Attachment_D_Schedule_Milestone_and_Payments.xlsx
XLSX spreadsheet 28 KB Posted
- Attached to
- High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)
- Solicitation number
- DARPA-PA-27-01
About this file
This is a milestone and payment schedule template for the DARPA HUBBLE (High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators) solicitation (DARPA-PA-27-01), which seeks to develop in-silico capabilities for mapping protein-protein interactions with applications to traumatic brain injury diagnostics and therapeutics.
Proposers must complete this schedule identifying key measurable milestones, corresponding due dates, deliverables, and associated costs throughout the period of performance. The template establishes minimum requirements including a kickoff meeting in Month 1 after agreement award, mid-phase PI meeting in Month 6, and end-of-phase benchmarking in Month 11-12. Critical Phase 1 metrics include establishing proof-of-concept predictions for protein complexes with greater than 5 interactors (Month 6), delivering PPI predictions to the Government team for validation (Month 8), achieving interactor prediction accuracy greater than 90% (Month 11), and generating predictions across more than 10 unique contexts including cell types, perturbations, timepoints, and disease states (Month 12). Proposers must develop additional milestones aligned to their technical approach and task description documents. Payment structures must reflect actual comprehensive costs specific to each milestone rather than equal allocations, with no advance payments permitted. Deliverable descriptions must be substantive and quantitatively measurable, demonstrating demonstrable completion through specific metrics and exit criteria rather than generic status reports.
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Other files
| File | Type | Posted |
|---|---|---|
| Attachment_A_Abstract_Template_and_Instructions__Phase_1_.docx | DOCX document | |
| Attachment_E_Task_Description_Document_HUBBLE.docx | DOCX document | |
| Attachment_F_Risk_Matrix_HUBBLE.pptx | PPTX presentation | |
| DARPA-PA-27-01.pdf | ||
| Attachment_B_DARPA-PA-26-10__Model_OT_for_Research_HUBBLE_20261008.docx | DOCX document | |
| Attachment_C_Cost_Proposal_Spreadsheet_HUBBLE.xlsx | XLSX spreadsheet |
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Text version
Milestones instructions Please complete this schedule of milestones and payments spreadsheet for all OT Agreement. This should contain information about proposed milestones, due dates, deliverables, and payments associated. The results from payable milestones will be used for strategic planning and/or inform programmatic decision. At a minimum, key critical milestones must be included for the proposed effort. Tasks and targets should be keyed to the Task Description Document. Note that "AAA" denotes "after agreementt award", and the highlighted sections are not to be filled out by proposers.
Helpful notes for Milestones:
• Each milestone will mark the completion of a measurable event (i.e., completing a baseline execution plan, completing measurable events in the performance of the research and development of the technology, completing and submitting the final report, etc.).
• Deliverable narrative should provide description of what is being delivered, the word “Report” is not sufficient. “Status/Progress/Reports” cannot be milestones.
• The milestone description will show how the milestone will be demonstrably completed.
• Payments associated with each milestone must reflect the actual comprehensive costs to achieve milestone completion. (Note do not take total cost and divide by number of milestones)
• Although this is a R&D effort the amounts against each milestone should NOT be the same. consider what actually goes into the pricing of that particular milestone as each milestone should have its own cost. (If amounts remain the same, please clearly expand the deliverable description)
• The milestones need to be more definitive and consider what actually goes into the pricing of that particular milestone.
• The milestone description will show how the milestone will be demonstrably completed.
• No advance payments on milestones
Three Milestone Examples:
| • | Kickoff Meeting presentation including project design, acquisition of equipment, and overall workflow leading to accomplishment of deliverables. Kickoff briefing package will include team organization, technical approach and research goals, expected results and schedule, and risk and mitigation strategies |
| • | Kick-off meeting presentation with description of proposed effort to include the description of proposed concept, focus area and potential application domain; Justification of proposed approach based on preliminary analyses or modeling; Justification of the benefits of the proposed scheme in achieving beyond-XXX performance in the potential application domain; Description and preliminary analyses of the proposed concept metrics that will be achieved during the period of performance, and comparison of these metrics to the current XXX. All supporting positions identified in the proposal are assigned to personnel, and names are provided to the Government. Order materials and equipment. |
| • | Design XXXX molecule candidate(s) and investigate simulated molecular conformation changes induced by the onset and offset of near infrared (NIR) light in the range of 750 nm to 900 nm, as well as simulated binding to target protein(s) of interest in the presence of NIR light. METRIC: XXXX candidates demonstrate molecular conformation change in the presence of NIR light in the range of XXX to XXX nm, and bind to target protein(s) of interest in the presence of NIR light in a simulated environment. |
Two Exit Criteria Examples:
• Submit kickoff meeting charts and Initial Test Plan
• Submit Milestone report describing design approach and molecular structure(s) of XXXX and simulation results.
Milestone and Payment Schedule
| 3 | ||||
| Milestone # | Milestones (Description) | Exit Criteria/Deliverable | Due | |
| Date | Payment | Funded | CLIN | |
| SUBCLIN | ACRN | |||
| … This is a suggested schedule of milestones. Propose your own as needed … | ||||
| 1 | Kickoff Meeting: A briefing on the technical plan for the effort to include milestone schedule and path to accomplish the objectives of the agreement. | |||
| • Kickoff meeting briefing slides that is acceptable to DARPA. | Month 1 After Agreement Award (AAA) | |||
| 2 | Proposer defined milestones towards end of Phase Goals | Quantitative metric that demonstrates progress towards Program metrics | ||
| 3 | Proposer defined milestones towards end of Phase Goals | ^ | ||
| 4 | Proposer defined milestones towards end of Phase Goals | ^ | ||
| 5 | Proposer defined milestones towards end of Phase Goals | ^ | ||
| 6 | Establish proof of concept prediction for protein complex with > 5 interactors | ref: Figure 6. Phase 1 metrics table | Proposer defined | |
| 7 | Mid Phase PI meeting | Attend an in person meeting and provide technical update to the program participants and stakeholders | Month 6 | |
| 8 | TBI Associated PPI predictions delivered to Government team for Validation | ref: Figure 6. Phase 1 metrics table | Month 8 | |
| 9 | Proposer defined milestones towards end of Phase Goals | ^ | ||
| 10 | Proposer defined milestones towards end of Phase Goals | ^ | ||
| 11 | End of Phase Benchmarking Task: Generalized predictions compared to Government team test set. | Phase 1 PPI accuracy metrics achieved (Interactor predictions >90%) | Month 11 | |
| 12 | PPI predictions made across >10 unique contexts (cell types, perturbations, timepoints, diseases states, etc.) | ref: Figure 6. Phase 1 metrics table | Month 12 |
| 1 | … Propose your own as needed … | ||
| Total Agreement | $ - 0 | $ - 0 | |
| *Tasks and targets are keyed to Task Description Document | |||
| HIGHLIGHTED SECTION NOT TO BE FILLED OUT BY PROPOSERS |
Attachment 3 - Schedule of Milestones and Payments
File details come from the government source that posted it. Updated .