Characterizing the genetic risk for alzheimer disease in african and admixed african-american ancestries

Active Cooperative Agreement Awarded Last action

Award ID
U01AG084545
Recipient
Awarding agency
Obligated
$29,017,444

Award facts

Assistance listing
93.866 Aging Research
Completion date 42% complete
Place of performance
Miami, FL 33136, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Ad is the leading cause of dementia in the elderly in all ethnic and racial groups, but most genetic studies for ad are in non-hispanic whites (NHW) of european ancestry, resulting in a lack of generalizability of findings across more diverse ancestries. This is problematic, as initial studies in african americans (AA), who have a higher prevalence of ad compared to NHW, have already revealed differences in risk effect sizes in known loci (e.g., apoe; ABCA7), indicating multiple unique patterns of risk. Therefore, the alzheimer's disease sequencing project (adsp) aims to encompass the richest possible ethnic diversity and currently includes over 55,000 funded samples for whole genome sequencing (> 19,000 NHW, >14,000 HL ancestry, and > 8,000 african ancestry cases and controls). Thus, in this adsp-FUS 2.0 application, which focuses on the PAR-21-212 goal to increase diversity cohorts in the adsp, we are proposing generating whole genome sequencing, ad plasma biomarkers and cardiovascular disease biomarkers in an additional ~9,000 individuals of african ancestry (~5,000 african, ~4,000 african american) ascertained as part of the ongoing "recruitment and retention for alzheimer's disease diversity genetic cohorts in the adsp" (readd-adsp U19 AG074865). Further, we will acquire MRI data from 200 nigerian participants. We will perform longitudinal follow-up visits on mild cognitively impaired and cognitively unimpaired individuals after ~4 years to further evaluate clinical and biomarker level changes longitudinally associated with status conversion. This increase in sample size enhances our ability in this proposal to detect and analyze rare genetic variants contributing to the risk and protection of ad in individuals of african ancestry and understand underlying risk correlated with cardiovascular disease risk and ad plasma biomarkers. Taken together, this project will leverage the resources collected under the readd-adsp to begin to unravel the ad risk for individuals of african ancestry while providing an invaluable resource for the ad research community at-large.

Transactions

Action Obligated Date
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Original award $4,050,927
Show all 27

Subawards

Subrecipient Amount Awarded
Case Western Reserve University (8313) AWD-009959: AA FUS Sequencing - Nov 2023 Resubmission 09/30/2024 (version 2) $225,179
Indiana University (1673) $55,057
Case Western Reserve University (8313) $229,774
Trustees Of Indiana University $56,180
The Trustees Of Columbia University In The City Of New York $246,750
The Trustees Of The University Of Pennsylvania $218,528

Quick answers

Who received award U01AG084545?

U01AG084545 was awarded to University Of Miami by National Institute on Aging (National Institutes of Health) on September 30, 2024.

How much is award U01AG084545 worth?

$29,017,444 has been obligated on U01AG084545.

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