Attachment_C.pdf

2007 Data Evaluation Reports National Program of Cancer Registries

Cancer Surveillance System

Kentucky

Department of Health and Human Services Centers for Disease Control and Prevention

Safer · Healthier · People

Data Evaluation Reports - Kentucky

Introduction ………………………………………………………………….……………………………………………. Introduction: 1-2

2007 - Standard Status Report (SSR1) …………………………………………….……………………………………………. SSR1: 1 Report on Quality, Completeness and Timeliness ……..….………………..……………………………………… SSR1: 2 2007 CSS Submission Average with Range ……………….…………....…..…………………………………… SSR1: 3 Estimated Completeness - 2005 ……………………………………………………………..………………………….. SSR1: 4-6 Estimated Completeness - 2004 ……………………………………………………………..………………………….. SSR1: 7-9 Estimated Completeness - 2003 ……………………………………………………………..………………………….. SSR1: 10-12 Estimated Completeness - 2002 ……………………………………………………………..………………………….. SSR1: 13-15 Estimated Completeness - 2001 ……………………………………………………………..………………………….. SSR1: 16-18 Estimated Completeness - 2000 ……………………………………………………………..………………………….. SSR1: 19-21

2007 - Submission Summary Report (SSR2) ………………………..…......………………….……………………………… SSR2: 1 Table 1: Submission Summary …………………….…………….….………………………..……………………… SSR2: 2 Table 2a: Number and Percentage Core Single and Inter-field Errors …………………...………………………………SSR2: 3 Table 2b: Number and Percentage Advanced Single and Inter-field Errors …………...…………………………………SSR2: 4 Table 2c: Core Inter-Record Edit Errors by Error Type Among

Individuals with Multiple Primaries ………………………..……………………………………… SSR2: 5 Table 2d: Advanced Inter-Record Edit Errors by Error Type Among

Individuals with Multiple Primaries ………………………..……………………………………… SSR2: 6 Table 3: Percentage of Over-Ride Flagged Fields -- Grouped by Edit Name and Diagnosis Year …………….….. SSR2: 7 Table 4: Average Percentage of Over-Ride Flags for All 2007 NPCR Data Submissions ……………..……….…. SSR2: 8

2007 - Data Quality Indicator Report (DQI) ………………………………..…......………………….……………………… DQI: 1 Table 1: Core Cancer Surveillance Data …………………….…………….….………………………..…………………DQI: 2-3 Table 2: Advanced Cancer Surveillance Data ……………………………………...……………………………………DQI: 4-5

Department of Health and Human Services Centers for Disease Control and Prevention

NPCR-CSS Data Evaluation Report 2007 (DER 2007)

Introduction

The National Program of Cancer Registries (NPCR) provides funds to state and territorial health departments to improve or enhance existing cancer registries; plan for and implement registries where they did not exist; develop model legislation and regulations for states and territories to enhance the viability of registry operations; set standards for data completeness, timeliness, and quality; provide training for registry personnel; and help establish a computerized reporting and data-processing system.

NPCR’s goals are to rapidly establish and standardize the reporting of cancer within and among the states in order to build state and national capacity to do the following: monitor the cancer burden; identify cancer incidence variation for racial and ethnic populations and for regions within a state, between states, and between regions; provide data for research; provide guidance for health resource allocation; respond to public concern and inquiries about cancer; improve planning for future health care needs; and evaluate cancer prevention and control activities.

In 2000, CDC established the NPCR-Cancer Surveillance System (NPCR-CSS) to receive, evaluate, and disseminate data from registries participating in NPCR. The NPCR-CSS is designed to provide cancer incidence data to meet CDC’s public health surveillance responsibilities and to help monitor progress toward NPCR goals. Beginning January 2001, registries annually report their incidence data to CDC from their NPCR reference year forward. The “NPCR reference year” is the first diagnosis year for which a state or territorial cancer registry collected data with the assistance of NPCR funds.

Following each data submission, registries receive a NPCR- CSS Data Evaluation Report detailing the completeness, accuracy and timeliness of their data submission, as demonstrated by meeting the following 5 data quality criteria for each diagnosis year for all cancer sites combined:

· Percent Completeness Adjusted for Duplicates: The percentage of observed to expected, unduplicated cases where the expected cases are estimated by using methods developed by the North American Association of Central Cancer Registries (NAACCR) (http://www.naaccr.org/). DER 2007 case completeness evaluation is based on NAACCR method version 2.2.

· Unresolved Duplicate Rate: Because some cancer patients receive diagnostic or treatment services at more than one reporting facility, cancer registries perform a procedure to identify and resolve duplicate case reporting to ensure that each cancer case is counted only once. Prior to the submission of data to NPCR-CSS, each registry performs a protocol developed by NAACCR for assessing duplicate cases. This information is reported to CDC at the time of the data submission.

· Percent Death Certificate Only Cases: Another measure of the completeness of case ascertainment is the proportion of cases ascertained solely on the basis of a death certificate, with no other information on the case available after the registry has completed a routine procedure known as “death clearance and follow back”.

Introduction: 1

NPCR-CSS Data Evaluation Report 2007 (DER 2007)

· Percent Missing Critical Data Elements (Age, Sex, Race and County): The proportion of cases missing information deemed critical for the reporting of population-based cancer incidence data.

· Percent Passing Edits: Edits test the validity and logic of data components. Edits are applied to single field variables, inter-field variables and to multiple records (each record denotes a case of cancer in a patient) in those instances when a patient has multiple cancer diagnoses. Inter-record (IR) edits are run on the entire data submission from the reference year through the most current 24-month data. There are two types of edits: core edits that are applied to variables deemed necessary for reporting incidence data; and advanced edits that are applied to variables used for advanced surveillance activities such as survival analyses. At this time, it should be noted that there are no standards for advanced edits.

How the Data Evaluation Reports are used: The Data Evaluation Reports are used to identify cancer registries whose incidence data meet data standards established by NPCR. The NPCR 12 and 24 month standards are applied to data for diagnoses made 12 and 24 months past the close of the diagnosis years being evaluated. For example, for data submitted in January 2007, the NPCR 12 and 24 month standards will be applied to diagnosis years 2005 and 2004, respectively. The USCS publication criteria is a subset of the NPCR 24 month standard. These criteria are used to identify data for inclusion in the United States Cancer Statistics report (http://apps.nccd.cdc.gov/uscs/) published jointly with the National Cancer Institute's Surveillance Epidemiology and End Results (SEER) Program and in collaboration with NAACCR. In establishing these standards and criteria, CDC recognizes that it may take up to two years before a registry’s incidence data are complete (i.e., all the information on a cancer patient has been reported to and processed by the cancer registry).

When reviewing the Report on Quality, Completeness and Timeliness of Data table, the criteria for each standard (NPCR 12 and 24 month) and the USCS publication criteria are highlighted by a color. When all relevant data quality criteria are met, the row corresponding to the diagnosis year will be highlighted. CDC expects that all registries should achieve these NPCR program standards and in so doing be included in the USCS report.

Introduction: 2

2007 - Standard Status Report (SSR1) National Program of Cancer Registries

Cancer Surveillance System

Kentucky

Department of Health and Human Services Centers for Disease Control and Prevention

April 13, 2007 SSR1: 1 of 21

National Program of Cancer Registries - Cancer Surveillance System SSR1 - Standard Status Report - 2007

Kentucky

Report on Quality, Completeness and Timeliness of Data*

12 Months 2005 95.65 0.00 NDC 0.00 0.00 2.16 0.00 99.13 N/A 2004 104.36 0.39 1.02 0.00 0.00 2.37 0.00 100.00 2003 102.82 0.26 1.52 0.00 0.00 1.43 0.00 100.00 2002 102.45 0.26 1.12 0.00 0.00 0.66 0.00 100.00 2001 103.81 0.26 0.76 0.00 0.00 0.76 0.00 100.00 2000 105.47 0.26 0.92 0.00 0.00 0.53 0.00 100.00

90.00 N/A N/A N/A N/A N/A N/A 97.00 N/A

95.00 <=1 <=3 <=2 <=2 <=3 <=2 99.00 99.00

90.00 N/A <=5 <=3 <=3 <=5 N/A 97.00 97.00

-1.0 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 N/A N/A

NDC: Death Clearance Not Done.

