RFTP 002 HPV.pdf

Department of Health and Human Services Public Health Service Centers for Disease Control and Prevention National Center for Chronic Disease Prevention and Health Promotion (NCCD) Division of Cancer Prevention and Control (DCPC) Atlanta, GA 30333

DATE ISSUED: April 14, 2008 DATE RESPONSE DUE: May 15, 2008

REQUEST FOR TASK ORDER PROPOSAL (RFTP) NO: 002

TITLE: Human Papilloma Virus (HPV) Long-Term Impact Study in Medically Underserved, Low-income Populations in the United States

Contract Reference: This RFTP is consistent with the tasks in section C.4(1)(B) – Research Support contained in RFP 2008-N-10240.

Funding Range:

Phase I Less than $100,000 X More than $100,000 but less than $300,000 More than $300,000 but less than $500,000 More than $500,000 but less than $750,000 More than $750,000 but less than $1,000,000 More than $1,000,000

Phase 2 Less than $100,000 X More than $100,000 but less than $300,000 More than $300,000 but less than $500,000 More than $500,000 but less than $750,000 More than $750,000 but less than $1,000,000 More than $1,000,000

Technical Proposal Preparation:

The contractor shall submit a technical proposal addressing understanding the project, the tasks required an each of the evaluation criteria. The proposal shall not exceed 15 single-spaced typewritten pages excluding resumes and charts which are contained in appendices. Resumes shall be not more than 3 pages in length and should contain the proposed staff education and experience relevant to this task order. Technical proposals which merely restate the RFTP requirements may not receive favorable consideration.

Budget Format Suggestion:

Contractors should provide an itemized budget breakdown for each task set forth below, including all estimated direct and indirect costs as well as the fee allocable to each task. The budget should contain a summary of all tasks as well. A budget narrative should be included if necessary to explain entries.

A. BACKGROUND AND NEED

Cancer adversely affects the nation’s health and welfare through premature death, disability, medical costs, and lost productivity. Studies have reported that cancer is associated with the highest prevalence of impairment and amount of work loss of any chronic disease. Reducing the health and economic burden of human papillomavirus (HPV)-associated cancers is an important potential benefit of public health interventions such as cervical cancer screening and HPV vaccination. HPV, a sexually transmitted infection, is considered to be the most important risk factor for cervical cancer. It is also believed to be causally associated with approximately 90% of anal; 40% of vaginal, vulvar, and penile; 25% of oral cavity and 35% of oropharyngeal cancers.

In 2006, US health authorities took a significant step towards reducing the burden of cervical cancer and other anogenital cancers associated with HPV by approving and recommending the first HPV (a quadrivalent) vaccine (Gardasil®, manufactured by Merck) for girls and young women age 9 to 26 years. The vaccine protects against HPV types 6/11 and 16/18. In addition to the quadrivalent vaccine, a bivalent HPV vaccine (Cervarix™) for HPV types 16/18 is being developed by GlaxoSmithKline (GSK) and is expected to be licensed in the near future. The efficacy of the quadrivalent vaccine in preventing cervical intraepithelial neoplasian (CIN)2/3 among those that are naïve for HPV 16/18 is reported to be almost 100%. Its impact on the general population (one that is already exposed to HPV 16/18 types) or even in specific populations may differ due to incomplete coverage, incomplete dosage, and effectiveness of the vaccine.

In anticipation of the approval of the first HPV vaccine to prevent cervical cancer and other anogenital cancers, several researchers developed mathematical models to project both the short-and-long-term epidemiologic and economic impact of vaccination on the general population. The overarching aim of these modeling studies was to provide structured evidence on clinical and economic outcomes in a form that can help to inform decisions about various alternative vaccination and screening strategies to maximize health care resource allocation. All models demonstrated that vaccination can significantly reduce the incidence of cervical cancer in the long-term and that it can be cost-effective at various screening strategies.

Prior studies have not modeled the long-term impact of HPV vaccination on the burden of cervical cancer or other HPV-associated cancers (e.g., vaginal, vulvar, anal, oral cavity/oropharyngeal) among medically underserved, low-income women receiving federally-funded cervical cancer screening. While modeling results from the general population may be necessary to provide insight to policy makers on the projected long-term benefits and costs of various alternative vaccination and screening strategies, those results may not adequately provide such information for medically underserved, low-income women receiving federally-funded cancer screening. Historically, these women may rarely or never receive screening and may be most likely to develop cervical cancer.

