Collaborative pediatric critical care research network

Active Project Grant Awarded Last action

Award ID
PL1HD105462
Recipient
Awarding agency
Obligated
$27,477,514

Award facts

Completion date 87% complete
Originally
Funding
  • $25,064,340.00 Federal
  • $2,413,174.00 Non-federal
Place of performance
Emigration Canyon, UT 84108, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
In 2005, the eunice kennedy shriver national institute of child health and human development (NICHD) established the collaborative pediatric critical care research network (CPCCRN) to support multi-institutional randomized controlled trials (RCTS) and observational studies in critically ILL children. This PL1 proposal from the university of utah is submitted on behalf of a newly congured CPCCRN network increased to 12 clinical sites and 12 ancillary sites with > 61,000 annual ICU admissions. The expanded network has geographic, racial/ethnic and socioeconomic diversity, and will be a platform to develop additional investigators, especially young clinician scientists. The network will conduct a highly innovative large-scale multi-center study of personalized, targeted immune modulation in children with sepsis-induced multiple organ dysfunction syndrome (MODS). The study includes two concurrent, immunophenotype-driven placebo controlled RCTS that will address the central hypoth- esis that individualized, pathophysiology-specic immunomodulation will improve outcomes from sepsis-induced MODS in children. This study builds on R01-funded CPCCRN studies that have demonstrated the existence of specic immune phenotypes among children with sepsis-induced MODS (R01GM108618 PI: carcillo) and SUC- cessful reversal of immunosuppression by administration of the immunostimulant granulocyte macrophage-colony stimulating factor (GM-CSF) (R01GM094203 PI: hall). IT also complements the ongoing NICHD R01-funded study investigating the risk factors for immunoparalysis in pediatric MODS (R01HD095976 MPI: hall, zuppa). This application has three specic aims: (1) implement the CPCCRN organization; (2) mount a comprehen- sive strategy for development of young clinician scientists and submission of rigorous proposals to fund additional research in critical care; (3) conduct the personalized immunomodulation in sepsis-induced MODS study. The RST trial focuses on the use of the drug GM-CSF for the reversal of immunoparalysis. The second trial uses adaptive randomization and focuses on the drugs anakinra and tocilizumab for the targeted treatment of hyper- inammation. The primary outcome of both trials will be duration and severity of organ dysfunction using the cumulative pelod-2 score, and secondary outcomes will assess health related quality of life and family function- ING at 3 and 12 months. The personalized immunomodulation in sepsis-induced MODS study represents a paradigm shift in the man- agement of pediatric sepsis, nally moving beyond simple supportive care. We are uniquely positioned to SUC- cessfully execute this approach to personalized, real-time, pathophysiology-directed sepsis treatment, leveraging the strengths of a diverse and highly accomplished group of investigators to deliver high-impact science to the benet of our patients and our ELD.

Transactions

Action Federal Non-federal Date
Amendment $2,386,195 $0
Amendment $0 $0
Amendment $2,582,551 $0
Amendment $0 $0
Amendment $0 $0
Amendment $0 $0
Amendment $150,000 $0
Amendment $150,000 $0
Amendment $2,572,115 $0
Amendment $2,572,115 $0
Amendment Cpccrn precise supplement $173,992 $0
Amendment $2,412,756 $0
Amendment Cpccrn precise supplement $2,412,756 $0
Amendment $2,412,756 $0
Amendment $2,412,756 $0
Amendment $0 $0
Amendment $0 $0
Amendment $0 $0
Amendment $0 $0
Amendment $0 $0
Amendment $2,413,174 $0
Original award $2,413,174 $2,413,174
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Subawards

Subrecipient Amount Awarded
University Of California, Davis Collaborative Pediatric Critical Care Network $50,000
Variety Childrens Hospital $50,000
Regents Of The University Of Michigan $35,000
University Of California, San Diego $50,000
The University Of Texas Southwestern Medical Center $50,000
The Medical University Of South Carolina $50,000
University Of Pittsburgh - Of The Commonwealth System Of Higher Education $35,000
Childrens Healthcare Of Atlanta, Inc. $50,000
Case Western Reserve University $50,000
Children's Hospital Medical Center Of Akron $50,000
Regents Of The University Of Minnesota $35,000
Research Institute At Nationwide Children's Hospital $275,000
Children's Research Institute $35,000
Central Michigan University $35,000
Baylor College Of Medicine $35,000
The Children's Hospital Of Philadelphia $35,000
Children's Hospital Of Orange County $50,000
The Medical College Of Wisconsin, Inc. $50,000
The Pennsylvania State University $50,000
Arkansas Children's Research Institute $50,000
The Regents Of The University Of California. San Francisco $35,000
The Regents Of The University Of Colorado $35,000
Childrens Mercy Hospital $50,000
Children's Health Care $50,000
Childrens Hospital Medical Center $50,000
Baylor College Of Medicine $50,000
Children's Hospital LOS Angeles $35,000
Childrens Hospital Medical Center Collaborative Pediatric Critical Care Research Network $50,000
Trustees Of Indiana University $50,000
Show all 29

Quick answers

Who received award PL1HD105462?

PL1HD105462 was awarded to University Of Utah by National Institute of Child Health and Human Development (National Institutes of Health) on August 13, 2021.

How much is award PL1HD105462 worth?

$27,477,514 has been obligated on PL1HD105462: $25,064,340 in federal funding and $2,413,174 in non-federal funding.

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