N/A: Not Applicable

* See the Introduction section of this report for a description of the data quality criteria and evaluation methods.

** Only data from the most recent six diagnosis years are presented here. Highlighted rows denote the diagnosis years for which data met program and/or publication standards. Colors correspond to the data standard met. Diagnosis years that did not meet program and/or publication standards are not highlighted.

Publication standards are applied to 24 + month data. Data meeting the 24-month standard automatically meet the publication standards.

*** Calculated as (1 - # of patients with a core Inter-record edit error/# of patients with more than one record) x 100.

**** The measurement error is the error allowance for determining if data elements have met the standard.

100.0024+ Months

NPCR 12 Month Standard NPCR 24 Month Standard

USCS Publication Standard Measurement Error****

County

Percent Passing Core Single and Inter-field Edits

STANDARD

NPCR

Standards Grouping

Diagnosis Year**

Percent Completeness Adjusted for Duplicates*

Unresolved Duplicates Rate

(per 1,000)

1995-2004 Percent

Passing Core Inter-record

Edits***

Percent Missing or Unknown Core Data ElementsPercent Death

Certificate Only Cases Age Sex Race

SSR1: 2 of 21

National Program of Cancer Registries - Cancer Surveillance System

CSS Submission Average with Range

Report on Quality, Completeness and Timeliness of Data -- 2007 CSS Submission Average with Range

Average 84.42 0.00 1.67 0.01 0.04 3.18 0.71 99.94 Range 6.46-116.83 0.00-0.00 0.00-5.39 0.00-0.07 0.00-0.47 0.00-41.91 0.00-14.17 98.94-100.00

Average 100.86 0.29 1.96 0.01 0.01 1.49 0.22 99.99 Range 90.22-111.95 0.00-3.32 0.00-4.23 0.00-0.06 0.00-0.12 0.00-4.74 0.00-2.28 99.75-100.00

Average 100.64 0.48 1.81 0.01 0.01 1.29 0.25 99.99 Range 87.78-109.12 0.00-11.20 0.00-4.37 0.00-0.06 0.00-0.09 0.00-4.24 0.00-4.35 99.90-100.00

Average 99.41 0.48 1.91 0.00 0.01 1.07 0.10 99.99 Range 82.50-110.26 0.00-11.20 0.00-9.23 0.00-0.03 0.00-0.10 0.00-3.53 0.00-1.07 99.90-100.00

Average 98.86 0.48 2.08 0.01 0.00 0.98 0.12 100.00 Range 79.62-107.64 0.00-11.20 0.32-8.42 0.00-0.05 0.00-0.06 0.00-2.80 0.00-1.19 99.91-100.00

Average 98.80 0.49 1.74 0.01 0.00 0.83 0.13 100.00 Range 81.19-108.33 0.00-11.20 0.00-8.61 0.00-0.06 0.00-0.03 0.00-2.59 0.00-1.60 99.94-100.00

90.00 N/A N/A N/A N/A N/A N/A 97.00 N/A

95.00 <=1 <=3 <=2 <=2 <=3 <=2 99.00 99.00

90.00 N/A <=5 <=3 <=3 <=5 N/A 97.00 97.00

-1.0 -0.4 -0.4 -0.4 -0.4 -0.4 -0.4 N/A N/A

The average is an unweighted average based on NPCR Programs submitting data.

N/A: Not Applicable.

* Only data from the most recent six diagnosis years are presented here.

** Calculated as (1 - # of patients with a core Inter-record edit error/# of patients with more than one record) x 100.

*** The measurement error is the error allowance for determining if data elements have met the standard.

USCS Publication Standard Measurement Error***

N/A

99.98 99.56-100.00

24+ Months

12 Months

NPCR 12 Month Standard NPCR 24 Month Standard

STANDARD

County

Percent Passing Core Single and Inter-field Edits

Percent Passing Core Inter-record

Edits**

Percent Missing or Unknown Core Data ElementsNPCR

Standards Grouping

Diagnosis Year* Statistic

Percent Completeness Adjusted for Duplicates

Unresolved Duplicates Rate

(per 1,000)

Percent Death Certificate Only

Cases Age Sex Race

SSR1: 3 of 21

National Program of Cancer Registries-Cancer Surveillance System

Estimated Completeness of Case Ascertainment for Blacks Kentucky - 2005

Expected Initial Registry Adj Reg Expected Interim 2005 2003-2004 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 15.13 10.36 1.46 6.81 2.57 26.68 56.73 9.00 0.76 9.86 25.38 59.62 Esophagus 13.18 13.00 1.01 10.22 0.94 12.20 107.99 13.47 0.76 12.38 11.62 113.46 Stomach 11.94 5.33 2.24 11.86 1.44 7.66 155.82 8.80 1.35 5.71 8.20 145.68 Colon and Rectum 79.47 30.78 2.58 32.70 2.18 67.24 118.19 35.56 0.92 30.29 66.16 120.12 Liver 7.46 8.18 0.91 8.86 1.43 11.71 63.70 6.63 1.34 8.73 12.50 59.67 Pancreas 18.77 15.83 1.19 15.47 1.05 16.70 112.42 17.07 0.91 15.53 16.38 114.57 Lung and Bronchus 132.94 117.53 1.13 95.82 1.12 131.45 101.13 125.45 0.76 111.98 125.24 106.15 Melanoma of the Skin Prostate Urinary Bladder 22.78 8.61 2.65 5.34 3.85 33.12 68.79 7.81 0.68 8.07 31.02 73.43 Kidney and Renal Pelvis 34.80 4.49 7.75 6.09 3.37 15.14 229.79 5.53 1.10 4.58 15.45 225.27 Brain and Other Nervous System 1.73 2.32 0.75 3.20 1.52 3.54 48.97 2.11 1.52 2.56 3.90 44.38 Hodgkin's Disease 5.19 0.00 0.00 0.49 5.88 0.00 0.00 0.51 0.96 0.00 0.00 0.00 Non-Hodgkin's Lymphomas 11.58 3.37 3.43 6.54 2.85 9.61 120.44 8.83 0.74 3.20 9.11 127.03 Multiple Myeloma 11.00 11.03 1.00 8.45 1.58 17.43 63.15 9.15 0.92 10.87 17.16 64.12 Leukemias 5.89 9.19 0.64 8.76 1.47 13.53 43.53 9.48 0.92 9.05 13.32 44.21 Sum of Rates for Black Males 371.86 366.00 101.60 355.44 104.62

