Opioid STR

Active

Assistance listing
93.788
Agency
Grant awards
646 $23,646,807,599 in federal obligations

Program facts

Also known as
State Opioid Response
Assistance types
  • Project Grant
  • Formula Grant
Treasury account
  • 75-1364-0-1-551
More information

Program details come from SAM.gov Assistance Listings. Updated . Grant award figures come from USAspending.gov.

About this program

The Department of Health and Human Services Substance Abuse and Mental Health Services Administration (SAMHSA) awards grants under the Opioid STR program (CFDA 93.788) to address opioid and stimulant use disorders through prevention, treatment, and recovery support services, with the most recent awards disbursed on September 30, 2026.

The program funds medication-assisted treatment using FDA-approved medications for opioid use disorder, prescription drug monitoring program improvements, healthcare practitioner training in pain management and overdose prevention, access to opioid treatment programs, and other public health activities addressing opioid abuse. State Single State Agencies and territories are eligible under the State Opioid Response (SOR) track; federally recognized tribes and tribal organizations are eligible under the Tribal Opioid Response (TOR) track and may apply individually, as consortia, or in partnership with urban Indian organizations.

Recent grant activity is strong. The program has awarded 646 grants since May 2017, with significant acceleration: 116 awards in 2022, 197 in 2024, and 5 in the current year through September 2026. Combined federal dollars obligated total $23.65 billion, with an additional $1.32 billion in non-federal cost-share, bringing total obligated dollars to $24.97 billion. The assistance portfolio is predominantly Project Grants (91% of 588 awards) with a smaller share of Formula Grants (9% of 58 awards). SAMHSA funds 100% of the portfolio across both its identified funding streams.

Award magnitudes range widely. Recent tribal and state recipients include large state allocations—Florida received $739.691 million (September 2024), New Hampshire $234.938 million (September 2024), and Oklahoma $144.832 million (September 2024)—alongside smaller tribal and rural projects typically ranging from $1.2 million to $3.5 million over five years. Specific recent awards include Fallon Paiute Shoshone Tribe's medication-assisted treatment expansion ($379,685), Central Council Tlingit and Haida's overdose prevention initiative in Southeast Alaska ($895,401), Sac and Fox Nation's integrated behavioral health continuum ($298,467), and Southcentral Foundation's trauma-informed treatment and harm reduction services in Anchorage ($3.679 million).

Two active grant opportunities are open. Tribal Opioid Response (TI-26-012) closes July 16, 2026 and supports federally recognized tribes and tribal organizations addressing opioid and stimulant use disorders through the full continuum of prevention, treatment, and recovery services. Emergency Department Alternatives to Opioids Program (TI-26-018) closes July 27, 2026 and funds organizations developing non-pharmacological pain management alternatives in hospital and emergency department settings to reduce opioid-related harms.

Objective and description

Objective

Addressing the opioid crisis within such States, used for carrying out activities that supplement activities pertaining to opioids undertaken by the State agency responsible for administering the substance abuse prevention and treatment block grant

Description

Addressing the opioid crisis within such States, used for carrying out activities that supplement activities pertaining to opioids undertaken by the State agency responsible for administering the substance abuse prevention and treatment block grant under subpart II of part B of title XIX of the Public Health Service Act (42 U.S.C. 300x-21 et seq.); and Tribes and Tribal Organizations to address the opioid crisis within their communities.

Eligibility

Applicant eligibility

For the State Opioid Response (SOR) program - eligibility is limited to Single State Agencies (SSAs) and territories. Note: Tribes will be eligible to apply under a separate announcement. For the Tribal Opioid Response (TOR) program applicants must be a federally recognized American Indian or Alaska Native tribe or tribal organization. Tribes and tribal organizations may apply individually, as a consortia, or in partnership with an urban Indian organization. Indian Tribe, as defined at 25 U.S.C. § 1603(14) is any Indian tribe, band, nation, or other organized group or community, including any Alaska Native village or group or regional or village corporation as defined in or established pursuant to the Alaska Native Claims Settlement Act (85 Stat. 688) [43 U.S.C.A. § 1601 et seq.], which is recognized as eligible for the special programs and services provided by the United States to Indians because of their status as Indians. Tribal Organization, as defined at 25 U.S.C. § 1603(26) is the recognized governing body of any Indian tribe; any legally established organization of Indians which is controlled, sanctioned, or chartered by such governing body or which is democratically elected by the adult members of the Indian community to be served by such organization and which includes the maximum participation of Indians in all phases of its activities. Provided that in any case where a contract is let or grant made to an organization to perform services benefiting more than one Indian tribe, the approval of each such Indian tribe shall be a prerequisite to the letting or making of such contract or grant.

Uses of assistance

Uses: (A) Improving State prescription drug monitoring programs. (B) Implementing prevention activities,, and evaluating such activities to identify effective strategies to prevent opioid abuse. (C) Training for health care practitioners, such as best practices for prescribing opioids, pain management, recognizing potential cases of substance abuse, referral of patients to treatment programs, and overdose prevention. (D) Supporting access to health care services, including those services provided by Federally certified opioid treatment programs or other appropriate health care providers to treat substance use disorders. (E) Other public health-related activities, as the State determines appropriate, related to addressing the opioid abuse crisis within the State. Limitations: (1) notwithstanding any transfer authority in any appropriations Act, shall not be used for any purpose other than the grant program in subsection (c); and (2) shall be subject to the same requirements as substance abuse prevention and treatment programs under titles V and XIX of the Public Health Service Act (42 U.S.C. 290aa et seq., 300w et seq.).

