Case Western Reserve University (8313)

Case Western Reserve University, a research institution operating in the role of federal grant sub-recipient, participates in biomedical, environmental, and workforce research programs across federal health and science agencies, with 81% of recent awards flowing through sub-grant arrangements with prime grantees rather than direct federal funding. The university does not hold federal contracts or contract vehicles; all federal work is grant-funded, primarily through the National Institutes of Health (NIH).

Case Western's federal footprint centers on life sciences and translational research. The institution acts as a sub-recipient on NIH awards, with the National Institute on Aging (NIA) accounting for six awards across the recent portfolio — representing 63% of all awards by count. Recent representative sub-grant work includes a February 2026 sub-award from Weill Medical College of Cornell University (prime grantee) in which Case Western serves as an enrolling site for the DEPTH Study, a clinical trial examining doxycycline efficacy in pulmonary disease, with Dr. Yendewa functioning as the site principal investigator overseeing participant screening, enrollment, protocol adherence, and pulmonary function testing through week 72. The university also participates in environmental science research under a May 2025 sub-award from the University of Oregon on youth mental-health intervention following COVID-19, and in a separate workflow initiative for sustainability workforce development under a May 2025 sub-award from the University of Akron. The university's sub-recipient role on six Miami-based awards spanning 2022–2025 includes participation in Alzheimer's disease, spinal cord injury, and Alzheimer's-adjacent genetics research (RNA sequencing and functional ultrasound work).

Beyond the concentrated NIA pipeline, Case Western has received sub-awards from the Environmental Protection Agency's Office of Research and Development (October 2025 on PFAS adsorption modeling and machine-learning prediction via the State University of New York Research Foundation as prime), the Agency for Healthcare Research and Quality (health services research), and the National Heart, Lung, and Blood Institute (cardiovascular research). The combined potential value reported across all sixteen awards stands at $83 thousand, a figure that reflects sub-award line-item budgeting rather than total project scope; obligated dollars ($5.9 million) exceed this potential-value placeholder by a factor of seventy-one, indicating significant ongoing performance at the university level. Activity has accelerated in 2025, with six awards in that year alone compared to one or two annually from 2022–2024. Case Western competes in no set-aside categories and holds no SBA designations; the institution is a traditional research university operating as a federally funded research and development center participant within the NIH research ecosystem.