Depending on their economic status, the type of vaccine to be used, and implementation issues, the age-cohort currently receiving the HPV vaccine may qualify for enrollment in CDC’s National Breast and Cervical Cancer Early Detection Program (NBCCEDP) in the very near future. Estimating the impact of HPV vaccination on cervical cancer screening to this population would provide critical information to better understand choices, increase effectiveness of health services delivered, and develop various scenarios to plan for future directions of NBCCEDP.

To assist NBCCEDP decision makers in preparing for future potential changes in cervical cancer screening policies, we propose to use the HPV cohort model to estimate the long-term impact of HPV vaccination on the burden of cervical and other HPV-associated cancers in the NBCCEDP-eligible population. We propose to adopt a model developed by Kohli et al (2007). The model will be calibrated to the NBCCEDP population. The results from this study may provide useful information to public health policy makers to inform decisions on developing and planning future cervical cancer control policies in medically underserved and uninsured populations.

B. OBJECTIVE

The purpose of this project is threefold: (1) to estimate the long-term public health benefits and costs associated with HPV 16/18 vaccination on the existing national cervical cancer screening program designed for medically underserved, low-income populations; (2) to estimate how an HPV vaccination program may impact the disease burden of other HPV-associated cancers on medically underserved, low-income populations; and (3) to estimate how an HPV vaccination program might change screening behavior based on current disease burden in this population. This project is divided into two phases. Phase I will examine objective #1 and phase II will examine objectives #2 and #3.

Specific Objectives to Be Accomplished

The specific objectives of this project are to:

(1) Estimate the long-term public health impact on cervical cancer screening to medically underserved, low-income age-eligible women in the NBCCEDP by the introduction of HPV vaccination;

(2) Estimate the cost-effectiveness of the long-term impact on cervical cancer screening to eligible women using various screening strategies by the introduction of HPV vaccination program;

(3) Estimate the long-term public health impact and cost-effectiveness by race/ethnicity stratified by mutually executive categories (i.e., non-Hispanic white, non-Hispanic black, Hispanic, and non- Hispanic other).

Other objectives to be addressed in this project include:

(a) Estimating the incremental benefits and costs of vaccinating males and to examine how vaccinating this population will impact the burden of cervical and other HPV-associated cancers in the NBCCEDP population;

(b) Estimating the impact and cost-effectiveness on the burden of cervical and other HPV-associated cancers to eligible women if the duration of vaccine protection is 10 years or less;

(c) Estimating the impact on the incidence of cervical cancer in the NBCCEDP population if a large number of the age-cohort currently recommended for the vaccine did not complete the 3-dose series;

(d) Estimating the time in which the full or partial impact of vaccination will be realized in the NBCCEDP population.

C. SCOPE OF WORK

Independently, and not as an agent of the Government, the Contractor shall furnish to CDC, all necessary personnel, facilities, supplies, and equipment to estimate the long-term HPV vaccination impact in medically underserved, low-income populations as described above.

D. DESCRIPTION OF WORK

This project will be divided into two phases. Phase I will address objective #1 and phase II will address objectives #2 and #3. In each of these phases, the main goal is to predict the long-term public health and economic impact of a vaccine that protects against HPV infection and the potential reduction in the incidence and mortality of cervical cancer disease in medically underserved, low-income women who may be eligible for the NBCCEDP. It is expected that data generated from this project will be used for decision making about program policy and will help planners determine the portion of the eligible population that the program cannot serve, given available resources and the HPV vaccination effect.

In addition to these outcomes, we anticipate at least three manuscripts from this project to be submitted to a peer-reviewed journal. The CDC technical monitor will take the lead in drafting these manuscripts and the remaining CDC project team will be co-author. The Contractor shall be invited to be co-author.

Tasks. Specifically, the Contractor will be required to perform the following activities and develop the following tasks within the time frames specified:

Task 1. Initial meeting with the CDC technical monitor

Within one week after the award of the task order, the contractor shall, in person or by teleconference conduct an initial meeting with the CDC technical monitor. At this meeting, the contractor and CDC technical monitor shall schedule the project kickoff meeting.

