MSDS-0163A.pdf

SAFETY DATA SHEET

Creation Date 24-Nov-2010 Revision Date 14-Feb-2020 Revision Number 3

1. Identification Product Name Chromium(VI) oxide

Cat No. : 36468

CAS-No 1333-82-0 Synonyms Chromium trioxide; Chromic acid; Chromic anhydride

Recommended Use Laboratory chemicals.

Uses advised against .

Details of the supplier of the safety data sheet

Emergency Telephone Number During normal business hours (Monday-Friday, 8am-7pm EST), call (800) 343-0660.

After normal business hours, call Carechem 24 at (866) 928-0789.

2. Hazard(s) identification Classification This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Company Alfa Aesar Thermo Fisher Scientific Chemicals, Inc.

30 Bond Street Ward Hill, MA 01835-8099 Tel: 800-343-0660 Fax: 800-322-4757 Email: tech@alfa.com www.alfa.com

Acute oral toxicity Category 3 Acute dermal toxicity Category 2 Acute Inhalation Toxicity - Dusts and Mists Category 2 Skin Corrosion/Irritation Category 1 A Serious Eye Damage/Eye Irritation Category 1 Respiratory Sensitization Category 1 Skin Sensitization Category 1 Germ Cell Mutagenicity Category 1B Carcinogenicity Category 1A Reproductive Toxicity Category 2 Specific target organ toxicity (single exposure) Category 3 Target Organs - Respiratory system.

Specific target organ toxicity - (repeated exposure) Category 1 Target Organs - Liver, Kidney, Blood.

Oxidizing solids Category 1

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Chromium(VI) oxide Revision Date 14-Feb-2020

Label Elements

Signal Word Danger

Hazard Statements May cause fire or explosion; strong oxidizer Toxic if swallowed Causes severe skin burns and eye damage May cause respiratory irritation May cause an allergic skin reaction May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause genetic defects May cause cancer Suspected of damaging fertility Causes damage to organs through prolonged or repeated exposure Fatal in contact with skin or if inhaled

Precautionary Statements Prevention Obtain special instructions before use Do not handle until all safety precautions have been read and understood Use personal protective equipment as required Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product Do not get in eyes, on skin, or on clothing Do not breathe dust/fume/gas/mist/vapors/spray Use only outdoors or in a well-ventilated area Wear respiratory protection In case of inadequate ventilation wear respiratory protection Contaminated work clothing should not be allowed out of the workplace Wear protective gloves Keep away from heat/sparks/open flames/hot surfaces. - No smoking Keep/Store away from clothing/ other combustible materials Take any precaution to avoid mixing with combustibles Wear fire/flame resistant/retardant clothing Response Immediately call a POISON CENTER or doctor/physician Inhalation IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing Skin IF ON SKIN: Gently wash with plenty of soap and water Wash contaminated clothing before reuse If skin irritation or rash occurs: Get medical advice/attention IF ON CLOTHING: Rinse immediately contaminated clothing and skin with plenty of water before removing clothes Rinse skin with water/shower Eyes IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing Ingestion Rinse mouth Do NOT induce vomiting

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Fire

In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion In case of fire: Use CO2, dry chemical, or foam for extinction Storage Store locked up Store in a well-ventilated place. Keep container tightly closed Disposal Dispose of contents/container to an approved waste disposal plant Hazards not otherwise classified (HNOC) Very toxic to aquatic life with long lasting effects WARNING. Cancer and Reproductive Harm - https://www.p65warnings.ca.gov/.

3. Composition/Information on Ingredients

Component CAS-No Weight % Chromium trioxide (CrO3) 1333-82-0 >95

4. First-aid measures

General Advice Show this safety data sheet to the doctor in attendance. Immediate medical attention is required.

Eye Contact In the case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical attention is required.

Inhalation Remove to fresh air. If not breathing, give artificial respiration. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Immediate medical attention is required.

Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and effects

Causes burns by all exposure routes. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause allergic skin reaction. Ingestion causes severe swelling, severe damage to the delicate tissue and danger of perforation: Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing: Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should be investigated

Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Substance is nonflammable; use agent most appropriate to extinguish surrounding fire. CO 2, dry chemical, dry sand, alcohol-resistant foam.

Unsuitable Extinguishing Media No information available

Flash Point No information available Method - No information available

Autoignition Temperature Explosion Limits

Upper No data available

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Lower No data available Oxidizing Properties Oxidizer

Sensitivity to Mechanical Impact No information available Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical The product causes burns of eyes, skin and mucous membranes. Oxidizer: Contact with combustible/organic material may cause fire. May ignite combustibles (wood paper, oil, clothing, etc.). Do not allow run-off from fire-fighting to enter drains or water courses.

Hazardous Combustion Products Toxic fumes.

