Collaborative Drug Discovery, Inc.

Collaborative Drug Discovery, Inc., based in Burlingame, California, delivers cloud-based scientific data management software and machine-learning-enabled drug-discovery informatics platforms to federal health research agencies as a prime contractor (73% of recent awards) and as a subcontractor on federal research grants. The company is a for-profit corporate entity competing predominantly in full-and-open federal procurement, with no SBA set-aside certifications across its recent federal footprint, though it has received one Total Small Business set-aside purchase order.

The vendor's core capability is the CDD Vault platform — a hosted, cloud-based system integrating biological and chemical databases, computational chemistry tools, and machine-learning-driven data management for pharmaceutical research operations and drug-discovery workflows. Recent prime contract work includes a $525,000 Total Small Business set-aside purchase order from the National Institute of Neurological Disorders and Stroke (awarded June 2026) for a centralized IT system supporting the NIH Blueprint Neurotherapeutics Network with performance in Hillsborough, California through June 2027; a $438,070 subscription license from the Defense Health Agency (awarded August 2024) for a CDD Vault package with performance through August 2029; and a $5,892 purchase order from CDC Pittsburgh (awarded April 2026) for the CDD Vault hosted platform, with performance in Atlanta, Georgia through March 2027. The vendor also holds a completed $5,095,804 cooperative agreement with the National Center for Advancing Translational Sciences (awarded June 2022) to develop virtual chemistry modules — deep-learning-based chemical modeling and machine-readable reaction informatics — for the NCATS ASPIRE drug-discovery automation project.

Customer concentration is acute within NIH. The top five NIH centers and institutes account for 82% of recent awards by count, led by the National Center for Advancing Translational Sciences (11 awards) and the National Institute of Child Health and Human Development (6 awards), with the National Institute of Neurological Disorders and Stroke anchoring the largest dollar value at $5.6 million combined potential across two awards. Ten distinct federal agencies appear across the footprint, but 82% of award count and 100% of combined potential value flows from HHS agencies — primarily NIH institutes and the CDC. The Defense Health Agency holds a secondary position with two awards totaling $442,000 in combined potential value.

Activity accelerated from one award per year in 2021–2022 to seven awards in 2025, with two awards reaching completion in the next twenty-four months (combined potential value $531,000). In its subcontractor role, the vendor provides CDD Vault platform instances and API access to the Regents of the University of Minnesota across multiple chemical synthesis and drug-discovery research grants spanning male contraception, protein structural biophysics, and display-element library screening campaigns, with sub awards dating to August 2024 and continuing through September 2025.