Stimulant and polysubstance use, inflammation and SEX effects on myocardial disease in HIV (SPISE)

Active Project Grant Awarded Last action

Award ID
RM1DA063351
Recipient
Awarding agency
Obligated
$8,187,703

Award facts

Assistance listing
93.279 Drug Use and Addiction Research Programs
Completion date 28% complete
Place of performance
San Francisco, CA 94121, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Heart failure (HF) and other cardiovascular diseases (CVDS) constitute a leading cause of death in people with HIV (PWH). Compared to people without HIV, PWH have greater HF risk and we have shown that the difference in risk may be greater in women than men. However, traditional HIV and CVD risk factors do not fully explain the higher HF risk. Notably, symptomatic HF is often preceded by subclinical changes in left ventricular structure and function detectable by echocardiography (ECHO), and even sooner by cardiac magnetic resonance imaging (CMR). Recognizing myocardial disease determinants and the mechanistic contributors early in the disease process is imperative to identify targets for HF prevention and treatment in PWH. Controlled stimulants like cocaine and methamphetamine are known cardiotoxins, but their role in myocardial remodeling among PWH is unclear. Stimulant use is higher among PWH than the general population, yet stimulant use is poorly assessed in large HIV and CVD studies. IT is either pooled with other substances or lacks details about patterns of use, level of exposure, and synergistic influences with other substances - hampering our ability to understand the potentially outsized role of stimulant use in the pathogenesis of HIV and myocardial disease in PWH. We propose "stimulant and polysubstance use, inflammation, and SEX effects on myocardial disease in HIV (SPISE)" a research program within the multicenter aids cohort study (MACS)/women's interagency HIV study (WIHS) combined cohort study. Our findings from WIHS suggest that sustained (and not any) self-reported substance use is associated with cardiac dysfunction, and sustained cannabis may have a protective effect, emphasizing a need to assess substance use patterns and different influences of multiple substances. Furthermore, women with HIV who reported prior cocaine use may have a larger HIV-1 reservoir than never users, even after adjusting for art adherence, which could explain persistent viremia in some women with implications to inflammation and epigenetic maladaptation. SPISE's overarching research goal is to rigorously characterize substance use patterns (using serial urine drug toxicology measures and self-report) and determine its effect on structural heart disease and myocardial disease through the longitudinal spice-ECHO and prospective spice-CMR studies, respectively; whether DNA methylation and the inflammatory proteome mediates these effects; and how HIV and SEX influence the pathways. SPISE will establish a transdisciplinary infrastructure to comprehensively investigate the biological basis of substance-associated myocardial disease at multiple points of the mechanistic pathway. Our findings will be shared with the scientific community to stimulate and sustain research in substance use and HIV. SPISE has the potential to transform current research paradigms that do not consider independent stimulant use effects, promote new approaches for implementation research that acknowledge the importance of substance use patterns, inform biomedical and behavioral interventions that are SEX-specific, and direct resource-intensive risk reduction strategies to those PWH who use substances and are at highest CVD risk.

Transactions

Action Obligated Date
Amendment $2,278,072
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $1,969,877
Amendment $1,969,877
Original award $1,969,877

Subawards

Subrecipient Amount Awarded
University Of California, San Francisco Dr. Abelman will provide expertise in sex differences and menopausal effects on cardiometabolic outcomes and attend the annual SPISE leadership and investigator… $46,802
The Regents Of The University Of California. San Francisco UCSF will perform comprehensive drug testing by mass spectrometry to test for all drugs of interest. For SPISE-Echo, we will test participants samples at 2… $475,804
Emory University Emory University will: - recruit and enroll participants from the MWCCS Atlanta site, perform MRI scanning per protocol, and participate in data review and… $171,172
Albert Einstein College Of Medicine The Albert Einstein College of Medicine will recruit and enroll participants from the MWCCS Bronx site, perform MRI scanning per protocol, and participate in… $269,789
The Johns Hopkins University This is the scope of work (SOW) for the Johns Hopkins investigators and research team (MPI, Katherine C. Wu), for the research project sponsored by NIDA.… $350,515
The Johns Hopkins University $799,980
New York University The goal of this project is to lead the measurement of the HIV reservoir in CD4+ T-cells and to perform epigenomic analysis of PBMC in order to conduct EWAS… $632,619

Quick answers

Who received award RM1DA063351?

RM1DA063351 was awarded to Northern California Institute For Research And Education, Inc. by National Institute on Drug Abuse (National Institutes of Health) on July 15, 2025.

How much is award RM1DA063351 worth?

$8,187,703 has been obligated on RM1DA063351.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login