Active Motif, Inc.

Active Motif, Inc., based in Carlsbad, California, manufactures genomic research tools, reagents, and sequencing services and performs ChIP-seq, ATAC-seq, RNA-seq, and multiome analysis for federal biomedical research agencies as a prime contractor (100% of recent awards). Active Motif is a self-certified small disadvantaged business competing predominantly under full-and-open procedures, with occasional total-small-business set-asides.

Active Motif's customer base concentrates heavily within the National Institutes of Health. The top five funding agencies account for 70% of combined potential value, led by the National Institute of Environmental Health Sciences (29 awards, $1 million combined potential value), followed by the National Center for Advancing Translational Sciences ($537 thousand across five awards), the National Institute of Allergy and Infectious Diseases (nine awards, $238 thousand), the Agricultural Research Service Midwest Area (two awards, $173 thousand), and the National Cancer Institute (six awards, $161 thousand). Recent capability work includes a $405 thousand purchase order from the National Center for Advancing Translational Sciences for single-nuclei multiome analysis of human brain tissue and induced pluripotent stem cell-derived cells, a $309.75 thousand order from the National Institute of Environmental Health Sciences for FactorPath ChIP-seq and epigenetic profiling of patient-derived dermal fibroblasts, a $129.4 thousand total-small-business purchase order from the USDA Agricultural Research Service for ATAC-seq analysis of barley gene promoters to support powdery mildew resistance research, and a $43.6 thousand total-small-business purchase order from the USDA Midwest Area for CUT & TAG assay services to assess chromatin accessibility in bovine monocytes. A $23.3 thousand purchase order from the National Institute of Diabetes and Digestive and Kidney Diseases, awarded in September 2026, covered sigma flag agarose, sample qualification assays, six full-scale ChIP-seq assays, and pooled input materials.

Active Motif holds federal grants as prime recipient. The National Human Genome Research Institute awarded a $306.1 thousand Project Grant (CFDA 93.172, Human Genome Research program) with performance through August 2026 for development of a novel epigenetic editing platform using targeted recruitment of epigenetic effectors to specific genomic loci. The National Institute on Aging awarded a $314.3 thousand Project Grant for development and validation of the Microscopic Imaging of Epigenetic Age (MIEPIage) platform, a single-cell method to quantify epigenetic changes and detect cellular rejuvenation following partial reprogramming in vivo.

Award volume has contracted sharply — four awards in 2022, six in 2023, four in 2024, one in 2025, and one in 2026 — with only one award (combined potential value $23 thousand) reaching ultimate completion in the next twenty-four months. Combined potential value across 158 recent awards stands at $3 million, though combined dollars obligated across all awards total $8.2 million, indicating that historical invoiced revenue on these purchase orders and grants exceeds the current forward pipeline significantly. Work is performed at Active Motif's Carlsbad, California facility.