methylhydrazine.pdf

Aldrich - M50001 Page 1 of 11

The life science business of Merck KGaA, Darmstadt, Germany operates as MilliporeSigma in the US and Canada

SAFETY DATA SHEET

Version 6.3 Revision Date 09/26/2020

Print Date 11/20/2020

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers

Product name : Methylhydrazine

Product Number : M50001

Brand : Aldrich

CAS-No. : 60-34-4

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses : Laboratory chemicals, Synthesis of substances

1.3 Details of the supplier of the safety data sheet

Company : Sigma-Aldrich Inc.

3050 Spruce Street

ST. LOUIS MO 63103

UNITED STATES

Telephone : +1 314 771-5765

Fax : +1 800 325-5052

1.4 Emergency telephone

Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-

527-3887 CHEMTREC (International) 24

Hours/day; 7 Days/week

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture

GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)

Flammable liquids (Category 2), H225

Acute toxicity, Oral (Category 2), H300

Acute toxicity, Inhalation (Category 1), H330

Acute toxicity, Dermal (Category 2), H310

Skin corrosion (Category 1B), H314

Serious eye damage (Category 1), H318

Carcinogenicity (Category 1B), H350

Short-term (acute) aquatic hazard (Category 1), H400

Long-term (chronic) aquatic hazard (Category 1), H410

For the full text of the H-Statements mentioned in this Section, see Section 16.

2.2 GHS Label elements, including precautionary statements

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Pictogram

Signal word Danger

Hazard statement(s)

H225 Highly flammable liquid and vapor.

H300 + H310 + H330 Fatal if swallowed, in contact with skin or if inhaled.

H314 Causes severe skin burns and eye damage.

H350 May cause cancer.

H410 Very toxic to aquatic life with long lasting effects.

Precautionary statement(s)

P201 Obtain special instructions before use.

P202 Do not handle until all safety precautions have been read and understood.

P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No smoking.

P233 Keep container tightly closed.

P240 Ground/bond container and receiving equipment.

P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.

P242 Use only non-sparking tools.

P243 Take precautionary measures against static discharge.

P260 Do not breathe dust/ fume/ gas/ mist/ vapors/ spray.

P262 Do not get in eyes, on skin, or on clothing.

P264 Wash skin thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

P271 Use only outdoors or in a well-ventilated area.

P273 Avoid release to the environment.

P280 Wear protective gloves/ protective clothing/ eye protection/ face protection.

P284 Wear respiratory protection.

P301 + P310 + P330 IF SWALLOWED: Immediately call a POISON CENTER/ doctor.

Rinse mouth.

P301 + P330 + P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P302 + P350 + P310 IF ON SKIN: Gently wash with plenty of soap and water.

Immediately call a POISON CENTER or doctor/ physician.

P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.

P304 + P340 + P310 IF INHALED: Remove person to fresh air and keep comfortable for breathing. Immediately call a POISON CENTER/ doctor.

P305 + P351 + P338 +

P310

IF IN EYES: Rinse cautiously with water for several minutes.

Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER/ doctor.

P308 + P313 IF exposed or concerned: Get medical advice/ attention.

P362 Take off contaminated clothing and wash before reuse.

P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant foam to extinguish.

P391 Collect spillage.

P403 + P233 Store in a well-ventilated place. Keep container tightly closed.

P403 + P235 Store in a well-ventilated place. Keep cool.

P405 Store locked up.

P501 Dispose of contents/ container to an approved waste disposal plant.

2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none

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SECTION 3: Composition/information on ingredients

3.1 Substances

Formula : CH6N2

Molecular weight : 46.07 g/mol

CAS-No. : 60-34-4

EC-No. : 200-471-4

Component Classification Concentration methylhydrazine

Flam. Liq. 2; Acute Tox. 2;

Acute Tox. 1; Acute Tox.

2; Skin Corr. 1B; Eye

Dam. 1; Carc. 1B; Aquatic

Acute 1; Aquatic Chronic

1; H225, H300, H330, H310, H314, H318, H350, H400, H410

M-Factor - Aquatic Acute:

M-Factor - Aquatic

Chronic: 10

<= 100 %

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures

General advice

Consult a physician. Show this material safety data sheet to the doctor in attendance.Move out of dangerous area.

If inhaled

If breathed in, move person into fresh air. If not breathing, give artificial respiration.

Consult a physician.

In case of skin contact

Take off contaminated clothing and shoes immediately. Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.

In case of eye contact

Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.Continue rinsing eyes during transport to hospital.

