The New York Structural Biology Center, Inc.

The New York Structural Biology Center, Inc., a tax-exempt nonprofit consortium headquartered in New York, New York, operates as a federal grant recipient delivering structural biology research infrastructure, training, and access to cryo-electron microscopy (cryo-EM) and nuclear magnetic resonance (NMR) instrumentation to NIH-funded researchers nationwide. NYSBC is a member-serving organization comprising nine research institutions across New York State and holds no federal contracts; it operates exclusively as a research and infrastructure recipient under federal grant programs.

NYSBC's federal footprint is concentrated in research infrastructure and biomedical research training grants from the National Institutes of Health. The Department of Health and Human Services, National Institutes of Health, accounts for substantially all recent grant activity: the NIH Office of the Director, National Institute of Allergy and Infectious Diseases, National Institute of General Medical Sciences, and National Cancer Institute have issued the bulk of awards. Recent prime grants include a $3.678 million Research Infrastructure Programs (CFDA 93.351) award from the NIH Office of the Director in July 2026 for acquisition of a gyrotron system for dynamic nuclear polarization solid-state NMR spectroscopy; a $1.999 million Biomedical Research and Research Training grant (CFDA 93.859) from the same office in September 2026 for a Sirius XT SXT-100 soft X-ray microscope for the Simons Electron Microscopy Center (SEMC); a $1.97 million Research Infrastructure Programs award in June 2026 for Gatan BioContinuum energy filters for three Titan Krios G2 microscopes; and a $518,400 Allergy and Infectious Diseases Research (CFDA 93.855) award from the NIH's National Institute of Allergy and Infectious Diseases in July 2025 for structural characterization of a viral internal ribosome entry site from Giardia lamblia virus. NYSBC also operates the National Center for cryo-EM Access and Training (NCCAT) under a multi-year center grant from the NIH National Institute of General Medical Sciences (CFDA 93.859, award date July 1, 2024, ultimate completion August 31, 2029) and the RM1 Center on Macromolecular Dynamics by NMR Spectroscopy (COMD/NMR), a biomedical technology development and dissemination center at the same institute (award date July 1, 2022, completion May 31, 2027).

The Center operates the Simons Electron Microscopy Center as the core delivery vehicle for cryo-EM access and training. SEMC houses nine Titan Krios 300-kilovolt transmission electron microscopes, four 200-kilovolt Glacios microscopes with direct detectors, three cryo-focused ion beam microscopes, and ancillary sample-preparation and data-processing equipment, providing on-site, remote-access, and mail-in data collection services alongside comprehensive training in cryo-EM workflows to a nationwide user base of NIH-funded researchers. NYSBC's NMR infrastructure includes spectrometers at 700, 800, and multi-field magnetic strengths equipped with modern solid-state and solution-phase probes, dynamic nuclear polarization equipment, high-pressure measurement capability, and field-cycling relaxometry systems. The Center delivers technical support and methodology training in spin-relaxation methods, structural and dynamics analysis, and advanced NMR pulse sequence development.

NYSBC also acts as a sub-recipient on research grants. Across recent sub-award activity, NYSBC provides structural biology expertise and infrastructure access as a named subgrantee on projects anchored at Rutgers University (small-molecule inhibitors targeting ricin and Shiga toxin ribosome binding sites), the University of Colorado (self-cleaving peptides mechanisms across eukaryotic species), and Virginia Commonwealth University (streptococcal membrane protein characterization). The source identifies nine awards with ultimate completion inside the next twenty-four months, representing recompete opportunity for renewal or expansion of center operations and infrastructure grants. NYSBC does not hold federal contracts, GWACs, BPAs, or commercial service contracts of note in the Service Contract Inventory dataset; its federal footprint is exclusively research and infrastructure grants issued through the NIH.