Purchase of Methylation Custom Probes for sequencing

The National Institutes of Health National Institute of Environmental Health Sciences seeks to purchase Methylation Custom Probes for DNA sequencing research on a non-competitive basis, with responses due July 21, 2026. The procurement is a commercial items acquisition under FAR 12.603, with TWIST BIOSCIENCE identified as the intended awardee.

Place of performance is Durham, NC (111 TW Alexander Drive, Research Triangle Park, NC 27709). The requirement supports epigenetics, mitochondrial biology, and metabolism research within the Mechanistic Toxicology Branch. The custom probes must enable flexible, customizable panel design for highly targeted interrogation of DNA methylation patterns, with particular emphasis on rat genome methylation analysis where commercially available solutions are limited or unavailable. The NAICS code is 541714, Research and Development in Biotechnology; the PSC code is Q301, Reference Laboratory Testing.

Offerors must be actively registered in SAM and provide UEI, TIN, and business size certification. Price quotations must include unit price, list price, shipping and handling costs, delivery timeframe, delivery terms, prompt payment discount terms, F.O.B. point, and product or catalog numbers. Respondents offering brand-name products must provide product documentation demonstrating compliance with required characteristics, quantity, estimated price, shipping and handling charges, and delivery timeframe. Evaluation factors include past performance, technical capability, special features, warranty, maintenance availability, and environmental considerations. This acquisition is not expected to exceed the simplified acquisition threshold and does not fall under the Defense Priorities and Allocations System.