Task 2. Kickoff meeting, study design, and development

Within three weeks after the award of the task order, the contractor and CDC project team shall have a face-to-face kickoff meeting. Items to be discussed during this kickoff meeting shall include, but are not limited to, schedule of monthly conference calls, summary notes of all monthly conference call, monthly progress report, and description of study design, methods for data collection, data sources, model development, potential estimation techniques, and specific outcomes. After this meeting the contractor shall incorporate the agreed upon project process into the final study work plan. Both phase I and II project work plans shall be discussed at this meeting.

Task 3. Submission of the final work plan

Within six weeks after the award of the task order, the contractor shall forward to the CDC technical monitor the final project work plans for phases I and II. Work plans shall include the contractor’s proposed methods to perform task order requirements within the stated time frames, and budget.

Task 4. Review current available HPV cohort models

Within five months after the award of the task order, the contractor shall conduct a detailed literature review on currently available HPV cohort models and assess their applicability to the NBCCEDP population. The draft of this review shall be submitted to CDC for review and comment.

Task 5. Submit report of the draft model structure and design, list of variables, and identify sources of data for the study

Within eight months after the award of the task order, based on the results of the literature review, the contractor shall draft a model structure and design, and develop a list of variables, and sources of data for the study. Included in the model structure and design will be a report outlining the methods, assumptions, and preliminary results from phase I of the project. The contractor shall submit the outcome of these activities to CDC for review and comment and discuss the preliminary intermediate results with CDC at one of the monthly conference calls. The contractor shall incorporate CDC suggestions agreed upon on this conference call.

Task 6. Submission of preliminary results of phase I of the project

Within 12 months after the award of the task order, the contractor shall conduct analyses to estimate the long-term HPV vaccination impact in medically underserved, low-income populations. The preliminary results shall be submitted to the CDC project team. The contractor shall arrange for a teleconference with the CDC project team to discuss the preliminary results and solicit comments and suggestions. The contractor shall incorporate the suggestions agreed upon at this teleconference meeting.

Task 7. Submission of project’s phase I final report and presentation to CDC in Atlanta

Within 15 months after the award of the task order, the contractor shall conduct the final analyses including all other adjustments found to be necessary in accordance with the modifications made in Task #6. Perform model validation by using independent verification and validation methods or other methods of model validation that is agreed upon by the contractor and CDC project team. The contractor shall submit the final report to the technical monitor who will distribute the report to CDC project team and Division management officials for review, comments, and suggestions. The contractor shall schedule a formal presentation in Atlanta to present the project’s phase I findings to DCPC management and other staff. At this presentation, the views of DCPC management, project team, and others will be solicited. Suggestions for possible methods of disseminating the project’s results including journals for publication will be discussed.

Task 8. Beginning of phase II: Revised work plan and models developed in phase I for phase II

Within 18 months after the award of the task order, the contractor shall revise the work plan and the model developed in phase I to fit other HPV-associated cancers. CDC and the contractor shall agree on at least two other HPV-associated cancers that shall be modeled in this project. The contractor shall collect additional data as needed to populate the model. Conduct preliminary analyses on these cancers and submit to the CDC project team for review and comments.

Task 9. Submission of preliminary results of phase II of the project

Within 24 months after the award of the task order, the contractor shall conduct analyses to estimate the long-term impact of HPV-vaccination to prevent other HPV-associated cancers in medically underserved, low-income populations. The preliminary results shall be submitted to the CDC project team. The contractor shall arrange for a teleconference with the CDC project team to discuss the preliminary results and solicit comments and suggestions. The contractor shall incorporate the suggestions agreed upon at this teleconference meeting.

Task 10. Submission of project’s phase II final report and presentation at CDC in Atlanta

Within 30 months after the award of the task order, the contractor shall conduct the final analyses including all other adjustments found to be necessary in accordance with the modifications made in Task #9. Perform model validation by using independent verification and validation methods or other methods of model validation that is agreed upon by the contractor and the CDC project team. The contractor shall submit the final report to the technical monitor who will distribute the report to the CDC project team and Division management officials for their review, comments, and suggestions.

The contractor shall DCPC management and other staff. At this presentation, the views of DCPC management, the project team, and others will be solicited. Suggestions for possible methods of disseminating the project’s results including journals for publication will be discussed.

E. DELIVERABLES:

Tasks DESCRIPTION NUMBER OF

COPIES

DUE DATE

1 Initial meeting with the CDC technical monitor

Within a week after the award of the task order.

