All of Us Biobank - Amendment 2 December 18 2024.pdf

This is Amendment 2 to Research Opportunity Announcement (ROA) OTA-25-002 for the NIH All of Us Biobank Research Program, issued with an issue date of December 18, 2024. The amendment makes two key changes: 1) It revises Section 8.1.5 regarding the proposal review/evaluation process by removing references to Section 8.1.6 and updating the evaluation criteria to only reference Section 8.1.4, and 2) It adds an updated FAQ document under the Attachments/Links section. The amendment explicitly states that all other ROA information and requirements remain unchanged and in effect.

The parent opportunity seeks to fund one award to maintain existing biobank specimens and expand the All of Us Biobank operations through an Other Transaction (OT) award mechanism. The process includes three phases: full technical proposal submission, capabilities demonstration (by invitation), and negotiation/award (by invitation). A pre-submission webinar is scheduled for December 3, 2024, with questions due by November 25, 2024. Letters of Intent are requested by December 9, 2024 at 10:00 AM EST.