Expected Initial Registry Adj Reg Expected Interim 2005 2003-2004 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 7.23 0.32 22.51 1.71 3.55 1.14 633.66 1.84 0.93 0.32 1.13 642.66 Esophagus 2.27 2.38 0.95 2.98 1.16 2.76 82.23 2.20 1.36 2.55 2.96 76.75 Stomach 7.79 4.68 1.67 5.79 1.51 7.08 110.03 4.18 1.39 5.04 7.63 102.15 Colon and Rectum 63.60 28.39 2.24 22.93 2.38 67.44 94.30 30.67 0.75 26.96 64.03 99.32 Liver 3.58 3.64 0.98 3.04 1.15 4.18 85.56 2.50 1.22 3.79 4.36 82.01 Pancreas 11.08 12.33 0.90 12.42 1.11 13.74 80.63 11.76 1.06 12.47 13.89 79.73 Lung and Bronchus 70.65 62.65 1.13 39.83 1.38 86.28 81.89 60.63 0.66 58.36 80.36 87.92 Melanoma of the Skin Breast Cervix 11.15 6.97 1.60 4.87 2.07 14.41 77.34 5.95 0.82 6.72 13.89 80.26 Corpus and Uterus, NOS 17.76 6.10 2.91 7.10 2.78 16.92 104.95 6.61 1.08 6.19 17.18 103.38 Ovary 7.42 5.54 1.34 7.44 1.36 7.51 98.79 6.93 1.07 5.63 7.63 97.34 Urinary Bladder 9.27 3.83 2.42 2.81 2.75 10.52 88.14 3.41 0.83 3.70 10.15 91.33 Kidney and Renal Pelvis 11.59 1.88 6.18 2.77 3.54 6.64 174.54 2.98 0.93 1.85 6.54 177.11 Brain and Other Nervous System 1.78 4.48 0.40 2.16 1.62 7.27 24.45 3.97 0.54 4.07 6.61 26.90 Hodgkin's Disease 3.11 0.38 8.19 0.31 7.27 2.76 112.71 0.47 0.66 0.35 2.57 120.99 Non-Hodgkin's Lymphomas 11.65 4.53 2.57 4.28 2.86 12.94 90.03 4.03 1.06 4.58 13.10 88.95 Multiple Myeloma 11.95 4.40 2.72 6.26 1.52 6.67 179.16 5.18 1.21 4.58 6.95 172.02 Leukemias 5.29 7.23 0.73 5.32 1.54 11.14 47.52 5.98 0.89 7.07 10.89 48.59 Sum of Rates for Black Females 257.17 279.41 92.04 269.87 95.30

Sum of Rates for Blacks 313.25 321.75 97.36 311.71 99.86

Black Males

Black Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US)

SSR1: 4 of 21

Estimated Completeness of Case Ascertainment for Whites Kentucky - 2005

Expected Initial Registry Adj Reg Expected Interim 2005 2003-2004 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 15.96 3.96 4.03 3.79 4.05 16.02 99.63 4.45 0.85 3.84 15.54 102.70 Esophagus 7.17 8.04 0.89 7.69 1.03 8.24 87.00 8.02 0.96 7.97 8.17 87.72 Stomach 6.49 4.61 1.41 5.21 1.96 9.05 71.76 4.84 1.08 4.68 9.19 70.66 Colon and Rectum 62.14 25.56 2.43 22.94 2.54 64.80 95.89 27.34 0.84 24.74 62.72 99.08 Liver 4.94 5.08 0.97 5.26 1.33 6.77 72.98 5.00 1.05 5.13 6.84 72.24 Pancreas 10.01 12.16 0.82 12.02 1.05 12.77 78.35 11.61 1.04 12.25 12.86 77.80 Lung and Bronchus 114.27 108.56 1.05 72.59 1.01 109.91 103.97 113.05 0.64 100.79 102.04 111.99 Melanoma of the Skin 24.26 4.97 4.88 4.34 6.21 30.90 78.52 5.08 0.85 4.83 30.00 80.87 Prostate Urinary Bladder 37.52 7.78 4.82 7.88 5.06 39.32 95.43 7.99 0.99 7.76 39.21 95.71 Kidney and Renal Pelvis 19.38 7.41 2.62 6.21 2.82 20.90 92.74 7.12 0.87 7.22 20.36 95.18 Brain and Other Nervous System 7.18 5.11 1.40 5.79 1.44 7.33 97.86 5.82 0.99 5.10 7.32 97.96 Hodgkin's Disease 3.48 0.81 4.28 0.58 5.63 4.59 75.93 0.80 0.72 0.77 4.33 80.41 Non-Hodgkin's Lymphomas 22.58 10.03 2.25 9.95 2.50 25.07 90.07 10.23 0.97 9.97 24.93 90.58 Multiple Myeloma 6.14 4.58 1.34 4.35 1.55 7.10 86.49 4.87 0.89 4.49 6.95 88.35 Leukemias 13.53 9.57 1.41 10.30 1.64 15.73 85.99 10.34 1.00 9.56 15.72 86.06 Sum of Rates for White Males 355.06 378.51 93.81 366.19 96.96

Expected Initial Registry Adj Reg Expected Interim 2005 2003-2004 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 5.71 1.61 3.54 1.49 4.13 6.66 85.80 1.61 0.93 1.59 6.56 87.04 Esophagus 1.73 1.46 1.18 1.65 1.18 1.73 100.12 1.36 1.21 1.52 1.80 95.99 Stomach 3.34 2.37 1.41 2.62 1.86 4.41 75.63 2.38 1.10 2.41 4.50 74.17 Colon and Rectum 45.30 18.47 2.45 15.92 2.70 49.95 90.69 18.91 0.84 17.89 48.37 93.65 Liver 2.17 2.26 0.96 1.89 1.25 2.82 76.81 2.22 0.85 2.20 2.74 79.14 Pancreas 8.20 9.15 0.90 9.00 1.08 9.92 82.64 8.80 1.02 9.19 9.96 82.27 Lung and Bronchus 72.35 56.13 1.29 42.15 1.20 67.30 107.51 55.51 0.76 53.43 64.06 112.95 Melanoma of the Skin 17.38 2.08 8.34 1.98 9.05 18.85 92.21 2.24 0.88 2.04 18.42 94.39 Breast Cervix 8.42 2.65 3.18 2.32 3.52 9.33 90.25 2.64 0.88 2.59 9.10 92.53 Corpus and Uterus, NOS 20.77 3.66 5.68 3.87 6.48 23.69 87.67 3.46 1.12 3.75 24.26 85.59 Ovary 10.99 9.05 1.21 9.23 1.55 14.03 78.30 8.98 1.03 9.10 14.11 77.87 Urinary Bladder 8.83 2.67 3.31 2.26 4.36 11.62 75.94 2.53 0.89 2.61 11.38 77.59 Kidney and Renal Pelvis 10.16 3.01 3.37 2.81 3.14 9.46 107.36 3.25 0.86 2.93 9.20 110.37 Brain and Other Nervous System 4.67 3.94 1.19 3.88 1.51 5.94 78.55 3.87 1.00 3.94 5.95 78.51 Hodgkin's Disease 1.80 0.37 4.83 0.39 6.56 2.45 73.65 0.38 1.03 0.38 2.47 73.19 Non-Hodgkin's Lymphomas 14.26 6.02 2.37 6.41 2.68 16.10 88.57 6.56 0.98 5.99 16.02 88.99 Multiple Myeloma 3.78 3.15 1.20 2.84 1.48 4.65 81.28 3.08 0.92 3.10 4.58 82.58 Leukemias 7.73 6.30 1.23 5.83 1.73 10.89 70.94 6.03 0.97 6.26 10.82 71.42 Sum of Rates for White Females 247.58 269.81 91.76 264.29 93.68

Sum of Rates for Whites 300.32 323.15 92.94 314.29 95.29

White Males

White Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality

SSR1: 5 of 21

Kentucky - 2005

Estimated Completeness Summary

Total Adjusted Incident Cases 19690 Total Incident Cases 19690

Race Proportional Completeness, Expected Adjusted for Reference Mortality 95.65 Incident Cases 20586

Final Completeness Estimates, Adjusted for Reference Mortality

%Unresolved Duplicates* 0.00 and Duplicate Records 95.65

* 0.00 indicates all duplicates are resolved.

