Advanced Regenerative Manufacturing Institute Inc.

Advanced Regenerative Manufacturing Institute Inc., doing business as Armi, a tax-exempt non-profit organization based in Manchester, New Hampshire, performs independent validation and verification services, biofabrication manufacturing standardization, and cluster-coordination work for federal health agencies as a prime recipient of federal grants and contracts. Armi competes full-and-open across nine distinct federal customer agencies, with no set-aside designation; the organization operates as a prime on 74% of recent awards and carries a named for-profit subsidiary, Armi Bioindustries Corp, certified as a Small Disadvantaged Business.

Armi's capability portfolio centers on regenerative medicine manufacturing, cell and tissue engineering standardization, and biofabrication infrastructure development. Its recent prime contract work includes a $17.87 million definitive contract awarded by the National Institutes of Health on June 1, 2026 for independent validation and verification services supporting the ARPA-H Resilient Extended Automatic Cell Therapies (REACT) program—scaling manufacturing capability for two engineered cell therapy devices, the "Living Pharmacy" and "Living Sentinel," through November 2028 on a time-and-materials basis. The Food and Drug Administration awarded Armi a $2.24 million definitive contract in September 2024 for the Biofab Foundry initiative, developing a scalable closed-system automated medical product manufacturing platform, extended through September 2027 under a cost-no-fee structure. Armi also received a $1.2 million project grant from the National Institute of Standards and Technology in October 2024 to develop standardized infrastructure and quality-by-design approaches for biofabrication assay development, specifically improving the Glucose Stimulated Insulin Secretion (GSIS) assay for automation and reproducibility across cell and tissue-based assays.

Customer concentration sits heavily with the Department of Health and Human Services, which anchors the dollar value—the HHS Office of the Assistant Secretary for Preparedness and Response (two awards, $29.3 million combined potential value) and HHS National Institutes of Health ($17.9 million combined potential value) together represent the largest contract tranches. The Department of Commerce Economic Development Administration dominates by award count (8 awards), funding cluster-development and regional biofabrication ecosystem work across multiple project grants totaling approximately $45 million for establishing Southern New Hampshire as a biomanufacturing hub. The top five customer agencies by combined potential value account for 100% of awards in the source dataset. A single recompete exposure—the FDA Biofab Foundry contract for $2.2 million—reaches ultimate completion within the next twenty-four months.

Armi's grant footprint is substantial. As prime recipient, the organization has received multiple Economic Development Administration project grants supporting the Biofabrication Cluster led by the City of Manchester, including awards of $31.2 million, $5.178 million, $4.67 million, and $4.2 million (all September 2022), alongside a $6.9 million cooperative agreement from HHS Office of the Assistant Secretary for Preparedness and Response (September 2022, extended through September 2025) to establish an ARMI Health Tech Hub program for bilateral U.S.-Israeli health technology and health security. Armi received a National Science Foundation project grant in March 2023 to host the NSF-ARMI BioFabUSA workshop on advanced tissue manufacturing standardization. As a sub-recipient, Armi has received grant sub-awards from Southern New Hampshire University (January 2025, scaling apprenticeship and pilot programs; August 2023, transportation equity study management), Case Western Reserve University (January 2025), and Bioindustrial Manufacturing And Design Ecosystem (September 2024).

Service Contract Inventory captures $6.3 million in SCI-reportable invoiced revenue in FY2024 across 0.1 FTEs (contract-level)—a minimal slice of Armi's federal footprint, reflecting that the bulk of recent work flows through grants and definitive contracts rather than service-contract vehicles. Government-paid hourly rates on SCI-reportable prime work run at a median of $2,014.95/hr. Across SCI-reportable prime contracts, subcontractors account for approximately 24% of contractor hours, with two named subcontractors reported; Armi's sub-engagement rate suggests modest reliance on subcontractor capacity relative to direct delivery. Activity has grown from two awards in 2023 to six in 2024, with a combined potential value of $49.4 million across 19 total awards, though obligations ($131.8 million) exceed potential value by 267%, indicating drawdowns against multi-year grant tranches and contract task order execution against higher ceilings than the source's potential-value snapshot captures.