Development of Candidate Medical Countermeasures (MCMs) and Technologies Against Radiological/Nuclear or Chemical Threats (U01 Clinical Trial Not Allowed)

Open Posted

Opportunity number
RFA-AI-27-014
Agency
Applications due
Award size
Not on record

Opportunity facts

Funding instrument
Cooperative Agreement
Category
  • Health
Eligible applicants
  • Independent School Districts
  • Tribal Governments (Federally Recognized)
  • Small Businesses
  • Special District Governments
  • Tribal Organizations (Not Federally Recognized)
  • City/Township Governments
  • 501(c)(3) Nonprofits
  • Higher Education Inst. (Public)
  • Public or Indian Housing Auth.
  • Other
  • Higher Education Inst. (Private)
  • For Profit Organizations
  • County Governments
  • State Governments
  • Non-501(c)(3) Nonprofits
Points of contact

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institute of Allergy and Infectious Diseases (NIAID) is forecasting cooperative agreement funding to support development of medical countermeasures and technologies against radiological, nuclear, or chemical threats, with applications due October 9, 2028. Clinical trials are not allowed. NIAID administers the program on behalf of NIH through the Radiation and Nuclear Countermeasures Program (RNCP) and Chemical Countermeasures Research Program (CCRP), with participation from the National Eye Institute, National Heart Lung and Blood Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institute on Drug Abuse, and National Institute of Neurological Disorders and Stroke.

Eligible applicants include higher education institutions (public and private), nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations, state and local governments, tribal governments and organizations, school districts, and housing authorities. Foreign organizations and foreign subawards or subcontracts are not eligible; unfunded international collaborations and foreign consultants are permitted. NIAID intends to commit $12 million in FY 2027 to fund 18–20 awards across Research Areas 1, 2, and 4, with $3 million for one award in Research Area 3 (Nonhuman Primate Radiation Survivor Cohort). Award budgets are capped at $350,000 per year in direct costs, except Research Area 3 awards, which may reach $2 million. The maximum project period is five years.

Research Areas include: (1) Radiation MCMs, models, and natural history; (2) Biodosimetry; (3) Nonhuman Primate Radiation Survivor Cohort; and (4) Chemical Countermeasures targeting government-designated Chemicals of Concern (anticoagulants, blood agents, cholinergic agents, convulsants, hemolytic agents, pulmonary irritants, ultra-potent synthetic opioids, and vesicants). Applications must address post-exposure MCM administration—minimum 24 hours post-irradiation for radiation MCMs or post-exposure for chemical countermeasures in civilian mass casualty settings. Applicants must submit preliminary data supporting intended use, well-defined experimental methods suitable for mass-casualty settings, annual benchmarks for assessing progress, and a data management and sharing plan. Scientific review is conducted by an appropriate Scientific Review Group, followed by secondary review by the National Advisory Allergy and Infectious Diseases Council. The cooperative agreement structure indicates substantial NIH programmatic involvement, including participation in monthly and annual meetings and guidance on remediation if benchmarks are not met.

Assistance Listing / CFDA: 93.855 (Allergy and Infectious Diseases Research).

Synopsis

The purpose of this notice of funding opportunity (NOFO) is to support research that advances understanding of the natural history of radiation or chemical exposures; develops relevant injury models; identifies and validates diagnostic tools, biomarkers, or triage technologies; and supports the development of effective medical countermeasures (MCMs) to mitigate or treat acute and/or delayed injuries resulting from radiological/nuclear or chemical public health emergencies.

Eligibility

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Files

File Type Posted
PKG00294097.pdf PDF
RFA-AI-27-014-Full-Announcement.html HTML file

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