95.65 4,092,257

Final Completeness Estimates Adjusted for Reference Mortality and Duplicate Records

95.29 3,770,445 99.86 321,812

Percent Complete Population

Percent Complete Population

Percent Complete Population

Interim Completeness Estimates Adjusted for Reference Mortality Whites Blacks Race Proportional

SSR1: 6 of 21

Estimated Completeness of Case Ascertainment for Blacks Kentucky - 2004

Expected Initial Registry Adj Reg Expected Interim 2004 2003-2004 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 17.95 10.36 1.73 6.81 2.57 26.68 67.30 9.00 0.76 9.86 25.38 70.73 Esophagus 8.27 13.00 0.64 10.22 0.94 12.20 67.75 13.47 0.76 12.38 11.62 71.18 Stomach 13.38 5.33 2.51 11.86 1.44 7.66 174.62 8.80 1.35 5.71 8.20 163.26 Colon and Rectum 73.17 30.78 2.38 32.70 2.18 67.24 108.82 35.56 0.92 30.29 66.16 110.60 Liver 8.47 8.18 1.03 8.86 1.43 11.71 72.32 6.63 1.34 8.73 12.50 67.75 Pancreas 9.26 15.83 0.59 15.47 1.05 16.70 55.49 17.07 0.91 15.53 16.38 56.55 Lung and Bronchus 144.03 117.53 1.23 95.82 1.12 131.45 109.57 125.45 0.76 111.98 125.24 115.00 Melanoma of the Skin Prostate Urinary Bladder 24.40 8.61 2.83 5.34 3.85 33.12 73.68 7.81 0.68 8.07 31.02 78.65 Kidney and Renal Pelvis 26.64 4.49 5.94 6.09 3.37 15.14 175.93 5.53 1.10 4.58 15.45 172.47 Brain and Other Nervous System 3.96 2.32 1.70 3.20 1.52 3.54 111.81 2.11 1.52 2.56 3.90 101.32 Hodgkin's Disease 2.23 0.00 0.00 0.49 5.88 0.00 0.00 0.51 0.96 0.00 0.00 0.00 Non-Hodgkin's Lymphomas 24.47 3.37 7.26 6.54 2.85 9.61 254.56 8.83 0.74 3.20 9.11 268.49 Multiple Myeloma 8.02 11.03 0.73 8.45 1.58 17.43 46.01 9.15 0.92 10.87 17.16 46.72 Leukemias 11.91 9.19 1.30 8.76 1.47 13.53 88.03 9.48 0.92 9.05 13.32 89.40 Sum of Rates for Black Males 376.16 366.00 102.78 355.44 105.83

Expected Initial Registry Adj Reg Expected Interim 2004 2003-2004 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 4.19 0.32 13.04 1.71 3.55 1.14 367.04 1.84 0.93 0.32 1.13 372.25 Esophagus 3.99 2.38 1.68 2.98 1.16 2.76 144.31 2.20 1.36 2.55 2.96 134.69 Stomach 10.01 4.68 2.14 5.79 1.51 7.08 141.38 4.18 1.39 5.04 7.63 131.26 Colon and Rectum 59.77 28.39 2.11 22.93 2.38 67.44 88.63 30.67 0.75 26.96 64.03 93.34 Liver 1.93 3.64 0.53 3.04 1.15 4.18 46.24 2.50 1.22 3.79 4.36 44.32 Pancreas 14.70 12.33 1.19 12.42 1.11 13.74 107.04 11.76 1.06 12.47 13.89 105.83 Lung and Bronchus 90.56 62.65 1.45 39.83 1.38 86.28 104.97 60.63 0.66 58.36 80.36 112.70 Melanoma of the Skin Breast Cervix 13.67 6.97 1.96 4.87 2.07 14.41 94.85 5.95 0.82 6.72 13.89 98.44 Corpus and Uterus, NOS 19.99 6.10 3.28 7.10 2.78 16.92 118.13 6.61 1.08 6.19 17.18 116.37 Ovary 8.30 5.54 1.50 7.44 1.36 7.51 110.53 6.93 1.07 5.63 7.63 108.90 Urinary Bladder 7.72 3.83 2.02 2.81 2.75 10.52 73.44 3.41 0.83 3.70 10.15 76.10 Kidney and Renal Pelvis 12.79 1.88 6.82 2.77 3.54 6.64 192.68 2.98 0.93 1.85 6.54 195.53 Brain and Other Nervous System 4.02 4.48 0.90 2.16 1.62 7.27 55.24 3.97 0.54 4.07 6.61 60.79 Hodgkin's Disease 3.57 0.38 9.40 0.31 7.27 2.76 129.28 0.47 0.66 0.35 2.57 138.78 Non-Hodgkin's Lymphomas 10.30 4.53 2.27 4.28 2.86 12.94 79.60 4.03 1.06 4.58 13.10 78.65 Multiple Myeloma 9.64 4.40 2.19 6.26 1.52 6.67 144.57 5.18 1.21 4.58 6.95 138.81 Leukemias 5.51 7.23 0.76 5.32 1.54 11.14 49.51 5.98 0.89 7.07 10.89 50.62 Sum of Rates for Black Females 280.69 279.41 100.46 269.87 104.01

Sum of Rates for Blacks 327.37 321.75 101.75 311.71 104.90

Black Males

Black Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality

SSR1: 7 of 21

Estimated Completeness of Case Ascertainment for Whites Kentucky - 2004

Expected Initial Registry Adj Reg Expected Interim 2004 2003-2004 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 17.13 3.96 4.33 3.79 4.05 16.02 106.90 4.45 0.85 3.84 15.54 110.19 Esophagus 8.66 8.04 1.08 7.69 1.03 8.24 105.08 8.02 0.96 7.97 8.17 105.95 Stomach 8.04 4.61 1.74 5.21 1.96 9.05 88.83 4.84 1.08 4.68 9.19 87.47 Colon and Rectum 68.31 25.56 2.67 22.94 2.54 64.80 105.42 27.34 0.84 24.74 62.72 108.92 Liver 5.82 5.08 1.15 5.26 1.33 6.77 85.87 5.00 1.05 5.13 6.84 85.00 Pancreas 12.22 12.16 1.00 12.02 1.05 12.77 95.70 11.61 1.04 12.25 12.86 95.03 Lung and Bronchus 132.94 108.56 1.22 72.59 1.01 109.91 120.95 113.05 0.64 100.79 102.04 130.27 Melanoma of the Skin 23.85 4.97 4.79 4.34 6.21 30.90 77.20 5.08 0.85 4.83 30.00 79.51 Prostate Urinary Bladder 38.42 7.78 4.94 7.88 5.06 39.32 97.69 7.99 0.99 7.76 39.21 97.98 Kidney and Renal Pelvis 18.72 7.41 2.53 6.21 2.82 20.90 89.57 7.12 0.87 7.22 20.36 91.93 Brain and Other Nervous System 7.71 5.11 1.51 5.79 1.44 7.33 105.17 5.82 0.99 5.10 7.32 105.28 Hodgkin's Disease 3.06 0.81 3.76 0.58 5.63 4.59 66.81 0.80 0.72 0.77 4.33 70.75 Non-Hodgkin's Lymphomas 23.70 10.03 2.36 9.95 2.50 25.07 94.56 10.23 0.97 9.97 24.93 95.09 Multiple Myeloma 6.48 4.58 1.41 4.35 1.55 7.10 91.26 4.87 0.89 4.49 6.95 93.22 Leukemias 15.73 9.57 1.64 10.30 1.64 15.73 99.98 10.34 1.00 9.56 15.72 100.06 Sum of Rates for White Males 390.79 378.51 103.24 366.19 106.72

