Prisma Health - Upstate

Prisma Health - Upstate, doing business as Greenville Health System, is a non-profit hospital organization registered in SAM.gov since May 2006 and headquartered in Greenville, South Carolina. As a primary healthcare provider for the majority of Upstate South Carolina residents, Prisma Health - Upstate delivers comprehensive medical services including inpatient and outpatient care, emergency services, and specialized procedural interventions. The organization has established itself as a significant recipient of federal grant funding, with multiple active awards supporting both clinical care delivery and research initiatives. Through its Office of Sponsored Programs Division, Prisma Health - Upstate leverages federal grant awards to enhance healthcare capacity, develop innovative clinical programs, advance medical education, and address critical public health needs in underserved populations across South Carolina.

Prisma Health - Upstate has demonstrated substantial expertise in managing diverse federal grant portfolios across multiple funding agencies and program types. The organization has received prime federal grant awards from the Department of Veterans Affairs for adaptive sports programming serving disabled veterans and military service members, with three consecutive awards totaling over $1 million (CFDA 64.034) spanning 2021 through 2026. Additionally, the organization secured a congressionally directed spending grant for construction of cardiovascular procedural capacity at Patewood Hospital, addressing South Carolina's leading cause of death and projected service demand growth. Through partnerships with federal agencies including the National Institutes of Health, SAMHSA, and the Health Resources and Services Administration, Prisma Health - Upstate has implemented programs addressing substance use disorders, including a $3 million Rural Communities Opioid Response Program award focused on medication-assisted treatment access across four rural South Carolina counties, and an emergency department opioid alternatives initiative utilizing evidence-based pain management protocols. The organization has also received workforce training funding from the Appalachian Regional Commission and collaborated on medical education initiatives including sex and gender curriculum development in partnership with the University of South Carolina School of Medicine Greenville. As a sub-award recipient, Prisma Health - Upstate participates in numerous clinical research trials and demonstrations through partnerships with leading academic institutions including Wake Forest University Health Sciences, University of Alabama at Birmingham, Clemson University, the Medical University of South Carolina, and University of Maryland Baltimore, supporting oncology research networks, sickle cell treatment programs, trauma resilience initiatives, and specialized nursing training programs.