Formalin SDS.pdf

SAFETY DATA SHEET

Creation Date 17-Nov-2015 Revision Date 20-Feb-2018 Revision Number 4

1. Identification Product Name 10% Neutral Buffered Formalin

Cat No. : 22-110-761; 22-110-757; 22-110-758; 22-110-759; 22-110-760;

22-046-333; 22-046-324; 22-046-335; 22-046-327; 22-046-337;

22-046-329; 22-046-331; 22-050-258; 22-050-136; 22-050-137;

22-050-138; 22-050-139; 22-050-104; 22-050-105; 22-110-869;

22-110-614; 22-220-685; 22-220-686; 22-220-682; 22-220-683;

22-220-684; 22-050-196; 22-110-664; 22-110-873; 22-045-408;

22-045-400; 22-045-401; 22-045-402; 22-110-689; 22-045-403, 22-045-405, 032-059, 032-060, 005-500, 011-120, 111-123, 245-684, 245-685, 253-998, 305-510, 316-154, 316-155, 316-156, 426-796, 426-797, 427-098

Synonyms No information available

Recommended Use Laboratory chemicals.

Uses advised against Not for food, drug, pesticide or biocidal product use

Details of the supplier of the safety data sheet

Emergency Telephone Number Chemtrec US: (800) 424-9300 Chemtrec EU: 001 (202) 483-7616

2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Label Elements

Signal Word Danger

Company Richard Allan Scientific A Subsidiary of Thermo Fisher Scientific 4481 Campus Drive Kalamazoo, MI 49008 Tel: (800) 522-7270

Skin Corrosion/irritation Category 2 Serious Eye Damage/Eye Irritation Category 1 Skin Sensitization Category 1 Germ Cell Mutagenicity Category 2 Carcinogenicity Category 1A Specific target organ toxicity (single exposure) Category 1 Target Organs - Respiratory system, Central nervous system (CNS).

Specific target organ toxicity - (repeated exposure) Category 2 Target Organs - Kidney, Liver, spleen, Blood.

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10% Neutral Buffered Formalin Revision Date 20-Feb-2018

Hazard Statements Causes serious eye damage Causes skin irritation May cause respiratory irritation May cause drowsiness or dizziness May cause an allergic skin reaction May cause cancer Suspected of causing genetic defects Causes damage to organs May cause damage to organs through prolonged or repeated exposure

Precautionary Statements Prevention Obtain special instructions before use Do not handle until all safety precautions have been read and understood Use personal protective equipment as required Wash face, hands and any exposed skin thoroughly after handling Contaminated work clothing should not be allowed out of the workplace Wear protective gloves Do not breathe dust/fume/gas/mist/vapors/spray Do not eat, drink or smoke when using this product Use only outdoors or in a well-ventilated area Response IF exposed: Call a POISON CENTER or doctor/physician Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Call a POISON CENTER or doctor/physician if you feel unwell Skin IF ON SKIN: Wash with plenty of soap and water Take off contaminated clothing and wash before reuse If skin irritation or rash occurs: Get medical advice/attention Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing Immediately call a POISON CENTER or doctor/physician Storage Store locked up Store in a well-ventilated place. Keep container tightly closed Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC)

WARNING. Cancer - https://www.p65warnings.ca.gov/.

3. Composition/Information on Ingredients

Component CAS-No Weight % Water 7732-18-5 94 - 95

Formaldehyde 50-00-0 3.5 - 4 Methyl alcohol 67-56-1 1.2

Sodium phosphate dibasic 7558-79-4 < 1

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Sodium phosphate, monobasic 7558-80-7 < 1

4. First-aid measures

General Advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is required.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.

Inhalation Move to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Immediate medical attention is required.

Ingestion Do not induce vomiting. Call a physician or Poison Control Center immediately.