Expected Initial Registry Adj Reg Expected Interim 2004 2003-2004 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 6.05 1.61 3.75 1.49 4.13 6.66 90.87 1.61 0.93 1.59 6.56 92.19 Esophagus 2.28 1.46 1.56 1.65 1.18 1.73 132.25 1.36 1.21 1.52 1.80 126.80 Stomach 3.57 2.37 1.51 2.62 1.86 4.41 80.79 2.38 1.10 2.41 4.50 79.23 Colon and Rectum 49.57 18.47 2.68 15.92 2.70 49.95 99.24 18.91 0.84 17.89 48.37 102.48 Liver 1.70 2.26 0.75 1.89 1.25 2.82 60.21 2.22 0.85 2.20 2.74 62.03 Pancreas 8.65 9.15 0.95 9.00 1.08 9.92 87.24 8.80 1.02 9.19 9.96 86.85 Lung and Bronchus 74.65 56.13 1.33 42.15 1.20 67.30 110.93 55.51 0.76 53.43 64.06 116.54 Melanoma of the Skin 17.17 2.08 8.24 1.98 9.05 18.85 91.08 2.24 0.88 2.04 18.42 93.24 Breast Cervix 9.61 2.65 3.63 2.32 3.52 9.33 102.97 2.64 0.88 2.59 9.10 105.57 Corpus and Uterus, NOS 23.85 3.66 6.52 3.87 6.48 23.69 100.70 3.46 1.12 3.75 24.26 98.32 Ovary 13.16 9.05 1.45 9.23 1.55 14.03 93.76 8.98 1.03 9.10 14.11 93.25 Urinary Bladder 10.55 2.67 3.96 2.26 4.36 11.62 90.80 2.53 0.89 2.61 11.38 92.77 Kidney and Renal Pelvis 11.18 3.01 3.71 2.81 3.14 9.46 118.15 3.25 0.86 2.93 9.20 121.46 Brain and Other Nervous System 6.05 3.94 1.54 3.88 1.51 5.94 101.78 3.87 1.00 3.94 5.95 101.72 Hodgkin's Disease 2.03 0.37 5.43 0.39 6.56 2.45 82.78 0.38 1.03 0.38 2.47 82.26 Non-Hodgkin's Lymphomas 16.86 6.02 2.80 6.41 2.68 16.10 104.78 6.56 0.98 5.99 16.02 105.27 Multiple Myeloma 4.22 3.15 1.34 2.84 1.48 4.65 90.73 3.08 0.92 3.10 4.58 92.18 Leukemias 8.66 6.30 1.37 5.83 1.73 10.89 79.47 6.03 0.97 6.26 10.82 80.01 Sum of Rates for White Females 269.81 269.81 100.00 264.29 102.09

Sum of Rates for Whites 329.18 323.15 101.87 314.29 104.36

White Males

White Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality

SSR1: 8 of 21

Kentucky - 2004

Estimated Completeness Summary

Total Adjusted Incident Cases 21578 Total Incident Cases 21570

Race Proportional Completeness, Expected Adjusted for Reference Mortality 104.40 Incident Cases 20668

Final Completeness Estimates, Adjusted for Reference Mortality

%Unresolved Duplicates* 0.04 and Duplicate Records 104.36

* 0.00 indicates all duplicates are resolved.

104.40 4,092,257

Final Completeness Estimates Adjusted for Reference Mortality and Duplicate Records

104.36 3,770,445 104.90 321,812

Percent Complete Population

Percent Complete Population

Percent Complete Population

Interim Completeness Estimates Adjusted for Reference Mortality

SSR1: 9 of 21

Estimated Completeness of Case Ascertainment for Blacks Kentucky - 2003

Expected Initial Registry Adj Reg Expected Interim 2003 2002-2003 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 23.21 8.70 2.67 6.81 2.57 22.41 103.54 9.00 0.76 8.28 21.33 108.82 Esophagus 12.31 12.35 1.00 10.22 0.94 11.59 106.20 13.47 0.76 11.76 11.03 111.59 Stomach 9.42 10.75 0.88 11.86 1.44 15.44 61.02 8.80 1.35 11.49 16.51 57.05 Colon and Rectum 90.74 35.37 2.57 32.70 2.18 77.25 117.46 35.56 0.92 34.80 76.01 119.38 Liver 8.40 8.19 1.03 8.86 1.43 11.71 71.76 6.63 1.34 8.74 12.50 67.23 Pancreas 25.70 19.10 1.35 15.47 1.05 20.15 127.52 17.07 0.91 18.74 19.78 129.97 Lung and Bronchus 134.77 120.80 1.12 95.82 1.12 135.10 99.75 125.45 0.76 115.09 128.72 104.70 Melanoma of the Skin Prostate Urinary Bladder 17.69 8.64 2.05 5.34 3.85 33.23 53.23 7.81 0.68 8.10 31.13 56.82 Kidney and Renal Pelvis 20.28 5.89 3.45 6.09 3.37 19.86 102.12 5.53 1.10 6.00 20.26 100.11 Brain and Other Nervous System 11.00 1.47 7.46 3.20 1.52 2.25 489.44 2.11 1.52 1.63 2.48 443.52 Hodgkin's Disease 2.43 1.26 1.93 0.49 5.88 7.43 32.75 0.51 0.96 1.25 7.37 33.00 Non-Hodgkin's Lymphomas 17.67 7.11 2.49 6.54 2.85 20.27 87.20 8.83 0.74 6.74 19.22 91.97 Multiple Myeloma 16.24 9.27 1.75 8.45 1.58 14.65 110.88 9.15 0.92 9.13 14.43 112.58 Leukemias 6.96 8.57 0.81 8.76 1.47 12.60 55.26 9.48 0.92 8.44 12.41 56.12 Sum of Rates for Black Males 396.84 403.96 98.24 393.18 100.93

Expected Initial Registry Adj Reg Expected Interim 2003 2002-2003 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 4.58 1.57 2.91 1.71 3.55 5.59 81.96 1.84 0.93 1.55 5.51 83.12 Esophagus 3.82 2.00 1.91 2.98 1.16 2.32 164.71 2.20 1.36 2.14 2.48 153.73 Stomach 8.29 5.23 1.59 5.79 1.51 7.91 104.83 4.18 1.39 5.63 8.52 97.32 Colon and Rectum 68.76 33.89 2.03 22.93 2.38 80.50 85.41 30.67 0.75 32.18 76.44 89.96 Liver 2.74 1.53 1.79 3.04 1.15 1.75 155.95 2.50 1.22 1.59 1.83 149.48 Pancreas 13.76 11.40 1.21 12.42 1.11 12.70 108.33 11.76 1.06 11.53 12.85 107.11 Lung and Bronchus 86.88 58.58 1.48 39.83 1.38 80.66 107.71 60.63 0.66 54.56 75.13 115.64 Melanoma of the Skin Breast Cervix 16.83 5.93 2.84 4.87 2.07 12.25 137.34 5.95 0.82 5.71 11.81 142.53 Corpus and Uterus, NOS 24.48 7.36 3.33 7.10 2.78 20.44 119.81 6.61 1.08 7.47 20.74 118.03 Ovary 8.76 5.86 1.49 7.44 1.36 7.95 110.15 6.93 1.07 5.95 8.07 108.53 Urinary Bladder 12.13 4.27 2.84 2.81 2.75 11.74 103.30 3.41 0.83 4.12 11.33 107.04 Kidney and Renal Pelvis 10.76 3.35 3.21 2.77 3.54 11.87 90.70 2.98 0.93 3.30 11.69 92.04 Brain and Other Nervous System 5.97 3.30 1.81 2.16 1.62 5.36 111.45 3.97 0.54 3.00 4.87 122.66 Hodgkin's Disease 1.68 0.79 2.11 0.31 7.27 5.78 29.06 0.47 0.66 0.74 5.38 31.20 Non-Hodgkin's Lymphomas 7.61 4.69 1.62 4.28 2.86 13.40 56.79 4.03 1.06 4.75 13.56 56.11 Multiple Myeloma 11.69 5.99 1.95 6.26 1.52 9.09 128.57 5.18 1.21 6.24 9.47 123.45 Leukemias 10.94 7.31 1.50 5.32 1.54 11.26 97.18 5.98 0.89 7.15 11.01 99.37 Sum of Rates for Black Females 299.68 300.57 99.70 290.69 103.09