2 Kickoff meeting, study design, and development:

Summary notes of all monthly conference calls, monthly progress report, and description of study design, methods for data collection, data sources, model development, potential estimation techniques, and specific outcome

Electronic

Within 3 weeks after the award of the task order.

3 Final work plan Electronic

Within 6 weeks after the award of the task order

4 Draft review of current available HPV cohort models

Within 5 months after the award of the task order

5 Report of the draft model structure and design, list of variables, and sources of data for the study

Within 8 months after the award of the task order

6 Preliminary results of phase I of the project Electronic Within 12 months after the award of the task order

7 Phase I final report and presentation to CDC in Atlanta

Within 15 months after the award of the task order

8 Revised work plan and models developed in phase I for use in phase II

Within 18 months after the award of the task

9 Preliminary results of phase II of the project

Within 24 months of after the award of the task.

10 Phase II final report and presentation at CDC in Atlanta

Within 30 months of after the award of the task.

Note: The contractor shall submit 10 hard copies of all final reports as well as an electronic copy of the final reports.

Ten (10) hard copies for both phase I and II

All documents listed as deliverables shall be submitted to the Technical Monitor and the Project Officer in paper (1 hard copy to each) as well as electronic format (e.g., MS Word, Access, or Excel in a PC compatible format). All other deliverables shall be submitted in the format specified by the Project Officer or Technical Monitor.

F. PERIOD OF PERFORMANCE

Phases shall be completed as follows:

Phase I: Within 15 months following the date of award of the task order.

Phase II: Within 30 months following the date of award of the task order.

All work shall be completed within 30 months following the date of award of the task order.

G. RIGHTS IN DATA

The following pre-award Federal Acquisition Regulation (FAR) provisions apply to this request for task order proposal, and are hereby incorporated by reference:

Number Title Date

FAR 52.227-17 Rights in Data—Special Works Dec 2007

CDC will assume principal scientific leadership for the project. It is expected that at the completion of the project, data will remain within DCPC and will be available to CDC staff for data analyses and publications. All data generated under this task order shall become and remain the property of CDC.

The contractor may not use or publish from this data without prior written consent of the contracting officer.

H. PERFORMANCE

Performance Based Matrix

Deliverable or

Service Required Measure of

Success Standards – Criteria for Acceptance

Method of Surveillance

Incentive1

Task C.4 (1)

(A)(1) Planning and Coordinating External Peer Review activities

1. Work Quality

2. Compliance

3. Accuracy

4. Timeliness

5. Business Relations

1. 100% of work products are technically correct with no correction required by the government.

2. 100% of all work products adhere to respective CDC and Federal government regulatory and statutory guidelines

3. 100% of all work products are accurate in presentation and adherence to accepted elements of style with no errors.

4. 100% of work products are completed, in ready state, on time as specified by CDC customer.

5. 100% of the time the contractor staffing

Surveillance system will be primarily customer observations.

See QASP for details.

Payment of contract labor rate for satisfactory service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using annual Contractor Performance Report. The evaluation will be considered when future contract selections are made.

demonstrates reasonable and cooperative behavior, a commitment to customer satisfaction, and a concern for the interest of the customer

Task C.4 (1)

(A)(2) Support Health Education Activities

1. 100% of work products are technically correct with no correction respective CDC and Federal government regulatory and statutory guidelines

3. 100% of all work products are accurate in presentation and adherence to accepted elements of style with no errors.

4. 100% of work products are completed, in ready state, on time as specified by CDC customer.

5. 100% of the time the contractor staffing demonstrates reasonable and cooperative behavior, a commitment to customer satisfaction, and a concern for the

Surveillance system will be primarily customer observations.

See QASP for details.

Payment of contract labor rate for satisfactory service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using annual Contractor Performance Report. The evaluation will be considered when future

(B)(1) Conduct Statistical Programming and Analysis

1. 100% of work products are technically correct with no correction respective CDC and Federal government regulatory and statutory guidelines

3. 100% of all work products are accurate in presentation and adherence to accepted elements of style with no errors.

4. 100% of work products are completed, in ready state, on time as specified by CDC customer.

5. 100% of the time the contractor staffing demonstrates reasonable and cooperative behavior, a commitment to customer satisfaction, and a concern for the interest of the customer

Surveillance system will be primarily customer observations.

See QASP for details.

