MSDS-0264E.pdf

Millipore - NX0409

The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

Version 8.0 Revision Date 01/06/2021

Print Date 01/28/2022

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name : Nitric Acid GR ACS

Product Number : NX0409

Brand : Millipore

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Reagent for analysis

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Inc.

3050 SPRUCE ST

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Oxidizing liquids (Category 3), H272

Corrosive to Metals (Category 1), H290

Acute toxicity, Inhalation (Category 3), H331

Skin corrosion (Category 1A), H314

Serious eye damage (Category 1), H318

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 GHS Label elements, including precautionary statements

Pictogram

Signal word Danger

Hazard statement(s)

H272 May intensify fire; oxidizer.

H290 May be corrosive to metals.

H314 Causes severe skin burns and eye damage.

H331 Toxic if inhaled.

Precautionary statement(s)

P210 Keep away from heat.

P220 Keep/Store away from clothing/ combustible materials.

P221 Take any precaution to avoid mixing with combustibles.

P234 Keep only in original container.

P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.

P264 Wash skin thoroughly after handling.

P271 Use only outdoors or in a well-ventilated area.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.

P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor.

P305 + P351 + P338 +

P310

IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.

P363 Wash contaminated clothing before reuse.

P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.

P390 Absorb spillage to prevent material damage.

P403 + P233 Store in a well-ventilated place. Keep container tightly closed.

P405 Store locked up.

P406 Store in corrosive resistant container with a resistant inner liner.

P501 Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none

SECTION 3: Composition/information on ingredients

3.2 Mixtures

Component Classification Concentration nitric acid

CAS-No.

EC-No.

Index-No.

Registration number

7697-37-2

231-714-2

007-004-00-1

01-2119487297-23-

XXXX

Ox. Liq. 2; Met. Corr. 1;

Acute Tox. 3; Skin Corr.

1A; Eye Dam. 1; H272, H290, H331, H314, H318

Concentration limits:

>= 1 %: Met. Corr. 1, H290; <= 70 %: Acute

Tox. 3, H331; > 70 %:

Acute Tox. 1, H330; >=

20 %: Skin Corr. 1A, H314; 5 - < 20 %: Skin

Corr. 1B, H314; 65 - < 99

%: Ox. Liq. 3, H272; >=

99 %: Ox. Liq. 2, H272;

>= 65 - < 70

>= 3 %: Eye Dam. 1, H318; 1 - < 3 %: Eye

Irrit. 2, H319; 1 - < 5 %:

Skin Irrit. 2, H315;

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

First aider needs to protect himself.

If inhaled

After inhalation: fresh air. Call in physician.If breathing stops: immediately apply artificial respiration, if necessary also oxygen.

In case of skin contact

In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.

In case of eye contact

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.

Remove contact lenses.

If swallowed

After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Call a physician immediately. Do not attempt to neutralise.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section

2.2) and/or in section 11

4.3 Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

5.2 Special hazards arising from the substance or mixture

Not combustible.

Has a fire-promoting effect due to release of oxygen.

Ambient fire may liberate hazardous vapours.

Fire may cause evolution of:

nitrous gases, nitrogen oxides

5.3 Advice for firefighters

Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.

5.4 Further information

Suppress (knock down) gases/vapors/mists with a water spray jet. Cool closed containers exposed to fire with water spray. Prevent fire extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Advice for non-emergency personnel: Avoid substance contact. Do not breathe vapors, aerosols. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.

For personal protection see section 8.

6.2 Environmental precautions

Do not empty into drains.

6.3 Methods and materials for containment and cleaning up

Cover drains. Collect, bind, and pump off spills.Observe possible material restrictions (see sections 7 and 10).Take up with liquid-absorbent and neutralising material (e.g.

Chemizorb® H⁺, Merck Art. No. 101595). Dispose of properly. Clean up affected area.

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Advice on safe handling

Observe label precautions.Advice on safe handling

Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.

Hygiene measures

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Storage conditions

No metal or light-weight-metal containers.