Sum of Rates for Blacks 347.20 351.14 98.88 340.82 102.03

Black Males

Black Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality

SSR1: 10 of 21

Estimated Completeness of Case Ascertainment for Whites Kentucky - 2003

Expected Initial Registry Adj Reg Expected Interim 2003 2002-2003 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 18.79 4.21 4.46 3.79 4.05 17.05 110.19 4.45 0.85 4.09 16.54 113.58 Esophagus 9.25 8.46 1.09 7.69 1.03 8.67 106.64 8.02 0.96 8.39 8.60 107.53 Stomach 7.79 5.04 1.55 5.21 1.96 9.89 78.77 4.84 1.08 5.12 10.04 77.57 Colon and Rectum 68.76 29.01 2.37 22.94 2.54 73.54 93.50 27.34 0.84 28.07 71.18 96.61 Liver 6.46 5.86 1.10 5.26 1.33 7.81 82.63 5.00 1.05 5.92 7.89 81.79 Pancreas 13.53 12.40 1.09 12.02 1.05 13.02 103.95 11.61 1.04 12.48 13.11 103.22 Lung and Bronchus 133.81 112.06 1.19 72.59 1.01 113.46 117.93 113.05 0.64 104.04 105.34 127.02 Melanoma of the Skin 24.36 5.18 4.70 4.34 6.21 32.18 75.69 5.08 0.85 5.03 31.24 77.96 Prostate Urinary Bladder 37.47 7.84 4.78 7.88 5.06 39.62 94.57 7.99 0.99 7.81 39.50 94.85 Kidney and Renal Pelvis 23.27 7.15 3.26 6.21 2.82 20.15 115.45 7.12 0.87 6.96 19.64 118.49 Brain and Other Nervous System 7.91 5.90 1.34 5.79 1.44 8.47 93.48 5.82 0.99 5.89 8.46 93.58 Hodgkin's Disease 2.80 0.84 3.31 0.58 5.63 4.76 58.77 0.80 0.72 0.80 4.50 62.24 Non-Hodgkin's Lymphomas 19.92 10.38 1.92 9.95 2.50 25.94 76.78 10.23 0.97 10.32 25.79 77.21 Multiple Myeloma 5.70 4.72 1.21 4.35 1.55 7.31 77.93 4.87 0.89 4.62 7.16 79.60 Leukemias 15.65 11.06 1.41 10.30 1.64 18.19 86.03 10.34 1.00 11.06 18.18 86.10 Sum of Rates for White Males 395.45 400.07 98.85 387.17 102.14

Expected Initial Registry Adj Reg Expected Interim 2003 2002-2003 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 5.87 1.32 4.46 1.49 4.13 5.44 107.96 1.61 0.93 1.30 5.36 109.52 Esophagus 1.83 1.27 1.43 1.65 1.18 1.50 121.49 1.36 1.21 1.33 1.57 116.48 Stomach 3.59 2.40 1.50 2.62 1.86 4.47 80.31 2.38 1.10 2.44 4.55 78.76 Colon and Rectum 51.50 19.31 2.67 15.92 2.70 52.21 98.63 18.91 0.84 18.69 50.56 101.86 Liver 1.86 2.06 0.90 1.89 1.25 2.58 72.38 2.22 0.85 2.00 2.50 74.58 Pancreas 10.22 9.35 1.09 9.00 1.08 10.14 100.80 8.80 1.02 9.39 10.19 100.35 Lung and Bronchus 75.78 56.65 1.34 42.15 1.20 67.91 111.58 55.51 0.76 53.92 64.64 117.22 Melanoma of the Skin 15.89 1.94 8.17 1.98 9.05 17.60 90.31 2.24 0.88 1.90 17.19 92.44 Breast Cervix 8.19 2.98 2.75 2.32 3.52 10.50 78.02 2.64 0.88 2.91 10.24 79.99 Corpus and Uterus, NOS 22.91 3.40 6.74 3.87 6.48 22.03 104.02 3.46 1.12 3.48 22.56 101.56 Ovary 11.36 9.48 1.20 9.23 1.55 14.71 77.27 8.98 1.03 9.53 14.79 76.85 Urinary Bladder 10.30 2.35 4.38 2.26 4.36 10.25 100.54 2.53 0.89 2.30 10.03 102.73 Kidney and Renal Pelvis 12.47 2.85 4.38 2.81 3.14 8.95 139.36 3.25 0.86 2.77 8.70 143.27 Brain and Other Nervous System 5.90 4.24 1.39 3.88 1.51 6.40 92.19 3.87 1.00 4.24 6.40 92.13 Hodgkin's Disease 2.36 0.41 5.74 0.39 6.56 2.70 87.54 0.38 1.03 0.41 2.72 87.00 Non-Hodgkin's Lymphomas 16.99 6.11 2.78 6.41 2.68 16.34 103.97 6.56 0.98 6.08 16.27 104.47 Multiple Myeloma 4.20 3.22 1.31 2.84 1.48 4.75 88.43 3.08 0.92 3.17 4.68 89.84 Leukemias 11.30 5.81 1.95 5.83 1.73 10.04 112.50 6.03 0.97 5.77 9.98 113.26 Sum of Rates for White Females 272.54 268.52 101.50 262.92 103.66

Sum of Rates for Whites 332.80 333.01 99.94 323.83 102.91

White Males

White Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality

SSR1: 11 of 21

Kentucky - 2003

Estimated Completeness Summary

Total Adjusted Incident Cases 21590 Total Incident Cases 21584

Race Proportional Completeness, Expected Adjusted for Reference Mortality 102.84 Incident Cases 20993

Final Completeness Estimates, Adjusted for Reference Mortality

%Unresolved Duplicates* 0.00 and Duplicate Records 102.82

* 0.00 indicates all duplicates are resolved.

102.84 4,069,206

Final Completeness Estimates Adjusted for Reference Mortality and Duplicate Records

102.91 3,750,452 102.03 318,754

Percent Complete Population

Percent Complete Population

Percent Complete Population

Interim Completeness Estimates Adjusted for Reference Mortality

SSR1: 12 of 21

Estimated Completeness of Case Ascertainment for Blacks Kentucky - 2002

Expected Initial Registry Adj Reg Expected Interim 2002 2001-2002 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 21.36 6.62 3.23 6.81 2.57 17.05 125.27 9.00 0.76 6.30 16.23 131.65 Esophagus 15.18 13.40 1.13 10.22 0.94 12.57 120.70 13.47 0.76 12.75 11.97 126.82 Stomach 13.63 11.89 1.15 11.86 1.44 17.09 79.78 8.80 1.35 12.72 18.27 74.59 Colon and Rectum 85.02 36.89 2.30 32.70 2.18 80.58 105.52 35.56 0.92 36.29 79.28 107.24 Liver 10.77 5.25 2.05 8.86 1.43 7.51 143.41 6.63 1.34 5.60 8.02 134.35 Pancreas 17.73 16.90 1.05 15.47 1.05 17.83 99.41 17.07 0.91 16.58 17.50 101.31 Lung and Bronchus 161.69 126.58 1.28 95.82 1.12 141.57 114.21 125.45 0.76 120.60 134.88 119.88 Melanoma of the Skin Prostate Urinary Bladder 24.62 6.62 3.72 5.34 3.85 25.46 96.73 7.81 0.68 6.20 23.85 103.25 Kidney and Renal Pelvis 20.33 5.35 3.80 6.09 3.37 18.07 112.54 5.53 1.10 5.46 18.43 110.33 Brain and Other Nervous System 7.25 1.78 4.08 3.20 1.52 2.71 267.65 2.11 1.52 1.96 2.99 242.53 Hodgkin's Disease 3.72 1.29 2.89 0.49 5.88 7.56 49.22 0.51 0.96 1.28 7.50 49.60 Non-Hodgkin's Lymphomas 17.87 12.58 1.42 6.54 2.85 35.86 49.85 8.83 0.74 11.93 34.00 52.58 Multiple Myeloma 13.74 9.43 1.46 8.45 1.58 14.89 92.27 9.15 0.92 9.28 14.66 93.69 Leukemias 14.29 10.77 1.33 8.76 1.47 15.85 90.21 9.48 0.92 10.61 15.60 91.61 Sum of Rates for Black Males 427.21 414.58 103.05 403.17 105.96

