Understanding the long term impact of covid-19 on the brain through advanced MR imaging and spectroscopy

Ended Project Grant Awarded Last action

Award ID
R01NS124065
Recipient
Awarding agency
Obligated
$8,574,791

Award facts

Completion date
Funding
  • $7,209,245.00 Federal
  • $1,365,546.00 Non-federal
Place of performance
Minneapolis, MN 55455, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Since the world health organization declared covid-19 a pandemic in march 2020, increasing evidence has shown that the disease affects multiple organs, including the central nervous system (CNS). Effects of covid-19 on the CNS in the acute phase were documented clinically, by magnetic resonance imaging (MRI) and spectroscopy (MRS), by plasma biomarkers and at autopsy, with neurological symptoms manifesting in 1/3 to 2/3 of hospitalized, severe cases. After the acute phase, approximately 10% of patients experience prolonged illness, during which neurological symptoms (headaches, cognitive blunting, and fatigue) are among the top 10 symptoms reported by covid-19 survivors. The underlying biology of these prolonged symptoms is unknown; therefore, prospective studies to systematically investigate the pathophysiology of such sequelae are urgently needed. Based on the clinical presentation of covid-19, reports of covid-related symptoms in the months following the infection, including reports of parkinsonism and other delayed neurological and neurocognitive complications ranging from mild-to-severe, and known peripheral triggers of cerebral pathology, neuroinflammation (aim 1), neurodegeneration (aim 2) and cerebrovascular disease (CVD) (aim 3) are expected to be important components of long-term CNS pathophysiology. The covid brain advanced imaging network (covid-brain) was formed as a consortium of six institutions to systematically and prospectively elucidate the long-term CNS pathophysiology of covid-19 using highly sensitive, harmonized, advanced MRI/MRS technology at 3 tesla in conjunction with standardized neurological and neuropsychological evaluation and inflammatory blood biomarkers. Five sites that currently partner in other multi-site neuroimaging initiatives (university of minnesota, mayo clinic rochester, harvard university/massachusetts general hospital, johns hopkins university, houston methodist research institute) will collect longitudinal multi-modal MRI (T1, flair, diffusion MRI, susceptibility-weighted MRI, single- and multi-voxel MRS and pseudo-continuous arterial spin labeling), clinical, neurocognitive and blood biomarker data from laboratory confirmed post-covid cases with neurological symptoms (n=200) and matched controls (n=100). The laboratory of neuro imaging (loni) at the university of southern california will serve as the data management site. Group differences and change over time in MR markers indicative of neuroinflammation, neurodegeneration, hypoxia/ischemia and CVD and their associations with specific neurological symptoms, cognitive function, and inflammatory blood biomarkers will be investigated. The mechanistic insights provided by this study will inform the care and treatment of patients that are expected to suffer long-term consequences of the pandemic for the years to come.

Transactions

Action Federal Non-federal Date
Amendment $620,430 $0
Amendment $0 $0
Amendment $0 $0
Amendment $615,261 $0
Amendment $615,261 $0
Amendment $638,887 $0
Amendment $638,887 $0
Amendment $449,809 $0
Amendment $449,809 $0
Amendment $449,809 $0
Amendment $644,224 $0
Amendment $644,224 $644,224
Amendment $721,322 $0
Original award $721,322 $721,322
Show all 14

Subawards

Subrecipient Amount Awarded
The Methodist Hospital Research Institute Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopy $32,942
The General Hospital Corporation $43,062
University Of Southern California $44,812
Mayo Clinic $61,713
The Johns Hopkins University $62,357
The Methodist Hospital Research Institute $235,001
The Johns Hopkins University Understanding the long term impact of COIVD 19 on the brain through advanced MR imaging and spectroscopy $239,685
The General Hospital Corporation Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and spectroscopy $452,555
Mayo Clinic Understanding the long term impact of COVID-19 on the brain through advanced MR imaging and Spectrscopy $363,269

Quick answers

Who received award R01NS124065?

R01NS124065 was awarded to Regents Of The University Of Minnesota by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on July 15, 2021.

How much is award R01NS124065 worth?

$8,574,791 has been obligated on R01NS124065: $7,209,245 in federal funding and $1,365,546 in non-federal funding.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login