Attachment_E_Task_Description_Document_HUBBLE.docx

30 KB Posted

Attached to
High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)
Solicitation number
DARPA-PA-27-01
Issued by

About this file

Written by GovTribe AI ·

This is a Task Description Document for the HUBBLE (High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators) program solicited by the Defense Advanced Research Projects Agency (DARPA) under solicitation number DARPA-PA-27-01.

The document outlines DARPA's requirement to develop an in-silico capability for comprehensively mapping protein-protein interactions across biological systems. The primary objective is to create computational tools and models that can predict and characterize the full landscape of protein binding interactions. The developed capability will be validated and demonstrated through application to traumatic brain injury research, with the goal of identifying novel diagnostic and therapeutic targets within the protein interaction space relevant to TBI pathology. Proposers are expected to deliver advanced computational methodologies, validated models, and documented results demonstrating the effectiveness of their approach in mapping biological interactomes and translating these findings into actionable clinical targets.

View the file

Other files

File Type Posted
Attachment_D_Schedule_Milestone_and_Payments.xlsx XLSX spreadsheet
Attachment_A_Abstract_Template_and_Instructions__Phase_1_.docx DOCX document
Attachment_F_Risk_Matrix_HUBBLE.pptx PPTX presentation
DARPA-PA-27-01.pdf PDF
Attachment_B_DARPA-PA-26-10__Model_OT_for_Research_HUBBLE_20261008.docx DOCX document
Attachment_C_Cost_Proposal_Spreadsheet_HUBBLE.xlsx XLSX spreadsheet

On GovTribe

Work with this file

  • Download the original file
  • Contacts named in this file
  • Similar government files
  • Ask GovTribe AI about this file
Try for free Login

Text version

The file's text, extracted by GovTribe without its formatting.

Attachment E: DARPA-PA-27-01 Task Description Document Competition Sensitive DARPA-PA-27-01: High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

TASK DESCRIPTION DOCUMENT (TDD)

[It is recommended to submit the TDD as this separate HUBBLE Attachment E file]

[For an OT, the TDD is binding and documents what will be accomplished in the project.

Instructions: Use of this template and the Example 1 table below is required. This document should break down the proposed research plan into specific tasks and subtasks and provide concise statements of the objective(s), tasks, metrics, milestones, and deliverables. These tasks/subtasks should lead to the technical milestones outlined in HUBBLE Attachment D “Schedule of Milestones and Payments” (also Attachment 3 in the Model-OT).

There is no page limit to this template. Instructional (blue) and example (in the table below) text should be deleted. Not all tasks require subtasks. Do not include proprietary information.

For each defined task/subtask, provide:

· A general description of the objective.

· A detailed description of the approach to be taken to accomplish each defined task/subtask.

· Identification of any tasks/subtasks that will involve human subjects or animals.

· Identification of any tasks/subtasks that will be performed on campus at a university.

· Identification (by name) of the primary organization (prime contractor, subawardee(s), consultant(s)) responsible for task/subtask execution.

· Measurable milestones (e.g., a metric, deliverable, demonstration, or other event/activity that marks task progress or completion).

· A definition of all deliverables (e.g., data, reports, software) to be provided to the Government in support of the proposed tasks/subtasks.]

The objective of this proposal is: [Insert a general description of the objective.]

[Example 1: TDD Task Table] Task 1 Peanut butter and jelly (PBJ) sandwich [Month 1 – Month 4]

Lead:
Pepperidge Farm
Support:
Jif and Smuckers
Location:
Pepperidge Farm laboratory, Jif laboratory, Smuckers laboratory
Description:
Development of a sandwich, consisting of both peanut butter and jelly. Application of both compounds will be optimized on two different substrates, with and without crust, and will then be used to demonstrate an integrated meal at a lunchtime panel. Final metrics will evaluate ease (i.e. time required for completion), uniformity, and reproducibility.

Subtask 1.1 Optimize peanut butter application [Month 1 – Month 4]

Lead:
Jif
Support:
Pepperidge Farm
Location:
Jif laboratory, Pepperidge Farm laboratory
Description:
To evaluate the effect of peanut butter consistency on overall PBJ quality, we will design and execute a suite of experiments to test different peanut butters with a standard piece of whole wheat bread. Initial exploratory experiments will establish the effects of volume of material to be spread, spreading utensil, and spreading technique. Final metrics will evaluate ease and uniformity of application, and reproducibility across at least 3 replicates.
Milestones:
· Finalize protocol based on initial exploratory experiments (Month 1)

· Complete testing of different peanut butter consistencies ranging from smooth to chunky (Month 2)

Deliverables:
· Report with data summarizing the results of peanut butter optimization experiments and optimized protocol (Month 2)

Subtask 1.2 Optimize jelly [Month 1 – Month 2]

Lead:
Smuckers
Support:
Pepperidge Farm
Location:
Smuckers laboratory, Pepperidge Farm laboratory
Description:
To evaluate the effect of jelly consistency on overall PBJ quality, we will design and execute a suite of experiments to test different jellies with a standard piece of whole wheat bread. Initial exploratory experiments will establish the effects of volume of material to be spread, spreading utensil, and spreading technique. Final metrics will evaluate ease and uniformity of application, and reproducibility across at least 3 replicates.
Milestones:
· Finalize protocol based on initial exploratory experiments (Month 1)

· Complete testing of different jelly consistencies ranging from jam to preserves (Month 2)

Deliverables:
· Report with data summarizing the results of jelly optimization experiments and optimized protocol (Month 2)

Subtask 1.3 Integration and demonstration of optimal PBJ [Month 2 – Month 4]

Lead:
Pepperidge Farm
Support:
Jif and Smuckers
Location:
Pepperidge Farm laboratory, Jif laboratory, Smuckers laboratory
Description:
Evaluation of the optimal PBJ will require integration of sub-tasks 1.1 and 1.2. Teams will share materials, methods, and protocols, and establish interoperability between laboratories. An assembly protocol will be developed to facilitate the consistent stacking of each piece of bread (one slice peanut butter, one slice jelly), with the covered surfaces facing each other, and edges of the bread aligned to the maximum extent possible. Versions will be prepared with and without crusts. The task will culminate in a demonstration using a panel of 3 hungry children who will score the PBJs using a rubric developed as part of this task.
Milestones:
· Establish interoperability between peanut butter laboratory and jelly laboratory (Month 2)

· Finalize protocol for PBJ assembly (Month 2.5)

· Finalize scoring rubric for taste-testing (Month 2.5)

Deliverables:
· Host demonstration including panel of taste-testers for evaluating final PBJ, with and without crusts (Month 3)

· Final Report summarizing results of Demonstration, including data from scoring rubric (Month 4)

File details come from the government source that posted it. Updated .