Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB)
Closed Solicitation Posted
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- Solicitation number
- 75N93024R00022
- Agency
-
National Institute of Allergy and Infectious Diseases
National Institutes of Health, Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- 541714 Research and Development in Biotechnology (except Nanobiotechnology)
- Place of performance
- Rockville, Maryland 20852, United States
Notice details come from SAM.gov. Updated .
About this opportunity
The National Institute of Allergy and Infectious Diseases (NIAID), under the Department of Health and Human Services, is soliciting proposals for the continuation of the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB), a fixed-price research and development contract focused on designing, synthesizing, testing, and distributing chemical libraries targeting Gram-negative bacterial pathogens and other antibiotic-resistant bacteria. The contractor must execute work across four key areas: library design, compound synthesis, compound testing, and compound management, with comprehensive project management oversight. Proposals will be evaluated on a 100-point scale consisting of technical plan and approach (50 points), technical personnel evaluation (20 points), project management plan (20 points), and facilities and resources assessment (10 points). The solicitation was posted on April 8, 2026, with proposals due by May 8, 2026, and must be submitted exclusively through the NIAID electronic Contract Proposal Submission (eCPS) website; facsimile and email submissions are not acceptable. This is an unrestricted solicitation with no small business set-aside.
The contract carries no set-aside designation and is open to any responsible offeror. The base performance period extends from February 1, 2027 through January 31, 2028, with six one-year option periods available through January 31, 2034, representing a potential seven-year engagement. The contractor will be required to produce approximately 80 compounds per library with associated Minimum Inhibitory Concentration (MIC) panel testing and deliver regular technical reports including Individual Library Production Plans, synthesis reports, testing reports, and monthly and annual progress reports. The work is classified under NAICS code 541714 (Research and Development in Biotechnology) with a 1,000-employee small business size standard. Performance will take place in North Bethesda, Maryland 20852.
Notice text
The aim of this solicitation is to continue the Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) responsible for coordinating and conducting the design, synthesis, in vitro testing, and distribution of chemical libraries of discrete natural products and small-molecules with diverse physicochemical properties, specifically designed to target Gram-negative bacterial pathogens and other antibiotic-resistant bacteria identified as Antimicrobial Resistance threats. The contract shall consist of requirements in four (4) key areas: 1) Library Design, 2) Compound Synthesis, 3) Compound Testing, and 4) Compound Management, and includes Project Management of all efforts across these requirements.
Any responsible offeror may submit a proposal which will be considered by the Agency. This RFP will be available electronically on April 08, 2026, and may be accessed through https://sam.gov/.
Please note: After opening/downloading the solicitation in the Chrome browser, click the down arrow and select "Open with system viewer" to view the RFP in Adobe Acrobat. This process will allow the links in Section J of the RFP to work properly.
This notice does not commit the Government to award a contract. No collect calls will be accepted. No facsimile transmissions will be accepted.
For this solicitation, the NIAID requires proposals to be submitted online via the NIAID electronic Contract Proposal Submission (eCPS) website. Submission of proposals by facsimile or e-mail is not acceptable.
For directions on using eCPS, go to the website https://ecps.nih.gov/ and then click on "How to Submit."
Files
| File | Type | Posted |
|---|---|---|
| 75N93024R00022- Signed.pdf |
Notice history
| Notice | Type | Posted |
|---|---|---|
| Notice of Intent to Sole Source - Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) | Special Notice | |
| This notice | Solicitation | |
| Chemistry Center for Combating Antibiotic-Resistant Bacteria (CC4CARB) | Pre-Solicitation |
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