Research Opportunity Announcement (ROA): All of Us Biobank
Closed Solicitation Posted
- Solicitation number
- OTA-25-002
- Agency
-
National Institutes of Health
Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541720 Research and Development in the Social Sciences and Humanities
- PSC
- AB23 Community & Regional Development R&D Svcs; Area & Regional Development; Experimental Development
- Place of performance
- Bethesda, Maryland 20892, United States
- Points of contact
-
- All of Us DCD Award Requirements allofusdcdawardrequirements@nih.gov
Notice details come from SAM.gov. Updated .
About this opportunity
The National Institutes of Health (NIH) Office of the Director is seeking a single Other Transactions (OT) award to maintain and expand the All of Us Biobank operations. This research opportunity aims to support biospecimen collections, processing, workflows, long-term storage, and distribution of high-quality diverse biospecimens. The solicitation follows a three-phase competitive process: Phase I involves submission of a full technical proposal, Phase II is an invited demonstration of laboratory and research capabilities with a cost proposal, and Phase III involves negotiation and award. Proposers must demonstrate the ability to transition, maintain, and sustain biobank operations within 12 months of award, with capabilities to innovate and apply emerging technologies. Key submission dates include a pre-submission webinar on December 3, 2024, a letter of intent due by December 9, 2024, and the full proposal due by December 27, 2024.
The contract will be awarded without a specific set-aside, and the initial award period is anticipated to be up to five years. The first year's funding range is estimated between $13 million and $50 million, with the selected organization responsible for managing over 14 million existing biospecimens and processing 800-1,200 participant collections daily. The primary place of performance will be in Bethesda, MD, with current biospecimen storage facilities located in Rochester, MN and Jacksonville, FL. The successful proposer will need comprehensive capabilities including biospecimen laboratory operations, research development, nationwide logistics support, and extensive documentation systems. The program currently supports biospecimen collections from approximately 845,000 participants, with storage capacities including 8.6 million blood tubes, 200,000 DNA samples from saliva, and 3.7 million urine samples. The NIH seeks an organization that can not only maintain current operations but also innovate and improve biospecimen management processes.
Notice text
3 versions
Update #3 · Latest ·
Overview:
The All of Us Research Program, within the Office of the Director (OD) at the National Institutes of Health (NIH), has issued a research opportunity announcement to solicit proposals. A ROA is a method of solicitation that announces the anticipated availability of Other Transactions (OT) awards, a special type of legal instrument other than contracts, grants, or cooperative agreements.
Purpose:
The purpose of this announcement is to fund one award that will maintain the existing biobank specimens and expand the All of Us Biobank to support the biospecimen collections, processes, workflows, methods, services, long-term storage, access and distribution of high-quality diverse biospecimens leading to the generation and dissemination of data derived from these samples.
This Research Opportunity Announcement (ROA) processes include three phases for the submission, downstream review and evaluation, and selection of oneproposal. These phases aim to identify a proposer that has, or can readily, transit, maintain and sustain the All of Us Biobank operations within 12 months of award, and is also capable of innovating and applying novel or emerging technologies, techniques, and processes to fulfill the scope described herein.
The three phases include the following:
- Phase I – Submission and Evaluation of Full Technical Proposal
- Phase II – Biospecimen Laboratory, Storage and Research & Development Capabilities Demonstration and Evaluation and Cost/Budget Proposal Submission (Invitation Only)
- Phase III – Negotiation and Other Transactions (OT) Award (Invitation Only)
The NIH intends to down-select at each phase resulting in making one OT award in Phase III. Depending on program requirements, the NIH reserves the right to omit Phase II Biospecimen Laboratory, Storage and Research & Development Capabilities Demonstration and Evaluation, and/or to combine the Phase submissions, as needed.
Award Project Duration: Award periods are anticipated to be up to five (5) years but may be shortened or extended as needed.
