Project Grant R44NS147449
- The National Institute on Aging awarded Posit Science Corporation $1,008,342 on September 20, 2025, under the Aging Research program (CFDA 93.866) to conduct a prospective, double-blind, parallel-arm, active-controlled clinical trial of INHANCE-MCI, a computerized cognitive training program designed to enhance cholinergic neurotransmission and slow cognitive decline in individuals with mild cognitive impairment. The trial will randomize patients to intervention or active control arms and...
- The National Institute of Neurological Disorders and Stroke awarded $233,280 to the Regents of the University of Michigan on March 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to identify and address factors that delay acute stroke treatment delivery via telestroke. The project, titled "Understanding and Improving Acute Telestroke Care" and led by Principal Investigator Brian Stamm, MD, MSC, will characterize...
- The National Institute on Aging awarded Braincheck, Inc. $497,782 in a Project Grant (Aging Research, CFDA 93.866) on September 20, 2025, to develop and pilot-test BrainCheck eConsult, a secure digital platform enabling asynchronous consultations between primary care providers and dementia specialists. The project addresses limited access to dementia specialists in medically underserved and rural areas, where primary care providers increasingly manage cognitive decline despite inadequate...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $594,435 to Oregon Health & Science University on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to conduct research on pericyte phenotypic switching in diabetic post-stroke cognitive impairment. The project, R01NS146933, investigates the cellular and molecular...
- The National Institute of Neurological Disorders and Stroke awarded Northern California Institute For Research And Education, Inc. (NCIRE) $414,464 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research on sleep-dependent modulation of transplanted neural circuits for stroke recovery. The project characterizes the integration of human induced pluripotent stem cell (iPSC)-derived neurons transplanted...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $433,125 to the University of Texas Health Science Center at San Antonio on August 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of REST (Restrictive Element-1 Silencing Transcription Factor) in governing post-stroke neural plasticity and recovery. The...
- The National Institute of Neurological Disorders and Stroke awarded Aneuryst Inc. $492,110 on September 9, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds enzyme phenotyping of hydroxyfasudil to support preclinical development work for potential treatment of cerebral vasospasm following subarachnoid hemorrhage. The research advances foundational understanding of fasudil, a Rho-kinase inhibitor used in Japan for...
- The National Institute on Aging awarded Translucence Biosystems, Inc. $3,733,679 on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and refine a vasculature subtraction parenchymal quantification (VSPQ) workflow for measuring antibody therapeutic drug penetration in the brain. This Phase II project grant addresses technological gaps in current methods for quantifying the distribution of antibody-based therapeutics across the blood-brain barrier, which suffer from...
- The National Institute on Aging awarded Oscilloscape, Inc. $1,402,614 on September 20, 2025, under the Aging Research program (CFDA 93.866) to develop and test a wearable digital health device delivering music-based and synchronized visual brain stimulation therapy for adults with Alzheimer's disease and mild cognitive impairment. The device, called SYNG (SynchronyGamma), uses patented neural network technology to model and stimulate healthy brain rhythms through neural entrainment. Prototype...
- The National Institute of Child Health and Human Development awarded Duke University $646,000 on June 16, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a dosing and deployment trial of EyeMove, a home-based optokinetic treatment for ipsilesional gaze deviation in stroke survivors with spatial neglect. The project tests the feasibility and acceptability of deploying EyeMove in community settings with 50 stroke survivors who have persistent...
The National Institute of Neurological Disorders and Stroke awarded Posit Science Corporation $1,048,180 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and commercialize a telehealth treatment platform for spatial neglect syndrome (hemineglect) following acquired brain injury. The project delivers three integrated products: FDA clearance for a novel diagnostic assessment tool for hemineglect to be deployed on a commercially supported platform for rapid bedside detection; development of an integrated telehealth program incorporating the "Freeze Frame" cognitive control intervention, modeled on established telehealth programs in metabolic health and musculoskeletal rehabilitation; and remote coaching support including onboarding assistance, technical support, and motivational coaching to improve patient enrollment, initiation, and completion of the intervention. The work builds on prior published randomized controlled trial results demonstrating that Freeze Frame produces significant improvements in attention and cognitive control that extend to real-world functional capacity. Performance occurs in San Francisco, California, with a period of performance through July 31, 2028. The award targets a patient population of several million individuals with chronic hemineglect stemming from traumatic brain injury or stroke for whom existing treatment options remain limited.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/11/26 |