Posit Science Corporation

Posit Science Corporation, doing business as Posit Science Corp, a San Francisco-based for-profit company, delivers evidence-based cognitive training software and digital therapeutics to federal agencies as a prime recipient on NIH grants (87% of recent awards) and as a direct purchaser on small defense and civilian health contracts. The company operates exclusively in the commercial market without set-aside designations; recent prime work splits heavily toward National Institutes of Health grant awards while maintaining direct purchase orders with the Defense Health Agency, U.S. Army Training and Doctrine Command, U.S. Coast Guard, and U.S. Special Operations Command.

Posit Science's portfolio centers on computerized brain training platforms designed to enhance cognitive performance, memory, decision-making, and response inhibition in high-stress operational environments and aging populations. Core products include BrainHQ, a group enterprise cognitive training license; the Freeze Frame cognitive control intervention for spatial neglect syndrome following acquired brain injury; INHANCE-MCI, targeting cholinergic neurotransmission and cognitive decline in mild cognitive impairment; and RSTATE, a sleep-regulation and cognitive training program for older adults with insomnia. Representative federal work includes a $1,048,180 NIH National Institute of Neurological Disorders and Stroke grant (CFDA 93.853, awarded August 2026) to develop and commercialize a telehealth treatment platform for spatial neglect syndrome with FDA clearance and remote coaching; a $1,008,342 National Institute on Aging grant (CFDA 93.866, awarded September 2025) for a clinical trial of INHANCE-MCI in mild cognitive impairment; a $153,500 Army TRADOC purchase order (June 2024) for a BrainHQ group enterprise license; and a $32,325 Defense Health Agency purchase order (September 2025) for licensed training subscriptions supporting cognitive enhancement initiatives for military personnel.

Customer concentration is split between NIH grantmaking and defense purchasing. The National Institute on Aging leads by award count with nine awards, followed by the National Institute of Mental Health with five and the National Institute of Neurological Disorders and Stroke with two; these three entities account for 61% of recent awards across Posit Science's portfolio. By potential value, the ranking inverts: U.S. Special Operations Command anchors the defense segment with two awards totaling $6.6 million combined potential value, while the Army Training and Doctrine Command, Defense Health Agency, Veterans Health Administration, and Coast Guard round out direct federal purchasing with smaller individual orders. The vendor holds an indefinite delivery contract with USSOCOM (H9240021D0003) carrying $550 thousand in combined potential value and supporting one task order.

Activity has remained steady at two to four awards per year over the past five years, with four awards in 2025 and one in 2026. Four awards reach ultimate completion within the next twenty-four months, presenting modest recompete exposure. In its subrecipient role on NIH grants, Posit Science collaborates with the University of Iowa on behavioral intervention studies and with the University of Minnesota on neurocognitive computational assessment development. The company's federal grant footprint reflects heavy concentration in neuroscience, aging, and mental health research programs; combined obligated dollars ($25.6 million) exceed combined potential value ($6.8 million) by 279%, indicating a sustained history of grant receipts from NIH institutes across multiple program cycles extending back to 2009.