Most important symptoms and effects

Causes eye burns. May cause allergic skin reaction. Breathing difficulties. . Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing: Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting

Notes to Physician Treat symptomatically

5. Fire-fighting measures Suitable Extinguishing Media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Unsuitable Extinguishing Media No information available

Flash Point > 93.3 °C / > 199.9 °F

Method - No information available

Autoignition Temperature No information available Explosion Limits

Upper No data available Lower No data available Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical Thermal decomposition can lead to release of irritating gases and vapors. Keep product and empty container away from heat and sources of ignition. Risk of ignition.

Hazardous Combustion Products Formaldehyde Methanol Carbon monoxide (CO) Carbon dioxide (CO2) Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA

6. Accidental release measures Personal Precautions Use personal protective equipment. Ensure adequate ventilation. Evacuate personnel to

Health

Flammability

Instability

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Physical hazards N/A safe areas. Keep people away from and upwind of spill/leak.

Environmental Precautions Should not be released into the environment. Do not flush into surface water or sanitary sewer system. See Section 12 for additional ecological information.

Methods for Containment and Clean Up

Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.

7. Handling and storage Handling Use only under a chemical fume hood. Wear personal protective equipment. Do not breathe vapors or spray mist. Do not get in eyes, on skin, or on clothing. Do not ingest.

Storage Keep containers tightly closed in a dry, cool and well-ventilated place.

8. Exposure controls / personal protection Exposure Guidelines

9. Physical and chemical properties Physical State Liquid Appearance Clear Colorless Odor Characteristic formaldehyde Odor Threshold No information available

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA) Formaldehyde TWA: 0.1 ppm

STEL: 0.3 ppm (Vacated) TWA: 3 ppm

(Vacated) STEL: 10 ppm (Vacated) Ceiling: 5 ppm

TWA: 0.75 ppm STEL: 2 ppm

IDLH: 20 ppm TWA: 0.016 ppm Ceiling: 0.1 ppm

Ceiling: 2 ppm Ceiling: 3 mg/m3

Methyl alcohol TWA: 200 ppm STEL: 250 ppm

Skin

(Vacated) TWA: 200 ppm (Vacated) TWA: 260 mg/m3

(Vacated) STEL: 250 ppm (Vacated) STEL: 325 mg/m3

Skin TWA: 200 ppm

TWA: 260 mg/m3

IDLH: 6000 ppm TWA: 200 ppm

TWA: 260 mg/m3

STEL: 250 ppm STEL: 325 mg/m3

TWA: 200 ppm TWA: 260 mg/m3

STEL: 250 ppm STEL: 310 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and Health Administration NIOSH IDLH: The National Institute for Occupational Safety and Health Immediately Dangerous to Life or Health

Engineering Measures Use only under a chemical fume hood. Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Tightly fitting safety goggles.

Skin and body protection Long sleeved clothing.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures

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Handle in accordance with good industrial hygiene and safety practice.

pH 7 Melting Point/Range No data available Boiling Point/Range Not applicable Flash Point > 93.3 °C / > 199.9 °F Evaporation Rate No information available Flammability (solid,gas) Not applicable Flammability or explosive limits

Upper No data available Lower No data available

Vapor Pressure No information available Vapor Density No information available Specific Gravity No information available Solubility miscible Partition coefficient; n-octanol/water No data available Autoignition Temperature No information available Decomposition Temperature No information available Viscosity No information available Molecular Formula Solution

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Stable under normal conditions.

Conditions to Avoid Incompatible products. Excess heat.

Incompatible Materials Strong oxidizing agents, Strong acids, Strong bases

Hazardous Decomposition Products Formaldehyde, Methanol, Carbon monoxide (CO), Carbon dioxide (CO2)

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information Acute Toxicity

Product Information No acute toxicity information is available for this product Oral LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.

Dermal LD50 Based on ATE data, the classification criteria are not met. ATE > 2000 mg/kg.

Vapor LC50 Based on ATE data, the classification criteria are not met. ATE > 20 mg/l.

