Notice of Intent to Sole Source - Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB)
Closed Special Notice Posted
- Solicitation number
- 75N93024R00022
- Agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Place of performance
- Rockville, Maryland 20852, United States
Notice details come from SAM.gov. Updated .
About this opportunity
The National Institute of Allergy and Infectious Diseases (NIAID) announced a sole-source intent on April 9, 2026, to continue the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) contract, with a proposal deadline of May 15, 2026. Despite the sole-source justification supporting RTI International based on unique technical capabilities and substantial switching costs, the solicitation (75N93024R00022) remains open to any responsible offeror.
The contract funds design, synthesis, in vitro testing, and distribution of chemical libraries targeting Gram-negative bacterial pathogens and antibiotic-resistant bacteria. Work occurs across four key areas: Library Design, Compound Synthesis, Compound Testing, and Compound Management, with integrated Project Management. The base performance period runs February 1, 2027 through January 31, 2028, with six one-year option periods extending through January 31, 2034. Offerors must test 1,640 compounds annually and submit technical proposals limited to 75 pages. This is a Firm-Fixed-Price contract; labor is fixed at 5,000 hours for the base and options A1–A4, 2,500 hours for options A5–A7. Travel may not be included in pricing.
Proposals are submitted electronically via the NIAID eCPS website only. Amendment 0002 was issued May 7, 2026; offerors must acknowledge receipt on their proposal or risk rejection. The estimated total cost is $28 million over the full performance period (NAICS 541714; PSC AN12). Contracting Officer: Ignacio Reyes, ignacio.reyes@nih.gov, 301-435-7574.
Notice text
The aim of this solicitation is to continue the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) responsible for coordinating and conducting the design, synthesis, in vitro testing, and distribution of chemical libraries of discrete natural products and small-molecules with diverse physicochemical properties, specifically designed to target Gram-negative bacterial pathogens and other antibiotic-resistant bacteria identified as Antimicrobial Resistance threats. The contract shall consist of requirements in four (4) key areas: 1) Library Design, 2) Compound Synthesis, 3) Compound Testing, and 4) Compound Management, and includes Project Management of all efforts across these requirements.
Any responsible offeror may submit a proposal which will be considered by the Agency. This RFP will be available electronically on April 08, 2026, and may be accessed through https://sam.gov/.
Please note: After opening/downloading the solicitation in the Chrome browser, click the down arrow and select "Open with system viewer" to view the RFP in Adobe Acrobat. This process will allow the links in Section J of the RFP to work properly.
This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted.
For this solicitation, the NIAID requires proposals to be submitted online via the NIAID electronic Contract Proposal Submission (eCPS) website. Submission of proposals by facsimile or e-mail is not acceptable.
For directions on using eCPS, go to the website https://ecps.nih.gov/ and then click on "How to Submit."
Files
| File | Type | Posted |
|---|---|---|
| Amendment No. 0002-signed.pdf | ||
| Amendment No. 0001-Signed.pdf | ||
| CC4CARB JA SAM Posting.pdf | ||
| 75N93024R00022- Signed.pdf |
Notice history
| Notice | Type | Posted |
|---|---|---|
| This notice | Special Notice | |
| Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) | Solicitation | |
| Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) | Pre-Solicitation |
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