Payment of contract labor rate for satisfactory service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using annual Contractor Performance Report. The evaluation will be considered when future

(B)(2) Scientific Publication Support

1. 100% of work products are technically correct with no correction respective CDC and Federal government accurate in presentation and adherence to accepted elements of style with no errors.

4. 100% of work completed, in ready state, on time as specified by CDC customer.

5. 100% of the time the contractor staffing demonstrates reasonable and cooperative behavior, a commitment to customer satisfaction, and a concern for the interest of the customer

Surveillance system will be primarily customer observations.

See QASP for details.

Payment of contract labor rate for satisfactory service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using annual Contractor Performance Report. The evaluation will be considered when future

(B)(3) Conduct Literature Reviews

1. 100% of work products are technically correct with no correction respective CDC and Federal government accurate in presentation and adherence to accepted elements of style with no errors.

4. 100% of work products are completed, in ready state, on time as specified by CDC customer.

5. 100% of the time the contractor staffing demonstrates reasonable and cooperative behavior, a commitment to customer satisfaction, and a concern for the interest of the customer

Surveillance system will be primarily customer observations.

See QASP for details.

Payment of contract labor rate for satisfactory service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using annual Contractor Performance Report. The evaluation will be considered when future

(C) Strategic Planning Services

1. 100% of work technically correct with no correction

Surveillance system will be primarily customer observations.

See QASP for details.

Payment of contract labor rate for satisfactory service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using respective CDC and Federal government accurate in presentation and adherence to accepted elements of style with no errors.

4. 100% of work products are completed, in ready state, on time as specified by CDC customer.

5. 100% of the time staffing demonstrates reasonable and cooperative behavior, a commitment to customer satisfaction, and a concern for the interest of the customer annual Contractor Performance Report. The evaluation will be considered when future

Task C.4 (2)

The Contractor shall Follow the Task Order Award Process

1. Timeliness

1. 100% of Task Order proposals are submitted on time

Surveillance system will be primarily customer observations.

See QASP for details

Failure to follow the Task Order Award Process may result in loss of winning Task Order

2. Work Quality

2. 100% of Task Order proposals are technically compete as government

Task C.4 (3)

The Contractor shall provide a knowledgeable Project Director

1. Cost Control

2. Business

3. Management of Key Personnel

1. 100% of the time the contractor demonstrates attention to cost control, without sacrificing work quality

2. 100% of the time staffing demonstrates reasonable and cooperative behavior, a commitment to customer satisfaction, and a concern for the

3. 100% of the time, the contractor provided technical experts that were highly qualified and effective in performing the required services;

the appropriate number of personnel were assigned to the project; and the delivered products reflected the skill and standardization required by the

Surveillance system will be primarily customer observations.

Payment of contract labor rate for satisfactory service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using annual Contractor Performance Report. The evaluation will be considered when future

Task C.4 (4)

The contractor shall meet with the Government at start of each task order

2. Business

1. 100% of Task Order Award meetings are conducted within the specified time

2. 100% of the time staffing demonstrates reasonable and cooperative behavior, a commitment to customer satisfaction, and a concern for the interest of the customer

Surveillance system will be primarily customer observations.

service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using annual Contractor Performance Report. The evaluation will be considered when future

Task C.4 (5)

The contractor shall provide monthly status report

2. Work Quality

1. 100% of Monthly Status reports are submitted on time

2. 100% of Monthly Status reports are submitted on time

Surveillance system will be primarily customer observations.

service.

Rating of “5” Outstanding, in the NIH Contractor Performance System (CPS) evaluation using annual Contractor Performance Report. The evaluation will be considered when future

I. EVALUATION CRITERIA

This task order shall be awarded to the offeror whose proposal is considered to be the most advantageous to the Government, price and other factors (identified below) considered. Technical Factors will be more important than price in this evaluation. The Government will not make an award at a significantly higher overall price to the Government to achieve only slightly technical superiority.

Technical Evaluation

Technical evaluations for this RFTP are as follows

Criteria Value of Criteria

A. Staffing and Management 25 B. Technical Approach 40 C. Similar or previous experience 35

A. Staffing and Management

Contractors are to provide (1) a staffing plan that demonstrates an understanding of the labor requirements for this task order; and (2) a management plan that describes the approach for managing the work, to include subcontract management if applicable. Contractors should specify the Project Leader and Task Manager by name and indicate their degrees, areas of expertise and relevant experience. Contractors are to provide information reflecting experience of assigned staff that is appropriate to the complexity, size and subject matter of the proposed work and should include expertise in state transition cohort Markov modeling in HPV and cervical cancer.

