NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)

Open Posted

Opportunity number
PA-25-306
Agency
Applications due
Award size
Not on record

Opportunity facts

Funding instrument
Grant
Categories
  • Health
  • Income Security and Social Services
  • Environment
  • Education
Eligible applicants
  • 501(c)(3) Nonprofits
  • State Governments
  • Special District Governments
  • Independent School Districts
  • Higher Education Inst. (Private)
  • Public or Indian Housing Auth.
  • Small Businesses
  • Higher Education Inst. (Public)
  • Other
  • City/Township Governments
  • Tribal Governments (Federally Recognized)
  • Non-501(c)(3) Nonprofits
  • For Profit Organizations
  • County Governments
  • Tribal Organizations (Not Federally Recognized)
Points of contact
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institutes of Health seeks applicants for the Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required) with an application due date of January 7, 2028. This opportunity mandates that at least one clinical trial be proposed; projects must align with the programmatic interests of one or more participating NIH Institutes and Centers based on their scientific missions.

Eligible applicants include 501(c)(3) nonprofits, state and local governments, independent school districts, higher education institutions (public and private), tribal governments and organizations, public or Indian housing authorities, small businesses, for-profit organizations, and other eligible entities including HBCUs, HSIs, TCCUs, and non-domestic entities.

The program supports early and conceptual stages of exploratory and developmental research projects involving considerable risk but with potential for breakthrough discoveries or novel techniques, agents, methodologies, models, or applications with major impact on biomedical, behavioral, or clinical research. Some participating NIH ICs accept only mechanistic studies meeting NIH's definition of a clinical trial through this funding opportunity.

Related Assistance Listing numbers include 93.394 (Cancer Detection and Diagnosis Research), 93.395 (Cancer Treatment Research), 93.393 (Cancer Cause and Prevention Research), 93.837 (Cardiovascular Diseases Research), 93.838 (Lung Diseases Research), 93.839 (Blood Diseases and Resources Research), 93.172 (Human Genome Research), 93.173 (Research Related to Deafness and Communication Disorders), 93.242 (Mental Health Research Grants), 93.273 (Alcohol Research Programs), 93.279 (Drug Use and Addiction Research Programs), 93.286 (Discovery and Applied Research for Technological Innovations to Improve Human Health), 93.307 (Minority Health and Health Disparities Research), 93.361 (Nursing Research), 93.399 (Cancer Control), 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research), 93.855 (Allergy and Infectious Diseases Research), 93.865 (Child Health and Human Development Extramural Research), 93.866 (Aging Research), 93.867 (Vision Research), 93.879 (Medical Library Assistance), 93.113 (Environmental Health), 93.143 (NIEHS Superfund Hazardous Substances Basic Research and Education), 93.213 (Research and Training in Complementary and Integrative Health), 93.233 (National Center on Sleep Disorders Research), 93.396 (Cancer Biology Research), and 93.840 (Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders).

Synopsis

2 versions

Update #2 · Latest ·

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Update #1 ·

The NIH Exploratory/Developmental Grant supports exploratory and developmental research projects by providing support for the early and conceptual stages of these projects. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research. This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Files

File Type Posted
PA-25-306-Full-Announcement.html HTML file
PKG00289733.pdf PDF

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