Tightly closed. Do not store near combustible materials. Keep locked up or in an area accessible only to qualified or authorized persons.

Store at room temperature.

Storage class (TRGS 510): 5.1B: Oxidizing hazardous materials

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

Component CAS-No. Value Control parameters

Basis nitric acid

7697-37-2

TWA 2 ppm

USA. ACGIH Threshold Limit

Values (TLV) STEL 4 ppm

USA. ACGIH Threshold Limit

Values (TLV) TWA 2 ppm

5 mg/m³

USA. NIOSH Recommended

Exposure Limits ST 4 ppm

10 mg/m³

USA. NIOSH Recommended

Exposure Limits TWA 2 ppm

5 mg/m³

USA. Occupational Exposure

Limits (OSHA) - Table Z-1

Limits for Air Contaminants PEL 2 ppm

5 mg/m³

California permissible exposure limits for chemical contaminants (Title 8, Article

107) STEL 4 ppm

10 mg/m³

California permissible exposure limits for chemical contaminants (Title 8, Article

107)

8.2 Exposure controls

Appropriate engineering controls

Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.

Personal protective equipment

Eye/face protection

Tightly fitting safety goggles

Skin protection

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Full contact

Material: Viton®

Minimum layer thickness: 0.7 mm

Break through time: > 480 min

Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)

This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN374 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Splash contact

Material: Latex gloves

Minimum layer thickness: 0.6 mm

Break through time: > 120 min

Material tested:Lapren® (KCL 706 / Aldrich Z677558, Size M)

Body Protection acid-resistant protective clothing

Respiratory protection required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.

Control of environmental exposure

Do not empty into drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid

Color: colorless

b) Odor stinging

c) Odor Threshold 0.27 ppm - (anhydrous substance)

d) pH < 1 at 20 °C (68 °F)

e) Melting point/freezing point

Melting point: ca.-32 °C (ca.-26 °F)

f) Initial boiling point and boiling range

121 °C 250 °F at 1,013 hPa

g) Flash point ()Not applicable

h) Evaporation rate No data available

i) Flammability (solid, gas)

No data available

j) Upper/lower flammability or explosive limits

No data available

k) Vapor pressure ca.9.4 hPa at 20 °C (68 °F)

l) Vapor density No data available

m) Relative density 1.39 g/cm³ at 20 °C (68 °F)

n) Water solubility soluble

o) Partition coefficient:

n-octanol/water

No data available

p) Autoignition temperature

No data available

q) Decomposition temperature

Distillable in an undecomposed state at normal pressure.

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties The substance or mixture is classified as oxidizing with the category 3.

9.2 Other safety information

SECTION 10: Stability and reactivity

10.1 Reactivity

strong oxidising agent

10.2 Chemical stability

No data available

10.3 Possibility of hazardous reactions

Risk of explosion with:

Acetone acetonitrile acetylidene

Alcohols

Dithallium trioxide antimony hydride arsenic hydride

Organic Substances

Benzene phosphides anilines

Amines

Halogenated hydrocarbon

Diethyl ether dimethyl ether hydrazines

Nitro compounds

Sulfides

Dioxane acetic acid

Acetic anhydride ethanol

Ethylene glycol

Fluorine

Formaldehyde

Rubber oils

Hydrazine hydrate

Hydrocarbons

Copper lithium silicide organic solvents

Manganese

Cyanides

Powdered metals

Methanol petrol

Sodium hydrosulfide phosphorus hydrogen anhydrides

Reducing agents sulphur dioxide

Boranes thiocyanates

Titanium

Toluene

Impurities

Nitric acid hydrogen peroxide

Tin sugars xylene dichloromethane carbon/soot potassium chlorate with

Organic Substances mercury(II) nitrate with ethanol

Organic Substances with sulfuric acid

Nitrobenzene with sulfuric acid potassium permanganate with

Alcohols glycerol with sulfuric acid

Risk of ignition or formation of inflammable gases or vapours with:

Amines

Ammonia combustible substances

Aldehydes furfuryl alcohol hydrogen iodide

Potassium

Lithium

Magnesium phosphides sodium hydrides phosphorus pyridine hydrogen sulphide

3-BROMO-5-CHLORO-4-HYDROXYBENZALDEHYDE

Violent reactions possible with:

Nitriles antimony arsenic

Boron ferric oxide alkalines sodium hypochlorite formic acid halogen-halogen compounds

Germanium glycerol nitrides

Sodium hydroxide solution

Sodium hydroxide sulfuric acid selenium

Bismuth chlorates

10.4 Conditions to avoid

10.5 Incompatible materials

Cellulose, MetalsContact with metals may lead to the formation of nitrous gases and hydrogen.

10.6 Hazardous decomposition products

in the event of fire: See section 5.

In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Mixture

Acute toxicity

Symptoms: If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.

Acute toxicity estimate Inhalation - 4 h - 3.85 mg/l

(Calculation method)

Dermal: No data available

No data available

Skin corrosion/irritation

Serious eye damage/eye irritation

Mixture causes serious eye damage. Risk of blindness!

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

No data available

Carcinogenicity

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

Specific target organ toxicity - single exposure

Acute oral toxicity - If ingested, severe burns of the mouth and throat, as well as a danger of perforation of the esophagus and the stomach.

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

11.2 Additional Information

Not available

Irritation and corrosion

Cough

Shortness of breath

Bloody vomiting death

Risk of blindness!

strong pain (risk of perforation!)

tissue damage

The following applies to nitrites/nitrates in general: methaemoglobinaemia after the uptake of large quantities.

Other dangerous properties can not be excluded.

This substance should be handled with particular care.

Components

Acute toxicity

No data available

Acute toxicity estimate Inhalation - 4 h - 2.5 mg/l

(Expert judgment)

Dermal: No data available

No data available

Skin corrosion/irritation

Skin - Rabbit

Result: Causes severe burns.

Remarks:

(IUCLID)

Causes poorly healing wounds.

Serious eye damage/eye irritation

Eyes - Rabbit

Result: Causes burns.

Remarks:

(IUCLID)

Causes serious eye damage.

Respiratory or skin sensitization

Germ cell mutagenicity

Ames test

Salmonella typhimurium

Result: negative

Carcinogenicity

Reproductive toxicity

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

SECTION 12: Ecological information

12.1 Toxicity

Mixture

No data available

12.2 Persistence and degradability

The methods for determining the biological degradability are not applicable to inorganic substances.

No data available

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Other adverse effects

Biological effects:

Harmful effect due to pH shift. Forms corrosive mixtures with water even if diluted. Does not cause biological oxygen deficit. Hazard for drinking water supplies.

Discharge into the environment must be avoided.

No data available

Components

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product

Waste material must be disposed of in accordance with the national and loc No mixing with other waste. Handle uncleaned containers like the product See www.retrologistik.com for processes regarding the return of chemicals and containers, or contact us there if you have further questions.

SECTION 14: Transport information

DOT (US)

UN number: 2031 Class: 8 (5.1) Packing group: II

Proper shipping name: Nitric acid

Reportable Quantity (RQ): 1538 lbs

Poison Inhalation Hazard: No

IMDG

UN number: 2031 Class: 8 (5.1) Packing group: II EMS-No: F-A, S-Q

Proper shipping name: NITRIC ACID

IATA

UN number: 2031 Class: 8 (5.1) Packing group: II

Proper shipping name: Nitric acid

IATA Passenger: Not permitted for transport

SECTION 15: Regulatory information

SARA 302 Components

CAS-No.

Revision Date

2007-07-01

SARA 313 Components

The following components are subject to reporting levels established by SARA Title III, Section 313:

CAS-No.

Revision Date

2007-07-01

Massachusetts Right To Know Components

No components are subject to the Massachusetts Right to Know Act.

SECTION 16: Other information

Further information

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.

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Version: 8.0 Revision Date: 01/06/2021 Print Date: 01/28/2022