Attachment 7 - Sample Task Order C-01.pdf

ATTACHMENT 7: SAMPLE TASK ORDER ASSOCIATED WITH TASK AREA C: PARASITES

AND VECTORS

IN VITRO ASSESSMENTS OF ANTIMICROBIAL ACTIVITY

SAMPLE TASK ORDER C01

“Determination of In Vitro Efficacy of Antiparasitic Candidates or Vector Repellents”

NOTE: Offerors proposing for Task Area C must include in their proposal a response to the following sample task order: C01. There is no added value in submitting multiple proposals in a single Task Area. The Offeror should be encouraged to submit its best proposal – i.e., the one for which it has the highest qualifications and capabilities.

Offerors proposing for Task Area C must submit a proposal that includes information pertaining to Task Area C only.

The following Sample Task Order is provided to assess the Offeror’s capabilities to conduct and fulfill the requirements of the Statement of Work for projects of similar scope and size to be issued under contracts awarded in response to this solicitation. Although this Sample Task Order will NOT be awarded, Offerors are to include in their proposals a response that specifies the methods by which the Sample Task Order would be accomplished and include an associated budget. Offerors should refer to the Additional Technical Proposal Instructions and Additional Business Proposal Instructions for guidance regarding preparation of their proposals.

SECTION B – SUPPLIES OR SERVICES AND PRICES/COSTS

1. PRICES

This is a firm-fixed price type task order.

SECTION C – DESCRIPTION/SPECIFICATIONS/WORK STATEMENT

Statement of Work

I. SCOPE

Determination of in vitro Parasite Growth Inhibition or Vector Repellency of candidate anti-parasitic or anti-vector test articles.

Note: Offerors should select either anti-parasitic or anti-vector in the sample task order scope statement and prepare the response using a parasite or vector from Table 1.

II. TECHNICAL REQUIREMENTS

Independently, and not as an agent of the Government, the Contractor shall furnish all the necessary services, qualified personnel, materials, equipment, and facilities, not otherwise provided by the Government as needed to perform the Statement of Work below.

The requirements for Task Area C defined in the base Statement of Work apply to all work performed under this Task Order.

In addition to the requirements laid out in the base Statement of Work, the Contractor shall conduct the following testing:

1. Parasite Growth Inhibition or Vector Repellency Testing

a. The Contractor shall store and maintain of all candidate test articles provided to the Contractor by the Government or through a third-party under conditions specified by the COR.

b. The Contractor shall evaluate twenty (20) candidate test articles performing a dose-response curve to determine the 50% inhibitory concentration of parasite growth in culture or repellency of live vector, selecting a parasite or vector species from Table 1 below.

[For purposes of this Sample Task Order, one evaluation is defined as one parasite strain or vector species-test compound combination, with appropriate controls.]

Table 1 – Parasites and Vectors

Parasites Vectors

Apicomplexa Black flies Babesia Lice Cryptosporidium Mosquitos Toxoplasma Sand flies Entamoeba spp. Snails Filarial worms Ticks Leishmania spp. Triatomine bugs Plasmodium falciparum Tse tse flies Plasmodium spp.

Schistosoma spp.

Trypanosoma spp.

c. For antiparasitic evaluations, the Contractor shall perform tests in triplicate and shall include an appropriate first line therapy as a comparator.

d. For repellency evaluations the Contractor shall perform 5 replicates of 10 insects per treatment and shall include an approved repellent as a comparator.

e. The Contractor shall complete testing within 30 days of receipt of test articles.

f. The Contractor shall perform all determinations for each candidate test article in accordance with the reporting requirements described herein.

2. Communication and Reporting

a. The Contractor shall conduct monthly teleconference calls with the COR to report on progress and provide minutes of each teleconference in accordance with the Reporting Requirements and Delivery Schedule.

b. The Contractor shall provide a Final Report in accordance with the Reporting Requirements and Delivery Schedule.

SECTION D – PACKAGING, MARKING, AND SHIPPING

There are no additional D. clauses applicable to this Task Order beyond those in the base contract.

SECTION E – INSPECTION AND ACCEPTANCE

There are no additional E. clauses applicable to this Task Order beyond those in the base contract.

SECTION F – DELIVERIES OR PERFORMANCE

1. PERIOD OF PERFORMANCE

The period of performance for this Sample Task Order is ten (10) months.

2. TASK ORDER REPORTING REQUIREMENTS AND DELIVERABLES

Technical Reports

All reports required herein shall be submitted in electronic format.

All electronic reports submitted shall be compliant with Section 508 of the Rehabilitation Act of 1973. Additional information about testing documents for Section 508 compliance, including guidance and specific checklists, by application, can be found at:

http://www.hhs.gov/web/508/index.html under "Making Files Accessible."

1. Final Report http://www.hhs.gov/web/508/index.html

This report is to include a summation of the work performed and results obtained for the entire contract period of performance. This report shall be in sufficient detail to describe comprehensively the results achieved and shall include:

• Parasite growth inhibition or vector repellency results

• Preparation, lot number, and handling of test articles

• Parasite or Vector growth conditions

• Specific parasite or vector line used, and control anti-parasitic agents or vector repellents.

The Final Report shall be submitted in accordance with the DELIVERIES Article in SECTION F of this task order.

Other Reports and Deliverables

All reports required herein shall be submitted in electronic format.

1. Compound Test Result Reports

a. Title Page containing

i. Sample Task Order number

ii. Test Site

iii. Experiment number

iv. Test compound name

b. Type of assay with brief details on set up

i. Parasite or vector screened, including known provenance and passage details

ii. Cell line (as relevant), including known provenance, passage details, and growth conditions

iii. Vehicle used for test and control compounds

iv. Documentation of preparation of test and control compound(s)

v. Test compound concentration range

vi. Control compound name

vii. Control concentration range

c. Results

i. 50% and 90% growth inhibition

ii. Dose-response curve with error bars for test and control compound

iii. Include a brief assay narrative of any salient observations

iv. Any specific comments including description of any technical or performance problems encountered, along with proposed corrective action taken

d. Raw data in a tabular format from which the curves obtained

2. Monthly Teleconference Minutes

The Contractor shall provide and deliver, in accordance with the Delivery Schedule, minutes of the monthly teleconferences which include the following:

a. List of action items (including who is responsible for the action item).

b. Summary of any high-level decisions made during the teleconference.

c. Number of assays performed and committed to date as well as remaining number of assays.

d. Summary of concerns raised during the teleconference and the plan to address these concerns.

e. Appendix including all Compound Test Result Reports finalized during that month.

TASK ORDER DELIVERY SCHEDULE

Item Report Recipient Delivery Schedule

1. Final Report 1 electronic copy to COR and CO.

Due on/before the completion date of the task order.

2. Compound Test Result Report

1 electronic copy to COR and CO.

Due on/before 30 calendar days following completion of testing on a compound.

Compounds completed during the final 30 days of this task order shall be submitted on the expiration date of the task order

3. Monthly Teleconference Minutes

1 electronic copy to COR and CO.

On or before 7 calendar days following the teleconference

SECTION G – TASK ORDER ADMINISTRATION DATA

There are no additional G. clauses applicable to this Task Order beyond those in the base contract.

SECTION H – TASK ORDER ADMINISTRATION DATA

There are no additional H. clauses applicable to this Task Order beyond those in the base contract.