Component Information

Component LD50 Oral LD50 Dermal LC50 Inhalation Water - Not listed Not listed

Formaldehyde 500 mg/kg ( Rat ) LD50 = 270 mg/kg ( Rabbit ) 0.578 mg/L ( Rat ) 4 h

Methyl alcohol Calc. ATE 60 mg/kg LD50 > 1187 – 2769 mg/kg ( Rat )

Calc. ATE 60 mg/kg LD50 = 17100 mg/kg ( Rabbit )

Calc. ATE 0.6 mg/L (vapours) or

0.5 mg/L (mists)

LC50 = 128.2 mg/L ( Rat ) 4 h Sodium phosphate dibasic LD50 = 17 g/kg ( Rat ) Not listed Not listed

Sodium phosphate, monobasic LD50 = 8290 mg/kg ( Rat ) LD50 > 7940 mg/kg ( Rabbit ) Not listed

Toxicologically Synergistic Products

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Irritating to eyes, respiratory system and skin

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Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA Mexico Water 7732-18-5 Not listed Not listed Not listed Not listed Not listed

Formaldehyde 50-00-0 Group 1 Known A1 X A2 Methyl alcohol 67-56-1 Not listed Not listed Not listed Not listed Not listed

Sodium phosphate dibasic

7558-79-4 Not listed Not listed Not listed Not listed Not listed

Sodium phosphate, monobasic

7558-80-7 Not listed Not listed Not listed Not listed Not listed

IARC: (International Agency for Research on Cancer) IARC: (International Agency for Research on Cancer) Group 1 - Carcinogenic to Humans Group 2A - Probably Carcinogenic to Humans Group 2B - Possibly Carcinogenic to Humans

NTP: (National Toxicity Program) NTP: (National Toxicity Program) Known - Known Carcinogen Reasonably Anticipated - Reasonably Anticipated to be a Human Carcinogen

ACGIH: (American Conference of Governmental Industrial Hygienists)

A1 - Known Human Carcinogen A2 - Suspected Human Carcinogen A3 - Animal Carcinogen ACGIH: (American Conference of Governmental Industrial Hygienists)

Mexico - Occupational Exposure Limits - Carcinogens Mexico - Occupational Exposure Limits - Carcinogens A1 - Confirmed Human Carcinogen A2 - Suspected Human Carcinogen A3 - Confirmed Animal Carcinogen A4 - Not Classifiable as a Human Carcinogen A5 - Not Suspected as a Human Carcinogen

Mutagenic Effects Mutagenic effects have occurred in humans.

Reproductive Effects Experiments have shown reproductive toxicity effects on laboratory animals.

Developmental Effects Developmental effects have occurred in experimental animals.

Teratogenicity Teratogenic effects have occurred in experimental animals.

STOT - single exposure Respiratory system Central nervous system (CNS) STOT - repeated exposure Kidney Liver spleen Blood

Aspiration hazard No information available

Symptoms / effects,both acute and delayed

Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing:

Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting

Endocrine Disruptor Information No information available

Other Adverse Effects Tumorigenic effects have been reported in experimental animals. The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.

12. Ecological information Ecotoxicity Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. The product contains following substances which are hazardous for the environment. Contains a substance which is:. Toxic to aquatic organisms.

Component Freshwater Algae Freshwater Fish Microtox Water Flea Formaldehyde Not listed Leuciscus idus: LC50 = 15 mg/L 96h Not listed EC50 = 20 mg/L 96h

EC50 = 2 mg/L 48h Methyl alcohol Not listed Pimephales promelas: LC50

> 10000 mg/L 96h EC50 = 39000 mg/L 25 min EC50 = 40000 mg/L 15 min

EC50 > 10000 mg/L 24h

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EC50 = 43000 mg/L 5 min

Persistence and Degradability Miscible with water Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility . Will likely be mobile in the environment due to its water solubility.

