Appendix D.docx

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Biosequence Search
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ACQ-27-0065
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Appendix A.docx DOCX document
Appendix C.docx DOCX document
RFI Attachment 3 - Question and Answer Sheet.xlsx XLSX spreadsheet
RFI Attachment 1 - RFI Response Template_v0.1.xlsx XLSX spreadsheet
ACQ-27-0065 - RFI Biosequence Tool.pdf PDF
Appendix B.docx DOCX document
RFI Attachment 2 - Biosequence Search SOO.pdf PDF

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Date: May 1, 2026 Appendix D. Pain Points and Capability Gaps Table D-1. Pain points and capability gaps

Workflow
Pain Point ID
Workflow Stage
Current-State Problem
Why It Takes Time
Capability Examiners Do Not Currently Have
Potential SI Support
Pain Points and Gaps
P-01
Case review
Examiners must manually read the specification, claims, and sequence listing
Files can be long, technical, and sequence-heavy
Automated case-file synthesis into a search-ready summary
SI-assisted case summarization
Pain Points and Gaps
P-02
Search-target identification
Examiners must manually identify all relevant SEQ ID NOs, fragments, variants, and claim qualifiers
Claims may contain many sequence embodiments and structural limitations
Automated extraction of search-relevant sequence features
SI feature extraction
Pain Points and Gaps
P-03
Search-strategy development
Examiners must manually determine search type, parameters, and database selection
Search logic depends on detailed technical judgment
Automated recommendation of focused sequence-search strategies
SI strategy generation
Pain Points and Gaps
P-04
Broad claims
Large numbers of claimed sequences create grouping and scope problems
Queries must be organized carefully to reflect claim breadth
Automated query grouping and over-limit planning support
SI query grouping and request drafting
Pain Points and Gaps
P-05
Result review
ABSS can generate large, multi-file outputs across multiple databases
Examiner must manually inspect many hits, alignments, and duplicate records
Automated triage, ranking, and clustering of result files
SI result prioritization
Pain Points and Gaps
P-06
Reference identification
Examiners must manually connect sequence hits to underlying references
Identifier-to-reference mapping is repetitive and slow
Automated linking and prioritization of source references
SI reference mapping
Pain Points and Gaps
P-07
Cross-file synthesis
Relevant hits may be distributed across many files and databases
Examiner must reconcile overlapping records manually
Automated cross-file consolidation and summary
SI cross-result synthesis
Pain Points and Gaps
P-08
Documentation
Examiners must summarize search work and rationale manually
Requires reconstructing and condensing a complex workflow
Automated drafting of examiner-editable search summaries
SI documentation support

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