If swallowed

Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

4.2 Most important symptoms and effects, both acute and delayed

The most important known symptoms and effects are described in the labelling (see section

2.2) and/or in section 11

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4.3 Indication of any immediate medical attention and special treatment needed

No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media

Suitable extinguishing media

Dry powder Dry sand

Unsuitable extinguishing media

Do NOT use water jet.

5.2 Special hazards arising from the substance or mixture

Carbon oxides, Nitrogen oxides (NOx)

5.3 Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

5.4 Further information

Use water spray to cool unopened containers.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures

Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas.

For personal protection see section 8.

6.2 Environmental precautions

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Discharge into the environment must be avoided.

6.3 Methods and materials for containment and cleaning up

Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations (see section 13).

6.4 Reference to other sections

For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling

Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.

Use explosion-proof equipment.Keep away from sources of ignition - No smoking.Take measures to prevent the build up of electrostatic charge.

For precautions see section 2.2.

7.2 Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

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Air sensitive. hygroscopic Handle and store under inert gas.

Storage class (TRGS 510): 3: Flammable liquids

7.3 Specific end use(s)

Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection

8.1 Control parameters

Ingredients with workplace control parameters

Component CAS-No. Value Control parameters

Basis methylhydrazine

60-34-4

TWA 0.01 ppm

USA. ACGIH Threshold Limit

Values (TLV)

Remarks Upper Respiratory Tract irritation

Eye irritation

Liver damage

Lung cancer

Confirmed animal carcinogen with unknown relevance to humans

Danger of cutaneous absorption C 0.04 ppm

0.08 mg/m3

USA. NIOSH Recommended

Exposure Limits Potential Occupational Carcinogen

See Appendix A

2 hour ceiling value C 0.2 ppm

0.35 mg/m3

USA. Occupational Exposure

Limits (OSHA) - Table Z-1

Limits for Air Contaminants Skin designation

The value in mg/m3 is approximate.

Ceiling limit is to be determined from breathing-zone air samples.

PEL 0.01 ppm

0.019 mg/m3

California permissible exposure limits for chemical contaminants (Title 8, Article

107) Skin

Biological occupational exposure limits

Component CAS-No. Parameters Value Biological specimen

Basis

Methemoglo bin

1.5% Hb In blood ACGIH -

Biological

Exposure Indices

(BEI)

Remarks During or at the end of the shift

8.2 Exposure controls

Appropriate engineering controls

Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product.

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Personal protective equipment

Eye/face protection

Tightly fitting safety goggles. Faceshield (8-inch minimum). Use equipment for eye protection tested and approved under appropriate government standards such as

NIOSH (US) or EN 166(EU).

Skin protection

Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Splash contact

Material: butyl-rubber

Minimum layer thickness: 0.3 mm

Break through time: 74 min

Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail sales@kcl.de, test method: EN374

If used in solution, or mixed with other substances, and under conditions which differ from EN 374, contact the supplier of the EC approved gloves. This recommendation is advisory only and must be evaluated by an industrial hygienist and safety officer familiar with the specific situation of anticipated use by our customers. It should not be construed as offering an approval for any specific use scenario.

Body Protection

Complete suit protecting against chemicals, Flame retardant antistatic protective clothing., The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Respiratory protection

Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as

NIOSH (US) or CEN (EU).

Control of environmental exposure

Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Discharge into the environment must be avoided.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties

a) Appearance Form: liquid

b) Odor No data available

c) Odor Threshold No data available

d) pH No data available

e) Melting point/freezing point

Melting point/freezing point: -52.4 °C (-62.3 °F)

f) Initial boiling point 88 - 90 °C 190 - 194 °F - lit.

Aldrich - M50001 Page 7 of 11 and boiling range

g) Flash point -8 °C (18 °F) - closed cup

h) Evaporation rate No data available

i) Flammability (solid, gas)

No data available

j) Upper/lower flammability or explosive limits

Upper explosion limit: 97 %(V)

Lower explosion limit: 2.5 %(V)

k) Vapor pressure 67 hPa at 25 °C (77 °F)

66.5 hPa at 25 °C(77 °F)

l) Vapor density 1.59 - (Air = 1.0)

m) Relative density 0.875 g/cm3 at 20 °C (68 °F)

n) Water solubility 1,000 g/l at 25 °C (77 °F)1,000 g/l at 25 °C (77 °F) - soluble

o) Partition coefficient:

n-octanol/water log Pow: -1.05

p) Autoignition temperature

182 °C (360 °F) at 980 hPa

q) Decomposition temperature

No data available

r) Viscosity No data available

s) Explosive properties No data available

t) Oxidizing properties No data available

9.2 Other safety information

Surface tension 33.83 mN/m

Relative vapor density

1.59 - (Air = 1.0)

SECTION 10: Stability and reactivity

10.1 Reactivity

No data available

10.2 Chemical stability

Stable under recommended storage conditions.