Expected Initial Registry Adj Reg Expected Interim 2002 2001-2002 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 3.40 2.35 1.45 1.71 3.55 8.34 40.69 1.84 0.93 2.32 8.23 41.26 Esophagus 1.49 2.77 0.54 2.98 1.16 3.21 46.49 2.20 1.36 2.97 3.44 43.39 Stomach 7.93 3.91 2.03 5.79 1.51 5.92 133.80 4.18 1.39 4.22 6.38 124.22 Colon and Rectum 70.47 33.97 2.07 22.93 2.38 80.69 87.34 30.67 0.75 32.25 76.61 91.99 Liver 3.46 1.10 3.16 3.04 1.15 1.26 274.58 2.50 1.22 1.14 1.32 263.18 Pancreas 11.19 11.61 0.96 12.42 1.11 12.94 86.43 11.76 1.06 11.75 13.09 85.46 Lung and Bronchus 68.41 56.55 1.21 39.83 1.38 77.86 87.86 60.63 0.66 52.67 72.52 94.33 Melanoma of the Skin Breast Cervix 11.48 4.89 2.35 4.87 2.07 10.12 113.48 5.95 0.82 4.72 9.75 117.76 Corpus and Uterus, NOS 19.67 4.90 4.02 7.10 2.78 13.60 144.65 6.61 1.08 4.97 13.80 142.49 Ovary 12.68 5.67 2.24 7.44 1.36 7.68 165.07 6.93 1.07 5.75 7.80 162.64 Urinary Bladder 8.36 3.45 2.42 2.81 2.75 9.48 88.24 3.41 0.83 3.33 9.14 91.44 Kidney and Renal Pelvis 16.65 4.48 3.72 2.77 3.54 15.86 104.98 2.98 0.93 4.41 15.62 106.53 Brain and Other Nervous System 3.35 4.04 0.83 2.16 1.62 6.56 51.03 3.97 0.54 3.67 5.96 56.16 Hodgkin's Disease 1.13 0.80 1.42 0.31 7.27 5.83 19.47 0.47 0.66 0.75 5.43 20.90 Non-Hodgkin's Lymphomas 10.55 3.69 2.86 4.28 2.86 10.54 100.06 4.03 1.06 3.73 10.67 98.86 Multiple Myeloma 9.52 5.74 1.66 6.26 1.52 8.71 109.33 5.18 1.21 5.98 9.07 104.98 Leukemias 8.30 5.10 1.63 5.32 1.54 7.85 105.66 5.98 0.89 4.98 7.68 108.05 Sum of Rates for Black Females 268.04 286.46 93.57 276.52 96.93

Sum of Rates for Blacks 345.86 349.10 99.07 338.44 101.35

Black Males

Black Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality

SSR1: 13 of 21

Estimated Completeness of Case Ascertainment for Whites Kentucky - 2002

Expected Initial Registry Adj Reg Expected Interim 2002 2001-2002 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 19.43 4.64 4.19 3.79 4.05 18.80 103.38 4.45 0.85 4.50 18.23 106.56 Esophagus 7.96 8.45 0.94 7.69 1.03 8.66 91.84 8.02 0.96 8.38 8.59 92.61 Stomach 9.26 5.17 1.79 5.21 1.96 10.14 91.28 4.84 1.08 5.25 10.30 89.88 Colon and Rectum 69.52 27.93 2.49 22.94 2.54 70.82 98.16 27.34 0.84 27.03 68.54 101.43 Liver 5.54 5.24 1.06 5.26 1.33 6.99 79.21 5.00 1.05 5.29 7.06 78.41 Pancreas 12.54 11.21 1.12 12.02 1.05 11.77 106.61 11.61 1.04 11.29 11.85 105.86 Lung and Bronchus 138.44 116.94 1.18 72.59 1.01 118.40 116.93 113.05 0.64 108.57 109.92 125.94 Melanoma of the Skin 23.49 5.47 4.29 4.34 6.21 33.99 69.13 5.08 0.85 5.31 33.00 71.20 Prostate Urinary Bladder 39.90 7.58 5.26 7.88 5.06 38.32 104.12 7.99 0.99 7.56 38.21 104.43 Kidney and Renal Pelvis 20.75 7.16 2.90 6.21 2.82 20.18 102.82 7.12 0.87 6.97 19.66 105.52 Brain and Other Nervous System 7.31 6.37 1.15 5.79 1.44 9.15 79.93 5.82 0.99 6.37 9.14 80.01 Hodgkin's Disease 3.33 0.93 3.56 0.58 5.63 5.27 63.25 0.80 0.72 0.88 4.97 66.98 Non-Hodgkin's Lymphomas 22.53 10.04 2.24 9.95 2.50 25.10 89.78 10.23 0.97 9.98 24.96 90.28 Multiple Myeloma 7.68 5.14 1.50 4.35 1.55 7.96 96.50 4.87 0.89 5.03 7.79 98.57 Leukemias 17.49 11.39 1.54 10.30 1.64 18.72 93.39 10.34 1.00 11.38 18.71 93.46 Sum of Rates for White Males 405.18 404.27 100.23 390.95 103.64

Expected Initial Registry Adj Reg Expected Interim 2002 2001-2002 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 5.46 1.52 3.60 1.49 4.13 6.26 87.19 1.61 0.93 1.49 6.17 88.45 Esophagus 1.44 1.36 1.06 1.65 1.18 1.61 89.41 1.36 1.21 1.42 1.68 85.73 Stomach 3.46 2.22 1.56 2.62 1.86 4.14 83.51 2.38 1.10 2.26 4.22 81.90 Colon and Rectum 51.29 19.39 2.65 15.92 2.70 52.43 97.81 18.91 0.84 18.77 50.77 101.01 Liver 1.95 2.27 0.86 1.89 1.25 2.83 69.02 2.22 0.85 2.20 2.75 71.11 Pancreas 9.49 9.01 1.05 9.00 1.08 9.77 97.16 8.80 1.02 9.05 9.81 96.73 Lung and Bronchus 75.58 55.98 1.35 42.15 1.20 67.12 112.61 55.51 0.76 53.28 63.88 118.31 Melanoma of the Skin 16.11 2.35 6.85 1.98 9.05 21.29 75.65 2.24 0.88 2.30 20.80 77.44 Breast Cervix 10.23 2.55 4.01 2.32 3.52 8.98 113.92 2.64 0.88 2.49 8.75 116.80 Corpus and Uterus, NOS 22.16 3.21 6.91 3.87 6.48 20.77 106.69 3.46 1.12 3.28 21.27 104.17 Ovary 12.99 9.45 1.37 9.23 1.55 14.66 88.60 8.98 1.03 9.50 14.74 88.12 Urinary Bladder 9.32 2.33 4.00 2.26 4.36 10.16 91.74 2.53 0.89 2.28 9.95 93.74 Kidney and Renal Pelvis 10.20 3.43 2.97 2.81 3.14 10.77 94.64 3.25 0.86 3.33 10.48 97.29 Brain and Other Nervous System 6.42 3.80 1.69 3.88 1.51 5.74 111.95 3.87 1.00 3.80 5.74 111.89 Hodgkin's Disease 3.20 0.39 8.16 0.39 6.56 2.57 124.50 0.38 1.03 0.40 2.59 123.72 Non-Hodgkin's Lymphomas 17.06 6.59 2.59 6.41 2.68 17.64 96.70 6.56 0.98 6.56 17.56 97.16 Multiple Myeloma 4.48 3.09 1.45 2.84 1.48 4.56 98.12 3.08 0.92 3.04 4.49 99.68 Leukemias 8.58 5.62 1.53 5.83 1.73 9.72 88.27 6.03 0.97 5.58 9.65 88.86 Sum of Rates for White Females 269.41 271.02 99.40 265.31 101.54

Sum of Rates for Whites 335.91 336.28 99.89 326.85 102.57

White Males

White Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality

SSR1: 14 of 21

Kentucky - 2002

Estimated Completeness Summary

Total Adjusted Incident Cases 21599 Total Incident Cases 21593

Race Proportional Completeness, Expected Adjusted for Reference Mortality 102.48 Incident Cases 21077

Final Completeness Estimates, Adjusted for Reference Mortality

%Unresolved Duplicates* 0.03 and Duplicate Records 102.45

* 0.00 indicates all duplicates are resolved.