Pre-Submission Webinar: A webinar will be conducted on 03 December 2024 at 1:00 pm EST.
All attendees are required to register. Registration will remain open until the webinar end time. Questions to be addressed during the webinar must be emailed to AllofUsDCDAwardRequirements@nih.gov by 25 November 2024, 10:00 a.m.EST.
Letter of Intent
NIH is requesting that proposers who intend to submit a proposal in response to this ROA complete the Intent to Submit Proposal Form (Appendix B) and submit it to AllofUsDCDAwardRequirements@nih.gov by 09 December 2024, 10:00 a.m. EST. Although a letter of intent is not binding and does not enter into the review of a subsequent proposal, the information that it contains allows the All of Us Research Program to estimate the potential review workload and plan the review.
Documents and Related Links: The full ROA package is attached in the 'Attachments/Links' section. Potential proposers are encouraged to carefully review the announcement before submitting questions and/or letters of intent. A link to the All of Us Research Program webpage has been provided for additional information about our program.
AMENDMENT 2 - DECEMBER 18, 2024 - This announcement has been revised as follows:
1. 8.1.5 Proposal Review/Evaluation Process and Selection
2. Frequently Asked Question (FAQ) Document - an updated FAQ document with questions and answers has been uploaded under the ‘Attachments/Links’ section for the Biobank ROA.
AMENDMENT 1 - DECEMBER 12, 2024 - This announcement has been revised as follows:
1. 8.1.2 Proposal Format – the ‘Appendix 1: Key Personnel NIH Biosketches and Resumes’ content has been revised.
2. 8.1.3 Proposal Content - the Key Personnel content has been updated.
3. Webinar Slides and Recording - the presentation slides and recording have been uploaded under the ‘Attachments/Links’ section.
4. Frequently Asked Questions (FAQ) Document - a FAQ document with questions and answers has been uploaded under the ‘Attachments/Links’ section for the Biobank ROA.
Update #2 ·
Overview:
The All of Us Research Program, within the Office of the Director (OD) at the National Institutes of Health (NIH), has issued a research opportunity announcement to solicit proposals. A ROA is a method of solicitation that announces the anticipated availability of Other Transactions (OT) awards, a special type of legal instrument other than contracts, grants, or cooperative agreements.
Purpose:
The purpose of this announcement is to fund one award that will maintain the existing biobank specimens and expand the All of Us Biobank to support the biospecimen collections, processes, workflows, methods, services, long-term storage, access and distribution of high-quality diverse biospecimens leading to the generation and dissemination of data derived from these samples.
This Research Opportunity Announcement (ROA) processes include three phases for the submission, downstream review and evaluation, and selection of oneproposal. These phases aim to identify a proposer that has, or can readily, transit, maintain and sustain the All of Us Biobank operations within 12 months of award, and is also capable of innovating and applying novel or emerging technologies, techniques, and processes to fulfill the scope described herein.
The three phases include the following:
- Phase I – Submission and Evaluation of Full Technical Proposal
- Phase II – Biospecimen Laboratory, Storage and Research & Development Capabilities Demonstration and Evaluation and Cost/Budget Proposal Submission (Invitation Only)
- Phase III – Negotiation and Other Transactions (OT) Award (Invitation Only)
The NIH intends to down-select at each phase resulting in making one OT award in Phase III. Depending on program requirements, the NIH reserves the right to omit Phase II Biospecimen Laboratory, Storage and Research & Development Capabilities Demonstration and Evaluation, and/or to combine the Phase submissions, as needed.
Award Project Duration: Award periods are anticipated to be up to five (5) years but may be shortened or extended as needed.
Pre-Submission Webinar: A webinar will be conducted on 03 December 2024 at 1:00 pm EST.
All attendees are required to register. Registration will remain open until the webinar end time. Questions to be addressed during the webinar must be emailed to AllofUsDCDAwardRequirements@nih.gov by 25 November 2024, 10:00 a.m.EST.