Protective Equipment and Precautions for Firefighters As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA

6. Accidental release measures Personal Precautions Use personal protective equipment as required. Evacuate personnel to safe areas. Ensure adequate ventilation. Keep people away from and upwind of spill/leak. Avoid dust formation.

Environmental Precautions Do not flush into surface water or sanitary sewer system. Do not allow material to contaminate ground water system. Prevent product from entering drains. Local authorities should be advised if significant spillages cannot be contained.

Methods for Containment and Clean Up

Sweep up and shovel into suitable containers for disposal. Avoid dust formation. Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. Sweep up and shovel into suitable containers for disposal.

7. Handling and storage Handling Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on clothing. Use only under a chemical fume hood. Do not ingest. If swallowed then seek immediate medical assistance. Do not breathe (dust, vapor, mist, gas). Avoid dust formation. Keep away from clothing and other combustible materials.

Storage Keep in a dry, cool and well-ventilated place. Refer product specification and/or product label for specific storage temperature requirement. Keep container tightly closed. Do not store near combustible materials. Corrosives area. Store under an inert atmosphere.

Protect from moisture.

8. Exposure controls / personal protection Exposure Guidelines

Health

Flammability

Instability

Physical hazards

OX

Component ACGIH TLV OSHA PEL NIOSH IDLH Mexico OEL (TWA) Chromium trioxide (CrO3) TWA: 0.0002 mg/m3

STEL: 0.0005 mg/m3

Skin

(Vacated) Ceiling: 0.1 mg/m3

Ceiling: 0.1 mg/m3

IDLH: 15 mg/m3

TWA: 0.0002 mg/m3

TWA: 0.05 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists OSHA - Occupational Safety and Health Administration NIOSH IDLH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures

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Use only under a chemical fume hood. Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation

9. Physical and chemical properties Physical State Solid Appearance Reddish violet Odor Odorless Odor Threshold No information available pH 1 50g/l aq.sol Melting Point/Range 196 °C / 384.8 °F Boiling Point/Range No information available Flash Point No information available Evaporation Rate Not applicable Flammability (solid,gas) No information available Flammability or explosive limits

Upper No data available Lower No data available

Vapor Pressure No information available Vapor Density Not applicable Specific Gravity No information available Solubility Soluble in water Partition coefficient; n-octanol/water No data available Autoignition Temperature Decomposition Temperature 198 °C Viscosity Not applicable Molecular Formula Cr O3 Molecular Weight 99.99

10. Stability and reactivity

Reactive Hazard Yes

Stability Oxidizer: Contact with combustible/organic material may cause fire. Hygroscopic.

Conditions to Avoid Excess heat. Incompatible products. Exposure to moist air or water. Combustible material.

Incompatible Materials Bases, Alcohols, Amines, Ammonia, Hydrocarbons, Ketones, Acetone, Acid anhydrides, Metals, Reducing Agent, Finely powdered metals, Strong reducing agents, Combustible material

Hazardous Decomposition Products Toxic fumes

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

location.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard

EN166.

Skin and body protection Wear appropriate protective gloves and clothing to prevent skin exposure.

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Hygiene Measures

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Handle in accordance with good industrial hygiene and safety practice.

11. Toxicological information Acute Toxicity

Product Information Component Information

Component LD50 Oral LD50 Dermal LC50 Inhalation Chromium trioxide (CrO3) LD50 = 80 mg/kg ( Rat ) LD50 = 57 mg/kg ( Rabbit ) LC50 = 217 mg/m3 ( Rat ) 4 h

Toxicologically Synergistic Products

No information available

Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Causes severe burns by all exposure routes

Sensitization May cause sensitization by skin contact

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS-No IARC NTP ACGIH OSHA Mexico Chromium trioxide

(CrO3) 1333-82-0 Group 1 Known A1 X A1

IARC (International Agency for Research on Cancer) IARC (International Agency for Research on Cancer) Group 1 - Carcinogenic to Humans Group 2A - Probably Carcinogenic to Humans Group 2B - Possibly Carcinogenic to Humans

NTP: (National Toxicity Program) NTP: (National Toxicity Program) Known - Known Carcinogen Reasonably Anticipated - Reasonably Anticipated to be a Human Carcinogen

ACGIH: (American Conference of Governmental Industrial Hygienists)

A1 - Known Human Carcinogen A2 - Suspected Human Carcinogen A3 - Animal Carcinogen ACGIH: (American Conference of Governmental Industrial Hygienists)

Mexico - Occupational Exposure Limits - Carcinogens Mexico - Occupational Exposure Limits - Carcinogens A1 - Confirmed Human Carcinogen A2 - Suspected Human Carcinogen A3 - Confirmed Animal Carcinogen A4 - Not Classifiable as a Human Carcinogen A5 - Not Suspected as a Human Carcinogen

Mutagenic Effects Mutagenic Ames test: positive.