Component log Pow Formaldehyde -0.35 Methyl alcohol -0.74

13. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

Component RCRA - U Series Wastes RCRA - P Series Wastes Formaldehyde - 50-00-0 U122 - Methyl alcohol - 67-56-1 U154 -

14. Transport information DOT Not regulated TDG Not regulated IATA Not regulated IMDG/IMO Not regulated

15. Regulatory information

All of the components in the product are on the following Inventory lists: X = listed

International Inventories

Component TSCA DSL NDSL EINECS ELINCS NLP PICCS ENCS AICS IECSC KECL Water X X - 231-791-2 - X - X X X

Formaldehyde X X - 200-001-8 - X X X X X Methyl alcohol X X - 200-659-6 - X X X X X

Sodium phosphate dibasic X X - 231-448-7 - X X X X X Sodium phosphate, monobasic X X - 231-449-2 - X X X X X

Legend:

X - Listed E - Indicates a substance that is the subject of a Section 5(e) Consent order under TSCA.

F - Indicates a substance that is the subject of a Section 5(f) Rule under TSCA.

N - Indicates a polymeric substance containing no free-radical initiator in its inventory name but is considered to cover the designated polymer made with any free-radical initiator regardless of the amount used.

P - Indicates a commenced PMN substance R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.

S - Indicates a substance that is identified in a proposed or final Significant New Use Rule T - Indicates a substance that is the subject of a Section 4 test rule under TSCA.

XU - Indicates a substance exempt from reporting under the Inventory Update Rule, i.e. Partial Updating of the TSCA Inventory Data Base Production and Site Reports (40 CFR 710(B).

Y1 - Indicates an exempt polymer that has a number-average molecular weight of 1,000 or greater.

Y2 - Indicates an exempt polymer that is a polyester and is made only from reactants included in a specified list of low concern reactants that comprises one of the eligibility criteria for the exemption rule.

U.S. Federal Regulations

TSCA 12(b) Not applicable

SARA 313

Component CAS-No Weight % SARA 313 - Threshold

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Values % Formaldehyde 50-00-0 3.5 - 4 0.1

Methyl alcohol 67-56-1 1.2 1.0

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Component CWA - Hazardous

Substances CWA - Reportable

Quantities CWA - Toxic Pollutants CWA - Priority Pollutants

Formaldehyde X 100 lb - -

Sodium phosphate dibasic X 5000 lb - -

Clean Air Act Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors

Formaldehyde X -

Methyl alcohol X -

OSHA Occupational Safety and Health Administration

Component Specifically Regulated Chemicals Highly Hazardous Chemicals

Formaldehyde 2 ppm STEL

0.5 ppm Action Level

0.75 ppm TWA

TQ: 1000 lb

CERCLA This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302)

Component Hazardous Substances RQs CERCLA EHS RQs

Formaldehyde 100 lb 100 lb

Methyl alcohol 5000 lb -

Sodium phosphate dibasic 5000 lb -

California Proposition 65 This product contains the following proposition 65 chemicals

Component CAS-No California Prop. 65 Prop 65 NSRL Category

Formaldehyde 50-00-0 Carc. (Gaseous only) 40 µg/day Carcinogen

Methyl alcohol 67-56-1 Developmental - Developmental

U.S. State Right-to-Know Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Water - - X - -

Formaldehyde X X X X X

Methyl alcohol X X X X X

Sodium phosphate dibasic

X X X - -

U.S. Department of Transportation

Reportable Quantity (RQ): Y DOT Marine Pollutant N DOT Severe Marine Pollutant N

U.S. Department of Homeland Security This product contains the following DHS chemicals:

Component DHS Chemical Facility Anti-Terrorism Standard Formaldehyde 11250 lb STQ (solution)

Sodium phosphate, monobasic 2000 lb STQ Other International Regulations

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Mexico - Grade Slight risk, Grade 1

16. Other information Prepared By Regulatory Affairs

Thermo Fisher Scientific Email: EMSDS.RA@thermofisher.com Richard Allan Scientific A Subsidiary of Thermo Fisher Scientific Tel: (800) 522-7270

Creation Date 17-Nov-2015 Revision Date 20-Feb-2018 Print Date 20-Feb-2018 Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard replacing the current legislation under 29 CFR 1910.1200 to align with the Globally Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

End of SDS

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