Amendment 4 CC4CARB.pdf

This amendment modifies a request for proposals issued by the National Institute of Allergy and Infectious Diseases seeking to establish a Chemistry Center for Combating Antibiotic-Resistant Bacteria. Amendment 4 extends the proposal due date from March 16, 2020 to March 23, 2020 at 3:00PM EST in response to the COVID-19 pandemic. The aim of the solicitation is to create an innovative chemistry center focused on synthesizing and delivering rationally designed compound libraries to support antibacterial drug discovery programs targeting Gram-negative bacteria, in alignment with objectives outlined in the National Action Plan for Combating Antibiotic-Resistant Bacteria. The center is expected to implement a transparent process for external design proposals, demonstrate robust synthetic capabilities for diverse chemotypes, and seamlessly manage the storage and distribution of resulting compound libraries to researchers. A single principal investigator accountable for coordination and project management is required.