Isopropanol SDS.pdf

SAFETY DATA SHEET

Creation Date 28-Jan-2010 Revision Date 13-Oct-2023 Revision Number 9

1. Identification Product Name Isopropyl alcohol, 70% in water

Cat No. : A459-1; A459-20; A459-4; A459-500; XXA459N119; A459-200;

XXA45910LI; NC1883130; NC1321602; NC2070308; NC2401443

Synonyms IPA; Isopropanol (70% aqueous solution)

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements

Signal Word Danger

Hazard Statements Highly flammable liquid and vapor Causes serious eye irritation May cause drowsiness or dizziness

Company Fisher Scientific Company One Reagent Lane Fair Lawn, NJ 07410 Tel: (201) 796-7100

Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, Outside the USA: 001-703-527-3887

Serious Eye Damage/Eye Irritation Category 2 Specific target organ toxicity (single exposure) Category 3 Target Organs - Central nervous system (CNS).

Flammable liquids Category 2

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Isopropyl alcohol, 70% in water Revision Date 13-Oct-2023

Precautionary Statements Prevention Wash face, hands and any exposed skin thoroughly after handling Avoid breathing dust/fume/gas/mist/vapors/spray Use only outdoors or in a well-ventilated area Keep away from heat/sparks/open flames/hot surfaces. - No smoking Keep container tightly closed Ground/bond container and receiving equipment Use explosion-proof electrical/ventilating/lighting equipment Use only non-sparking tools Take precautionary measures against static discharge Wear protective gloves/protective clothing/eye protection/face protection Keep cool Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Call a POISON CENTER or doctor/physician if you feel unwell Skin IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing If eye irritation persists: Get medical advice/attention Fire In case of fire: Use CO2, dry chemical, or foam for extinction Storage Store in a well-ventilated place. Keep container tightly closed Store locked up Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) None identified

3. Composition/Information on Ingredients

Component CAS No Weight % Isopropyl alcohol 67-63-0 64.7

Water 7732-18-5 35.3

4. First-aid measures

General Advice If symptoms persist, call a physician.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get medical attention.

Skin Contact Wash off immediately with soap and plenty of water. If skin irritation persists, call a physician.

Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get medical attention if symptoms occur.

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Ingestion Clean mouth with water and drink afterwards plenty of water.

Most important symptoms and effects

Difficulty in breathing. Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, tiredness, nausea and vomiting

Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media CO 2, dry chemical, dry sand, alcohol-resistant foam. Water mist may be used to cool closed containers.

Unsuitable Extinguishing Media Water may be ineffective

Flash Point 18 °C / 64.4 °F

Method - No information available

Autoignition Temperature 399 °C / 750.2 °F

Explosion Limits Upper 12.7 vol % Lower 2.0 vol % Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical Flammable. Risk of ignition. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.

Containers may explode when heated. Vapors may form explosive mixtures with air.

Hazardous Combustion Products Carbon monoxide (CO). Carbon dioxide (CO2). peroxides.

Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.

NFPA

6. Accidental release measures Personal Precautions Use personal protective equipment as required. Ensure adequate ventilation. Remove all sources of ignition. Take precautionary measures against static discharges.

Environmental Precautions Should not be released into the environment. See Section 12 for additional Ecological

Information.

Methods for Containment and Clean Up

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.

7. Handling and storage Handling Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on clothing. Ensure adequate ventilation. Avoid ingestion and inhalation. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. To avoid ignition of vapors by static electricity discharge, all metal parts of the equipment must be grounded.

Take precautionary measures against static discharges.

Storage. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat, sparks and flame. Flammables area. Incompatible Materials. Strong oxidizing

Health

Flammability

Instability

Physical hazards N/A

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8. Exposure controls / personal protection Exposure Guidelines

9. Physical and chemical properties Physical State Liquid Appearance Colorless Odor Alcohol-like Odor Threshold No information available pH No information available Melting Point/Range -88 °C / -126.4 °F Boiling Point/Range 82 °C / 179.6 °F Flash Point 18 °C / 64.4 °F Evaporation Rate 1.7 (Butyl Acetate = 1.0) Flammability (solid,gas) Not applicable Flammability or explosive limits

Upper 12.7 vol % Lower 2.0 vol %

Vapor Pressure 20 mmHg @ 332°C Vapor Density 2.1 (Air = 1.0) Specific Gravity 0.7850 Solubility Miscible with water Partition coefficient; n-octanol/water No data available

Component ACGIH TLV OSHA PEL NIOSH Mexico OEL (TWA) Isopropyl alcohol TWA: 200 ppm

STEL: 400 ppm (Vacated) TWA: 400 ppm

(Vacated) TWA: 980 mg/m3

(Vacated) STEL: 500 ppm (Vacated) STEL: 1225 mg/m3

TWA: 400 ppm TWA: 980 mg/m3

IDLH: 2000 ppm TWA: 400 ppm

TWA: 980 mg/m3

STEL: 500 ppm STEL: 1225 mg/m3

TWA: 200 ppm STEL: 400 ppm

Legend

ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and Health Administration NIOSH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Ensure adequate ventilation, especially in confined areas. Use explosion-proof electrical/ventilating/lighting equipment. Ensure that eyewash stations and safety showers are close to the workstation location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard

EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Recommended Filter type: Organic gases and vapours filter. Type A. Brown. conforming to EN14387.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

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Autoignition Temperature 399 °C / 750.2 °F Decomposition Temperature No information available Viscosity No information available

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products. Heat, flames and sparks. Keep away from open flames, hot surfaces and sources of ignition.