If the contractor plans to staff the Project Leader or Task Manager positions with new hires, letters of intent from new employees should be included. In addition, contractors are encouraged to retain outside consultants with special expertise relevant to this task order. If the contractor plans to exercise this option, letters of intent from outside investigators should also be included. The CVs of all key personnel who will be affiliated with this task order should be provided in the appendices. The proposal should also describe the project’s organization including an organizational chart of staff assigned to the project. In addition, the proposal should also describe relationships and partnerships with other organizations which are relevant to this task.

This criterion will be evaluated according to the soundness, practicality, and feasibility of the offeror’s staffing and management plans for this task order.

B. Technical Approach

Contractors are expected to demonstrate in detail an understanding of the study goals and steps necessary to carry out the study. The contractors are to provide a discussion of their technical approach for providing the services required for this task order including, but not limited to the development of the study design and methods of estimating the long-term impact of HPV 16/18 vaccination on the existing national cervical cancer screening program designed for medically underserved, low-income populations. In addition, the contractor should also provide a detailed modeling approach for phase I and II of this project and address each of the objectives articulated in this project. The contractor’s proposal should specify how all tasks in the Description of Work will be accomplished. The contractor is to provide a detailed time line for the accomplishment of tasks.

This criterion will be evaluated according to the soundness, practicality, and feasibility of the contractor’s technical approach for providing the services required for this task order.

C. Similar or Previous Experience

• The contractor should provide information reflecting experience that is similar in complexity and size to the proposed project. The contractor must provide evidence of experience in modeling diseases for medically underserved, low-income populations. The contractor must demonstrate experience in the following:

• Use of cohort Markov simulation models in estimating long-term impact of HPV vaccination or other preventive health services for a national screening program designed for medically underserved, low-income populations.

• Use of simulation models to estimate net benefits of a national cancer program for underserved populations by race/ethnicity.

• Use of economic analyses and evaluation techniques in modeling chronic disease prevention programs.

COST EVALUATION

A cost analysis of the business cost proposal shall be conducted to determine the reasonableness of the proposal.

TECHNICAL MONITOR: To be Determined

PROJECT OFFICER Christine Dauer

Public Health Advisor Division of Cancer Prevention and Control (DCPC)

National Center for Chronic Disease Prevention and Health Promotion 4770 Buford Highway NE, MS K-55 Atlanta, Georgia 30341-3724

Telephone: 770 488-3056

J. INSTRUCTIONS TO CONTRACTORS

As a contract holder of CDC/NCCD/DCPC Multiple Award Contracts, this is considered your fair opportunity for consideration of the RFTP in accordance with FAR 16.505(b)(1) and Section H of the basic contract.

The following pre-award Federal Acquisition Regulation (FAR) provisions apply to this request for task order proposal, and are hereby incorporated by reference:

Number Revision Title 52.215-1 JAN 2004 Instructions to Offerors—Competitive Acquisition

Your response must be submitted in two parts: a Technical, and a Business proposal. Each part shall be separate and complete in itself so evaluation of one may be accomplished independently of the other.

Required Statements: Your proposal should indicate that the proposal is predicated on the terms and conditions of the NCCD Contract No.______________; is valid for a period of 60 days; and a brief statement indicating current or future commitments during the proposed performance period and what impact the commitments might have on performance if awarded. Proposals are not to include any additional information regarding past performance, letters of reference, or corporate capability. This information was submitted previously when the contracts were awarded. The proposal is to reference only the proposed work and budget for the referenced RFTP. Proposals containing information that is not specific to the proposed task will not be evaluated.

Awardees are not required to submit a proposal in response to this request for task proposal.

The Government shall not pay any cost for the preparation and submission of proposals submitted in response to this RFTP. All communications concerning this project prior to the award of a task order under this RFTP shall be with the Contracting Officer or the Project Officer. Communications with unauthorized individuals concerning a specific RFTP prior to award may jeopardize your eligibility for award.

ATTACHMENT

Form 684 Research Determination

Form 684--Research Determination for this project has been submitted through the DCPC electronic system. The form 684 for this project was approved by the Division of Cancer Prevention on August 30, 2007.

Department of Health and Human Services