Endeavor Health Clinical Operations

Endeavor Health Clinical Operations Research Institute Division, doing business as Evanston Hospital, is a tax-exempt nonprofit hospital system and research institution headquartered in Evanston, Illinois, that acts as a federal grant recipient in biomedical and public health research. The organization does not hold federal contracts as a prime, but operates across 154 federal grants and grant sub-awards (62% prime recipient, 38% sub-recipient) with $73.3 million in combined potential value and $232.2 million in obligated federal dollars across a diverse portfolio of NIH-funded research spanning multiple institutes and centers.

Endeavor Health's capability portfolio centers on translational and clinical research in prostate and benign prostatic hyperplasia, maternal and child health, cardiovascular imaging, pain physiology, and precision medicine, grounded in institutional capacity for human tissue analysis, functional magnetic resonance imaging, clinical trial site operations, and workforce training. Representative prime recipient work includes a $774,368 SAMHSA Center for Mental Health Services grant awarded September 30, 2026 (CFDA 93.532) to implement the Zero Suicide Framework across primary care and emergency departments in Cook and Lake Counties, Illinois, screening approximately 89,500 patients and providing suicide-specific treatment through standardized assessment and evidence-based interventions including Collaborative Assessment and Management of Suicidality and Cognitive Behavioral Therapy for Suicide Prevention, running through September 29, 2031. A $989,566 SAMHSA Center for Substance Abuse Treatment grant (CFDA 93.490, also awarded September 30, 2026) funds the Community Engagement, Screening, Assessment, and Referral (CESAR) project to deploy universal SBIRT screening, brief intervention, peer recovery support, and coordinated referrals across 15 primary care practices, one federally qualified health center, three school-based health centers, and two hospitals serving approximately 36,130 youth ages 12–21 over five years. A National Heart, Lung, and Blood Institute award of $1,553,928 (July 15, 2026, CFDA 93.837) funds a five-year technical development and clinical validation program testing equilibrium phase BT1RESS MR angiography for improved cardiovascular imaging, addressing clinical limitations for patients unable to tolerate iodinated contrast agents. A $2 million Bureau of Justice Assistance Community-Based Violence Intervention and Prevention Initiative grant (CFDA 16.045, October 1, 2024) funds the "Endeavor to Heal" hospital-based community violence intervention program across three Endeavor Health hospitals on Chicago's North Side and North Suburbs, targeting high-risk individuals with rapid response crisis intervention, intensive case management, mental health services, and workforce development through September 30, 2027.

Customer concentration is heavily concentrated within the National Institutes of Health, which accounts for the top five funding sources by award count at 47% of recent awards. The Department of Health and Human Services National Institutes of Health Office of the Director anchors the portfolio with nine awards carrying $72.9 million in combined potential value, driven primarily by research infrastructure grants including a $1.3 million NIH Office of the Director award for 9.4T MRI gradient system replacement and imaging capability. The National Institute of Diabetes and Digestive and Kidney Diseases (16 awards), National Institute of Child Health and Human Development (13 awards), National Heart, Lung, and Blood Institute (10 awards), and National Cancer Institute (9 awards) collectively represent substantial research funding focused on organ-system disease mechanisms, reproductive health, and cancer biology. Activity has grown year over year from six awards in 2022 to twenty in 2025; thirteen awards reach ultimate completion within the next twenty-four months, creating moderate recompete exposure.

Endeavor Health operates as a sub-recipient on a substantial portfolio of NIH-funded research led by Northwestern University, University of Chicago, Washington University, Rutgers University, University of Illinois, and the University of Michigan, performing work ranging from tissue processing and clinical pathology analysis in maternal-fetal virology studies to kidney functional MRI image analysis, neural tissue modeling for neurodegenerative disease research, and patient recruitment and enrollment for multicenter clinical trials. Named subsidiaries include Northshore University Healthsystem, which appears in several grants as the operating entity for hospital-based clinical research infrastructure.