Attachment 1 - Statement of Need_Redacted.pdf
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- Attached to
- 10X Genomics Reagent Kits for NIDDK Federal contract opportunity
- Solicitation number
- 75N94025Q00181
About this file
This Statement of Need details a purchase order for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to acquire 10x Genomics reagent kits and instrument upgrades for single-cell and spatial transcriptomics research. The specific requirements include Xenium Prime and GEM-X Flex products such as 5K Mouse Pan Tissue Assays, Sample Preparation Kits, Gene Expression Kits, and a trade-up of their existing Chromium Controller to a CytAssist instrument.
The procurement is a fixed-price, delivery order with a 60-day performance period, to be delivered to the NIH NIDDK facility in Rockville, Maryland. The objective is to enable high-resolution mapping of cellular states and spatial gene expression across multiple research projects, allowing NIDDK to profile tissue resident cells and understand molecular pathways that contribute to disease development. The Project Officer will monitor technical progress, interpret work requirements, perform technical evaluations, and assist in resolving any performance issues during the contract period.
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Other files for this federal contract opportunity
| File | Type | Posted |
|---|---|---|
| SON 7249860 v2_Redacted.pdf | ||
| JA 7249860 final_Redacted.pdf | ||
| Attachment 3 - NIH Invoice and Payment Provisions.pdf | ||
| Combined Synopisis-Solicitation 75N94025Q00181.pdf | ||
| Attachment 2 - Evaluation Criteria.pdf | ||
| Attachment 4 - FAR 52.212-5 (JAN 2025) [(DEVIATION FEB 2025)] 75N94025Q00181.pdf |
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Text version
STATEMENT OF NEED
1.0 PURCHASE ORDER TITLE
10X Genomics Reagent Kits for NIDDK
2.0 BACKGROUND
The NIDDK explores how cells maintain homeostasis in various tissues of the digestive, kidney, and related systems and how that balance breaks down to drive disease. To pinpoint the molecular switches that tip systems of the body from healthy to harmful, our institute profiles tissue resident and homing cells (such as inflammatory immune cells) directly within affected tissue.
Standard bulk and microdissection spatial methods average signals across millions of cells and mask the critical differences that spark disease. The 10x Genomics single-cell and spatial kits solve this problem.
Single-cell RNA-seq tells NIDDK which genes are turned on, while spatial workflows let us pinpoint where those cells and molecules are pinpointed within tissue. Merging these readouts gives us a high-resolution atlas of gene expression across tissues and disease states with healthy controls. These data are essential for the NIDDK mission: they reveal the exact pathways that malfunction, identify new drug targets, and guide the development of precision therapies to halt or diseases of major body system organs.
3.0 OBJECTIVE
The objective of this procurement is to acquire a bundled set of 10x Genomics consumables and an instrument trade-up/upgrade of our existing Chromium Controller to a CytAssist needed for single-cell and spatial transcriptomics projects. Together, these items will allow high-resolution mapping of cellular states and spatial gene expression across multiple NIDDK projects.
4.0 REQUIREMENTS
We require the following 10x Genomics brand-name items:
Part No. Manufacturer Description UOM Qty
Xenium Prime and GEM-X Flex
1000672 10X Genomics Xenium Prime 5K Mouse Pan Tissue and Pathways Assa Each 2
1000766 10X Genomics Xenium Prime 5K Add on Each 1
1000781 10X Genomics GEM-X Flex Sample Preparation v2 Kit, 48 rxns Each 1
1000797 10X Genomics GEM-X Flex Gene Expression Mouse 4-plex, 16 sample Each 2
1000791 10X Genomics GEM-X Flex Gene Expression Chip Kit, 4 chips Each 1
Controller trade-up of Chromium Controller instrument serial # 30593
1000441 10X Genomics Visium CytAssist Each 1
1000499 10X Genomics Visium CytAssist Reagent Each 1
1000886 10X Genomics Visium CytAssist Alignment Aid Each 1
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