10.3 Possibility of hazardous reactions

Vapors may form explosive mixture with air.

10.4 Conditions to avoid

Heat, flames and sparks.

10.5 Incompatible materials

Oxidizing agents, Oxygen, Peroxides

10.6 Hazardous decomposition products

Hazardous decomposition products formed under fire conditions. - Carbon oxides, Nitrogen oxides (NOx)

Other decomposition products - No data available

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In the event of fire: see section 5

SECTION 11: Toxicological information

11.1 Information on toxicological effects

Acute toxicity

LD50 Oral - Rat - 32 mg/kg

Remarks: Behavioral:Convulsions or effect on seizure threshold.

LC50 Inhalation - Rat - 4 h - 34 ppm

LD50 Dermal - Rabbit - 95 mg/kg

Remarks: Blood:Methemoglobinemia-Carboxyhemoglobin.

No data available

Skin corrosion/irritation

No data available

Serious eye damage/eye irritation

No data available

Respiratory or skin sensitization

No data available

Germ cell mutagenicity

Mouse lymphocyte

Result: negative

OECD Test Guideline 478

Rat - male

Result: negative

Carcinogenicity

This product is or contains a component that has been reported to be possibly carcinogenic based on its IARC, ACGIH, NTP, or EPA classification.

Possible human carcinogen

IARC: No ingredient of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.

NTP: No ingredient of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.

OSHA: No component of this product present at levels greater than or equal to 0.1% is on OSHA’s list of regulated carcinogens.

Reproductive toxicity

No data available

No data available

Specific target organ toxicity - single exposure

No data available

Specific target organ toxicity - repeated exposure

No data available

Aspiration hazard

No data available

Additional Information

RTECS: MV5600000

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Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., Cough, Shortness of breath, Headache, Nausea

SECTION 12: Ecological information

12.1 Toxicity

Toxicity to fish static test LC50 - Ictalurus punctatus - 2.27 mg/l - 96 h

Remarks: (ECHA)

Toxicity to daphnia and other aquatic invertebrates

Immobilization EC50 - Daphnia magna (Water flea) - 0.04 mg/l - 48 h

(OECD Test Guideline 202)

Toxicity to algae Growth inhibition EC50 - Pseudokirchneriella subcapitata - < 0.02 mg/l - 72 h

(OECD Test Guideline 201)

12.2 Persistence and degradability

Biodegradability aerobic Chemical oxygen demand - Exposure time 28 d

Result: 44.9 % - Not readily biodegradable.

(OECD Test Guideline 301D)

12.3 Bioaccumulative potential

No data available

12.4 Mobility in soil

No data available

12.5 Results of PBT and vPvB assessment

PBT/vPvB assessment not available as chemical safety assessment not required/not conducted

12.6 Other adverse effects

Very toxic to aquatic life with long lasting effects.

An environmental hazard cannot be excluded in the event of unprofessional handling or disposal.

No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods

Product

Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.

Contaminated packaging

Dispose of as unused product.

Aldrich - M50001 Page 10 of 11

SECTION 14: Transport information

DOT (US)

UN number: 1244 Class: 6.1I (3, 8) Packing group: I

Proper shipping name: Methylhydrazine

Reportable Quantity (RQ): 10 lbs

Poison Inhalation Hazard: Hazard Zone A

IMDG

UN number: 1244 Class: 6.1 (3, 8) Packing group: I EMS-No: F-E, S-C

Proper shipping name: METHYLHYDRAZINE

Marine pollutant : yes

IATA

UN number: 1244 Class: 6.1 (3, 8)

Proper shipping name: Methylhydrazine

IATA Passenger: Not permitted for transport

IATA Cargo: Not permitted for transport

SECTION 15: Regulatory information

SARA 302 Components

CAS-No.

Revision Date

2013-02-08

SARA 313 Components

The following components are subject to reporting levels established by SARA Title III, Section 313:

CAS-No.

SARA 311/312 Hazards

Fire Hazard, Acute Health Hazard, Chronic Health Hazard

Massachusetts Right To Know Components

No components are subject to the Massachusetts Right to Know Act.

Pennsylvania Right To Know Components methylhydrazine CAS-No.

SECTION 16: Other information

Further information

Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only.

The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of

Aldrich - M50001 Page 11 of 11 the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

The branding on the header and/or footer of this document may temporarily not visually match the product purchased as we transition our branding. However, all of the information in the document regarding the product remains unchanged and matches the product ordered. For further information please contact mlsbranding@sial.com.

Version: 6.3 Revision Date: 09/26/2020 Print Date: 11/20/2020