Letter of Intent
NIH is requesting that proposers who intend to submit a proposal in response to this ROA complete the Intent to Submit Proposal Form (Appendix B) and submit it to AllofUsDCDAwardRequirements@nih.gov by 09 December 2024, 10:00 a.m. EST. Although a letter of intent is not binding and does not enter into the review of a subsequent proposal, the information that it contains allows the All of Us Research Program to estimate the potential review workload and plan the review.
Documents and Related Links: The full ROA package is attached in the 'Attachments/Links' section. Potential proposers are encouraged to carefully review the announcement before submitting questions and/or letters of intent. A link to the All of Us Research Program webpage has been provided for additional information about our program.
AMENDMENT 1 - DECEMBER 12, 2024 - This announcement has been revised as follows:
1. 8.1.2 Proposal Format – the ‘Appendix 1: Key Personnel NIH Biosketches and Resumes’ content has been revised.
2. 8.1.3 Proposal Content - the Key Personnel content has been updated.
3. Webinar Slides and Recording - the presentation slides and recording have been uploaded under the ‘Attachments/Links’ section.
4. Frequently Asked Questions (FAQ) Document - an FAQ document with questions and answers has been uploaded.
Update #1 ·
Overview:
The All of Us Research Program, within the Office of the Director (OD) at the National Institutes of Health (NIH), has issued a research opportunity announcement to solicit proposals. A ROA is a method of solicitation that announces the anticipated availability of Other Transactions (OT) awards, a special type of legal instrument other than contracts, grants, or cooperative agreements.
Purpose:
The purpose of this announcement is to fund one award that will maintain the existing biobank specimens and expand the All of Us Biobank to support the biospecimen collections, processes, workflows, methods, services, long-term storage, access and distribution of high-quality diverse biospecimens leading to the generation and dissemination of data derived from these samples.
This Research Opportunity Announcement (ROA) processes include three phases for the submission, downstream review and evaluation, and selection of oneproposal. These phases aim to identify a proposer that has, or can readily, transit, maintain and sustain the All of Us Biobank operations within 12 months of award, and is also capable of innovating and applying novel or emerging technologies, techniques, and processes to fulfill the scope described herein.
The three phases include the following:
- Phase I – Submission and Evaluation of Full Technical Proposal
- Phase II – Biospecimen Laboratory, Storage and Research & Development Capabilities Demonstration and Evaluation and Cost/Budget Proposal Submission (Invitation Only)
- Phase III – Negotiation and Other Transactions (OT) Award (Invitation Only)
The NIH intends to down-select at each phase resulting in making one OT award in Phase III. Depending on program requirements, the NIH reserves the right to omit Phase II Biospecimen Laboratory, Storage and Research & Development Capabilities Demonstration and Evaluation, and/or to combine the Phase submissions, as needed.
Award Project Duration: Award periods are anticipated to be up to five (5) years but may be shortened or extended as needed.
Pre-Submission Webinar: A webinar will be conducted on 03 December 2024 at 1:00 pm EST.
All attendees are required to register. Registration will remain open until the webinar end time. Questions to be addressed during the webinar must be emailed to AllofUsDCDAwardRequirements@nih.gov by 25 November 2024, 10:00 a.m.EST.
Letter of Intent
NIH is requesting that proposers who intend to submit a proposal in response to this ROA complete the Intent to Submit Proposal Form (Appendix B) and submit it to AllofUsDCDAwardRequirements@nih.gov by 09 December 2024, 10:00 a.m. EST. Although a letter of intent is not binding and does not enter into the review of a subsequent proposal, the information that it contains allows the All of Us Research Program to estimate the potential review workload and plan the review.
Documents and Related Links: The full ROA package is attached in the 'Attachments/Links' section. Potential proposers are encouraged to carefully review the announcement before submitting questions and/or letters of intent. A link to the All of Us Research Program webpage has been provided for additional information about our program.
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