102.48 4,042,899

Final Completeness Estimates Adjusted for Reference Mortality and Duplicate Records

102.57 3,727,351 101.35 315,548

Percent Complete Population

Percent Complete Population

Percent Complete Population

Interim Completeness Estimates Adjusted for Reference Mortality

SSR1: 15 of 21

Estimated Completeness of Case Ascertainment for Blacks Kentucky - 2001

Expected Initial Registry Adj Reg Expected Interim 2001 2000-2001 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 16.17 10.36 1.56 6.81 2.57 26.67 60.62 9.00 0.76 9.86 25.38 63.71 Esophagus 18.22 14.30 1.27 10.22 0.94 13.42 135.79 13.47 0.76 13.61 12.77 142.67 Stomach 19.47 9.52 2.04 11.86 1.44 13.68 142.30 8.80 1.35 10.18 14.63 133.04 Colon and Rectum 80.61 39.26 2.05 32.70 2.18 85.75 94.00 35.56 0.92 38.63 84.37 95.54 Liver 6.81 3.78 1.80 8.86 1.43 5.40 126.05 6.63 1.34 4.03 5.77 118.08 Pancreas 14.29 16.72 0.85 15.47 1.05 17.64 81.00 17.07 0.91 16.40 17.31 82.55 Lung and Bronchus 129.99 135.56 0.96 95.82 1.12 151.60 85.74 125.45 0.76 129.15 144.44 90.00 Melanoma of the Skin Prostate Urinary Bladder 23.67 8.43 2.81 5.34 3.85 32.42 73.01 7.81 0.68 7.90 30.37 77.93 Kidney and Renal Pelvis 19.70 7.29 2.70 6.09 3.37 24.60 80.08 5.53 1.10 7.44 25.09 78.51 Brain and Other Nervous System 1.19 2.18 0.55 3.20 1.52 3.32 35.81 2.11 1.52 2.41 3.67 32.45 Hodgkin's Disease 3.09 0.00 0.00 0.49 5.88 0.00 0.00 0.51 0.96 0.00 0.00 0.00 Non-Hodgkin's Lymphomas 21.33 13.34 1.60 6.54 2.85 38.03 56.09 8.83 0.74 12.65 36.06 59.16 Multiple Myeloma 16.10 9.06 1.78 8.45 1.58 14.30 112.54 9.15 0.92 8.92 14.09 114.28 Leukemias 17.75 10.85 1.64 8.76 1.47 15.97 111.17 9.48 0.92 10.69 15.73 112.90 Sum of Rates for Black Males 388.38 442.81 87.71 429.66 90.39

Expected Initial Registry Adj Reg Expected Interim 2001 2000-2001 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 5.60 2.73 2.05 1.71 3.55 9.69 57.80 1.84 0.93 2.69 9.55 58.63 Esophagus 2.31 2.38 0.97 2.98 1.16 2.76 83.62 2.20 1.36 2.55 2.96 78.04 Stomach 7.40 3.36 2.20 5.79 1.51 5.09 145.45 4.18 1.39 3.62 5.48 135.04 Colon and Rectum 65.27 30.69 2.13 22.93 2.38 72.90 89.54 30.67 0.75 29.14 69.21 94.30 Liver 0.79 2.16 0.36 3.04 1.15 2.49 31.55 2.50 1.22 2.26 2.60 30.24 Pancreas 9.19 10.55 0.87 12.42 1.11 11.76 78.19 11.76 1.06 10.67 11.89 77.31 Lung and Bronchus 77.16 60.97 1.27 39.83 1.38 83.96 91.90 60.63 0.66 56.79 78.20 98.67 Melanoma of the Skin Breast Cervix 15.05 6.35 2.37 4.87 2.07 13.12 114.68 5.95 0.82 6.12 12.65 119.01 Corpus and Uterus, NOS 15.04 8.23 1.83 7.10 2.78 22.84 65.87 6.61 1.08 8.35 23.18 64.89 Ovary 7.67 8.21 0.93 7.44 1.36 11.13 68.98 6.93 1.07 8.33 11.29 67.96 Urinary Bladder 6.51 2.40 2.71 2.81 2.75 6.60 98.61 3.41 0.83 2.32 6.37 102.19 Kidney and Renal Pelvis 12.01 3.37 3.56 2.77 3.54 11.94 100.66 2.98 0.93 3.32 11.76 102.15 Brain and Other Nervous System 6.98 3.94 1.77 2.16 1.62 6.40 109.15 3.97 0.54 3.58 5.81 120.12 Hodgkin's Disease 1.25 0.42 3.01 0.31 7.27 3.03 41.43 0.47 0.66 0.39 2.82 44.47 Non-Hodgkin's Lymphomas 10.10 3.44 2.93 4.28 2.86 9.84 102.66 4.03 1.06 3.48 9.96 101.43 Multiple Myeloma 6.11 4.75 1.28 6.26 1.52 7.21 84.65 5.18 1.21 4.95 7.51 81.28 Leukemias 11.70 4.97 2.35 5.32 1.54 7.66 152.78 5.98 0.89 4.86 7.49 156.22 Sum of Rates for Black Females 260.15 288.40 90.21 278.74 93.33

Sum of Rates for Blacks 322.83 363.87 88.72 352.51 91.89

Black Males

Black Females Adjusted for Mortality

Kentucky SEER (11 Regs) and US Mortality

Age-Adjusted Rates (2000 US) Age-Adjusted Rates (2000 US) Kentucky SEER (11 Regs) and US Mortality Initial Results Mortality Adjustment Terms

Initial Results Mortality Adjustment Terms Adjusted for Mortality

SSR1: 16 of 21

Estimated Completeness of Case Ascertainment for Whites Kentucky - 2001

Expected Initial Registry Adj Reg Expected Interim 2001 2000-2001 Inc/Mort 2000-2004 Inc/Mort Incidence Percent 2000-2004 Adjust. 2000 Incidence Percent

Cancer Site Incidence Mortality Ratio Mortality Ratio Rate Complete Mort Rate Term Mort Rate Rate Complete Oral Cavity and Pharynx 16.87 5.05 3.34 3.79 4.05 20.44 82.53 4.45 0.85 4.90 19.83 85.07 Esophagus 8.18 7.86 1.04 7.69 1.03 8.06 101.47 8.02 0.96 7.80 7.99 102.31 Stomach 9.06 4.66 1.94 5.21 1.96 9.15 99.05 4.84 1.08 4.73 9.29 97.53 Colon and Rectum 77.15 27.97 2.76 22.94 2.54 70.91 108.81 27.34 0.84 27.07 68.62 112.43 Liver 4.76 4.44 1.07 5.26 1.33 5.93 80.26 5.00 1.05 4.49 5.99 79.45 Pancreas 11.92 11.03 1.08 12.02 1.05 11.58 102.90 11.61 1.04 11.11 11.67 102.18 Lung and Bronchus 145.64 117.80 1.24 72.59 1.01 119.27 122.11 113.05 0.64 109.36 110.73 131.53 Melanoma of the Skin 27.83 5.04 5.52 4.34 6.21 31.30 88.92 5.08 0.85 4.89 30.39 91.58 Prostate Urinary Bladder 38.68 8.24 4.69 7.88 5.06 41.68 92.79 7.99 0.99 8.22 41.56 93.07 Kidney and Renal Pelvis 21.83 6.96 3.14 6.21 2.82 19.62 111.28 7.12 0.87 6.78 19.12 114.21 Brain and Other Nervous System 7.27 6.39 1.14 5.79 1.44 9.18 79.19 5.82 0.99 6.39 9.17 79.27 Hodgkin's Disease 4.10 0.72 5.67 0.58 5.63 4.07 100.58 0.80 0.72 0.68 3.85 106.52 Non-Hodgkin's Lymphomas 19.96 10.64 1.88 9.95 2.50 26.61 75.03 10.23 0.97 10.58 26.46 75.46 Multiple Myeloma 6.35 5.30 1.20 4.35 1.55 8.21 77.38 4.87 0.89 5.19 8.04 79.04 Leukemias 16.51 10.25 1.61 10.30 1.64 16.86 97.93 10.34 1.00 10.25 16.84…