Incompatible Materials Strong oxidizing agents, Strong acids, Metals

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), peroxides

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information Acute Toxicity

Product Information Oral LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.

Dermal LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.

Vapor LC50 Based on ATE data, the classification criteria are not met. ATE > 20 mg/l.

Component Information

Component LD50 Oral LD50 Dermal LC50 Inhalation Isopropyl alcohol 5045 mg/kg ( Rat )

3600 mg/kg ( Mouse ) 12800 mg/kg ( Rat ) 72.6 mg/L ( Rat ) 4 h

Water - - - Toxicologically Synergistic Products

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Severe eye irritant

Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico Isopropyl alcohol 67-63-0 Not listed Not listed Not listed Not listed Not listed

Water 7732-18-5 Not listed Not listed Not listed Not listed Not listed Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure Central nervous system (CNS) STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and Inhalation of high vapor concentrations may cause symptoms like headache, dizziness, Page 5 / 9 delayed tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information Ecotoxicity

Component Freshwater Algae Freshwater Fish Microtox Water Flea Isopropyl alcohol EC50: > 1000 mg/L, 72h

(Desmodesmus subspicatus)

EC50: > 1000 mg/L, 96h (Desmodesmus subspicatus)

LC50: = 9640 mg/L, 96h flow-through (Pimephales promelas) LC50: > 1400000 µg/L, 96h

(Lepomis macrochirus) LC50: = 11130 mg/L, 96h static (Pimephales promelas)

LC50: = 10000000 µg/L, 96h (Daphnia)

= 35390 mg/L EC50 Photobacterium phosphoreum 5 min

13299 mg/L EC50 = 48 h 9714 mg/L EC50 = 24 h

Persistence and Degradability Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its volatility.

Component log Pow Isopropyl alcohol 0.05

13. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

14. Transport information

DOT

UN-No UN1219 Proper Shipping Name ISOPROPANOL Hazard Class 3 Packing Group II

TDG

UN-No UN1219 Proper Shipping Name ISOPROPANOL Hazard Class 3 Packing Group II

IATA

UN-No UN1219 Proper Shipping Name ISOPROPANOL Hazard Class 3 Packing Group II

IMDG/IMO

UN-No UN1219 Proper Shipping Name ISOPROPANOL Hazard Class 3 Packing Group II

15. Regulatory information

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United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - Active-Inactive

TSCA - EPA Regulatory Flags

Isopropyl alcohol 67-63-0 X ACTIVE - Water 7732-18-5 X ACTIVE -

Legend:

TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed

TSCA - Per 40 CFR 751, Regulation of Certain Chemical Substances & Mixtures, Under TSCA Section 6(h) (PBT)

Not applicable

TSCA 12(b) - Notices of Export Not applicable

International Inventories Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea

(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL Isopropyl alcohol 67-63-0 X - 200-661-7 X X X X X KE-29363

Water 7732-18-5 X - 231-791-2 X X X X KE-35400

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313

Component CAS No Weight % SARA 313 - Threshold

Values % Isopropyl alcohol 67-63-0 64.7 1.0

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Not applicable

Clean Air Act Not applicable

OSHA - Occupational Safety and Health Administration

Not applicable

CERCLA Not applicable

California Proposition 65 This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Isopropyl alcohol X X X - X

Water - - X - -

U.S. Department of Transportation Reportable Quantity (RQ): N DOT Marine Pollutant N DOT Severe Marine Pollutant N

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U.S. Department of Homeland Security

This product does not contain any DHS chemicals.

Other International Regulations

Mexico - Grade Serious risk, Grade 3

Authorisation/Restrictions according to EU REACH

Component CAS No REACH (1907/2006) - Annex XIV - Substances Subject to Authorization

REACH (1907/2006) -

Annex XVII - Restrictions on Certain Dangerous Substances

REACH Regulation (EC 1907/2006) article 59 -

Candidate List of Substances of Very High

Concern (SVHC) Isopropyl alcohol 67-63-0 - Use restricted. See item

75.

(see link for restriction details)

Water 7732-18-5 - - -

REACH links https://echa.europa.eu/substances-restricted-under-reach

Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Pollutant

Ozone Depletion Potential

Restriction of Hazardous

Substances (RoHS) Isopropyl alcohol 67-63-0 Listed Not applicable Not applicable Not applicable

Water 7732-18-5 Listed Not applicable Not applicable Not applicable

Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)?

Not applicable

Other International Regulations

Component CAS No Seveso III Directive

(2012/18/EC) -

Qualifying Quantities for Major Accident

Notification

Seveso III Directive

(2012/18/EC) -

Qualifying Quantities for Safety Report

Requirements

Rotterdam Convention (PIC)

Basel Convention (Hazardous Waste)

Isopropyl alcohol 67-63-0 Not applicable Not applicable Not applicable Annex I - Y42 Water 7732-18-5 Not applicable Not applicable Not applicable Not applicable

16. Other information Prepared By Regulatory Affairs

Thermo Fisher Scientific Email: EMSDS.RA@thermofisher.com

Creation Date 28-Jan-2010 Revision Date 13-Oct-2023 Print Date 13-Oct-2023 Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard replacing the current legislation under 29 CFR 1910.1200 to align with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

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Disclaimer

The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

End of SDS

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