Use restrictions

Limitations: (1) notwithstanding any transfer authority in any appropriations Act, shall not be used for any purpose other than the grant program in subsection (c); and (2) shall be subject to the same requirements as substance abuse prevention and treatment programs under titles V and XIX of the Public Health Service Act (42 U.S.C. 290aa et seq., 300w et seq.).

Length and time phasing of assistance

Each annual allotment is available for obligation by the State during the fiscal year in which it was allotted.

How to apply

Award procedure

Applications are awarded directly by SAMHSA to the applicant organization after a number of considerations, including but not limited to merit review, program analysis, and the Center for Substance Abuse Treatment National Advisory Council concurrence.

Grant opportunities

Opportunity Status Posted Applications due
Tribal Opioid Response TI-26-012 Closed
Emergency Department Alternatives to Opioids Program TI-26-018 Closed
Tribal Opioid Response TI-24-009 Closed
State Opioid Response Grants TI-24-008 Closed
Comprehensive Opioid Recovery Centers TI-23-020 Closed
Emergency Department Alternatives to Opioids Demonstration Program (ED-ALT) TI-23-010 Closed
Tribal Opioid Response Grants TI-22-006 Past —
State Opioid Response Grants TI-22-005 Past —
State Opioid Response (SOR) Technical Assistance TI-22-007 Past —
Tribal Opioid Response Grants TI-21-007 Closed
State Opioid Response Grants TI-20-012 Closed
Rota TI-20-009 Closed
SOR TA TI-20-008 Closed
Comprehensive Opioid Recovery Centers TI-20-006 Closed
Emergency Department Alternatives to Opioids Demonstration Program TI-20-005 Closed
Rural Opioid Technical Assistance Grants TI-19-010 Closed
Rural Opioids Technical Assistance Grants TI-18-022 Closed
Tribal Opioid Response Grants TI-18-016 Closed
State Opioid Response Grants TI-18-015 Closed
Opioid State Targeted Response (STR) Supplement (Short Title: STR Supplement) TI-18-020 Closed
FY 2018 Opioid State Targeted Response Technical Assistance (Short Title: STR TA) TI-18-004 Closed
Show all 21

Grant awards

Award Recipient Federal obligations Awarded
SAC and FOX nation healing pathways initiative - the SAC and FOX nation proposes the healing pathways initiative, a… H79TI088991 Sac & Fox Nation $298,467
Healing pathways for strong communities (hpsc) is a statewide prevention initiative led by the alaska native tribal… H79TI088898 Alaska Native Tribal Health Consortium $2,089,272
Southeast alaska tribal prevention & community resilience initiativeeducating communities. Empowering first responders… H79TI088875 Central Council Tlingit And Haida Indian Tribes Of Alaska $895,401
Northwest portland area indian health board tribal opioid response consortium phase 7 (TOR7) - established in 1972… H79TI088832 Northwest Portland Area Indian Health Board $1,104,329
Tribal opioid response: the purpose is address the ouds and aods in tribal communities byproviding medication… H79TI088773 Fallon Paiute Shoshone Tribe $379,685
Npaihb tribal opioid response consortium phase 6 - established in 1972, northwest portland area indian health board… H79TI088067 Northwest Portland Area Indian Health Board $55,354,955
Assist in addressing the opioid overdose crisis in tribal communities by increasing access to FDA-approved… H79TI088060 Kiowa Tribe Of Oklahoma $1,567,576
Tribal opioid project - he cheyenne and arapaho (c & a) tribes are applying for the 2024 tribal opioid response project… H79TI088053 Cheyenne Arapaho Tribe $3,088,725
Navajo nation tribal opioid response - the navajo nation (NN) is a federally recognized tribe and proposes to lead… H79TI087980 Navajo Nation Tribal Government $11,766,794
Shoshone-paiute tribes opioid prevention, response and treatment project - the shoshone-paiute tribes of the duck… H79TI087976 Shoshone-Paiute Tribes $1,749,545

Latest 10 of 646 listed here. See the rest on GovTribe.

Top recipients by federal obligations

10 of 288 recipients listed here. See the rest on GovTribe.

Federal obligations by fiscal year

Fiscal year Federal obligations
FY2026 $1,712,220,269
FY2025 $457,875,273
FY2024 $5,638,444,880
FY2023 $380,107,173
FY2022 $320,903,387
FY2021 $1,385,746,144
FY2020 $1,504,383,926
FY2019 $1,471,352,784
FY2018 $1,491,704,587
FY2017 $484,491,949

Quick answers

What is Assistance Listing 93.788?

Assistance Listing 93.788 is Opioid STR, a federal grant program run by Substance Abuse and Mental Health Services Administration (Department of Health and Human Services).

What is the CFDA number for Opioid STR?

Its CFDA number is 93.788: Assistance Listing numbers were called CFDA numbers before 2018.

How much funding has Assistance Listing 93.788 awarded?

646 grant awards under 93.788 have obligated $23,646,807,599 in federal funds to 288 recipients.

Who receives the most funding from 93.788?

The recipients obligated the most under Opioid STR are California Department Of Health Care Services ($1,777,595,224), Florida Department Of Children And Families ($1,395,916,170) and Pennsylvania Department Of Drug And Alcohol Programs ($1,272,728,608).

How much did 93.788 obligate in fiscal year 2025?

Grants under 93.788 obligated $457,875,273 in federal funds in fiscal year 2025.

Are there open grant opportunities under 93.788?

No opportunity listed under 93.788 is open now. The latest, Tribal Opioid Response, was posted on March 20, 2026.

On GovTribe

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