price per sample Total Cost

Whole Genome Sequencing (WGS), 15X coverage, normal or tumor

100 =

Whole Genome Sequencing (WGS), 30X coverage, normal or tumor

100 =

Whole Genome Sequencing (WGS), 80X coverage, normal or tumor

B. Pool 2: GCC Sample Task Order - RNA Sequencing

The table below lists the protocols for which offerors shall provide information, if applicable. The below per sample unit prices shall include all allowable and allocable costs the offeror shall incur in performing the work. Offerors are to submit firm fixed price estimates, per the listed sequencing types below. The number of samples provided below are

Fixed Unit Price per sample Total Cost

Total RNA sequencing 100 = miRNA sequencing 100 =

C. Pool 3. GCC Sample Task Order - Epigenome Characterization

The table below lists the protocols for which offerors shall provide information, if applicable. The below per sample unit prices shall include all allowable and allocable costs the offeror shall incur in performing the work. Offerors are to submit firm fixed price estimates, per the listed sequencing types below. The number of samples provided below are

Fixed Unit Price per sample Total Cost

Methylation EPIC array v2.0 100 = Methylation sequencing 100 = ATAC sequencing 100 =

D. Pool 4: GCC Sample Task Order - Single-Cell/Spatial Characterization

The table below lists the protocols for which offerors shall provide information, if applicable. The below per sample unit prices shall include all allowable and allocable costs the offeror shall incur in performing the work. Offerors are to submit firm fixed price estimates, per the listed sequencing types below. The number of samples provided below are

Sample Fixed Unit

Price Total Cost

Single Cell RNA sequencing 100 = Single Cell ATAC sequencing 100 = High-resolution Spatial transcriptome analysis of FFPE and Fresh Frozen tissues

100 =

In-Situ spatial gene expression with cellular/subcellular resolution

IV. Contract Orientation Kickoff Meeting Offerors shall treat the Kickoff Meeting as an actual task order and provide a fully loaded labor-hours budget by labor category for a one-hour conference call for all staff working on the CCG program and up to two hours of preparation time for each resource. Preparation time will be used to assist in scheduling the meeting, securing a meeting venue for the offeror’s staff, and compiling questions or other topics for discussion with CCG. Discussion may include contract administration and information and clarification on the IDIQ contract mechanism. As the Kickoff Task Order will be separate from any task order for genomic characterization, specific technical project details will not be discussed. The Kickoff Task Order will satisfy the minimum guarantee on the contract. Please reference Attachment 9 “SOW for Contract Orientation and Kick-off meeting” for additional details.

IMPORTANT NOTE: Please be sure to complete Attachment 18 – Breakdown of Proposed Estimated Costs Excel Spreadsheet (per proposed Pool(s) to include the information discussed in the tables above (fixed price per sequencing type).