Reproductive Effects Possible risk of impaired fertility.

Developmental Effects No information available.

Teratogenicity Teratogenic effects have occurred in experimental animals.

STOT - single exposure Respiratory system STOT - repeated exposure Liver Kidney Blood

Aspiration hazard No information available

Symptoms / effects,both acute and delayed

Ingestion causes severe swelling, severe damage to the delicate tissue and danger of perforation: Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing: Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should be investigated

Endocrine Disruptor Information No information available

Other Adverse Effects The toxicological properties have not been fully investigated.

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12. Ecological information Ecotoxicity Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. The product contains following substances which are hazardous for the environment.

Component Freshwater Algae Freshwater Fish Microtox Water Flea Chromium trioxide (CrO3) Not listed LC50: = 40 mg/L, 96h static

(Colisa fasciatus) Not listed Not listed

Persistence and Degradability Soluble in water Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility Will likely be mobile in the environment due to its water solubility.

13. Disposal considerations Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. Chemical waste generators must also consult local, regional, and national hazardous waste regulations to ensure complete and accurate classification.

14. Transport information

DOT

UN-No UN1463 Proper Shipping Name CHROMIUM TRIOXIDE, ANHYDROUS Hazard Class 5.1 Subsidiary Hazard Class 8; 6.1 Packing Group II

TDG

UN-No UN1463 Proper Shipping Name CHROMIUM TRIOXIDE, ANHYDROUS Hazard Class 5.1 Subsidiary Hazard Class 8; 6.1 Packing Group II

IATA

UN-No UN1463 Proper Shipping Name CHROMIUM TRIOXIDE, ANHYDROUS Hazard Class 5.1 Subsidiary Hazard Class 6.1, 8 Packing Group II

IMDG/IMO

UN-No UN1463 Proper Shipping Name CHROMIUM TRIOXIDE, ANHYDROUS Hazard Class 5.1 Subsidiary Hazard Class 6.1, 8 Packing Group II

15. Regulatory information

United States of America Inventory

Component CAS-No TSCA TSCA Inventory notification - Active/Inactive

TSCA - EPA Regulatory Flags

Chromium trioxide (CrO3) 1333-82-0 X ACTIVE R

Legend:

TSCA - Toxic Substances Control Act, (40 CFR Part 710) X - Listed '-' - Not Listed R - Indicates a substance that is the subject of a Section 6 risk management rule under TSCA.

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TSCA 12(b) - Notices of Export

Component CAS-No TSCA 12(b) - Notices of Export Chromium trioxide (CrO3) 1333-82-0 Section 6

International Inventories Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Australia (AICS), China (IECSC), Korea (ECL).

Component CAS-No DSL NDSL EINECS PICCS ENCS AICS IECSC KECL Chromium trioxide (CrO3) 1333-82-0 X - 215-607-8 X X X X KE-06020

U.S. Federal Regulations

SARA 313

Component CAS-No Weight % SARA 313 - Threshold

Values % Chromium trioxide (CrO3) 1333-82-0 >95 0.1

SARA 311/312 Hazard Categories See section 2 for more information

CWA (Clean Water Act) Component CWA - Hazardous

Substances CWA - Reportable

Quantities CWA - Toxic Pollutants CWA - Priority Pollutants

Chromium trioxide (CrO3) - - X -

Clean Air Act Component HAPS Data Class 1 Ozone Depletors Class 2 Ozone Depletors

Chromium trioxide (CrO3) X -

OSHA - Occupational Safety and Health Administration

Not applicable

Component Specifically Regulated Chemicals Highly Hazardous Chemicals

Chromium trioxide (CrO3) 5 µg/m3 TWA

2.5 µg/m3 Action Level

CERCLA Not applicable

California Proposition 65 This product contains the following Proposition 65 chemicals.

Component CAS-No California Prop. 65 Prop 65 NSRL Category

Chromium trioxide (CrO3)

1333-82-0 Carcinogen Developmental

Female Reproductive Male Reproductive

0.001 µg/day Developmental Carcinogen

U.S. State Right-to-Know Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Chromium trioxide (CrO3)

X X X X X

U.S. Department of Transportation Reportable Quantity (RQ): N DOT Marine Pollutant N DOT Severe Marine Pollutant N

U.S. Department of Homeland Security

This product does not contain any DHS chemicals.

Other International Regulations

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Mexico - Grade No information available

16. Other information Prepared By Health, Safety and Environmental Department

Email: tech@alfa.com www.alfa.com

Creation Date 24-Nov-2010 Revision Date 14-Feb-2020 Print Date 14-Feb-2020 Revision Summary SDS authoring systems update, replaces ChemGes SDS No. 1333-82-0.

Disclaimer The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text

End of SDS

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