Reaction Biology Corporation
Malvern, PA
- UEI
- LDBCLKM4WJH1
- CAGE
- 486T0
- Primary NAICS
- 541380 Testing Laboratories and Services
- SAM.gov registration
- Active through
Company facts
- Self-certified in SAM.gov
- Entity structure
- Corporate Entity (Not Tax Exempt)
- Other NAICS codes in SAM.gov
- SAM.gov registration date
- Physical address
- 1 Great Valley Pkwy #2, Malvern, PA 19355, USA
- Website
- reactionbiology.com
- Founded
- 2001
- Employees
- 51-250
- Estimated annual revenue
- $10M-$50M
- Industry
-
- Industrials
- Commercial & Professional Services
- Professional Services
- SIC code
- 87 Engineering & Management Services
Registration and certifications come from SAM.gov and the SBA; company details from public web sources. Updated .
Contract obligations by fiscal year
| Fiscal year | Obligated |
|---|---|
| FY2027 To date | $0 |
| FY2026 | -$2,893 |
| FY2025 | $59,768 |
| FY2024 | $125,822 |
| FY2023 | $140,689 |
Contract awards
Latest 5 listed here. See the rest on GovTribe.
Grant awards
Latest 5 listed here. See the rest on GovTribe.
Similar vendors
| Vendor | Location | Primary NAICS |
|---|---|---|
| BPS Bioscience Inc. | San Diego, CA | 541714 Research and Development in Biotechnology (except Nanobiotechnology) |
| QPS LLC | Newark, DE | 541714 Research and Development in Biotechnology (except Nanobiotechnology) |
| Biotesting Division | Plainsboro Center, NJ | 541714 Research and Development in Biotechnology (except Nanobiotechnology) |
| Opans LLC | Durham, NC | 541380 Testing Laboratories and Services |
| Ampseq LLC | Gaithersburg, MD | 541380 Testing Laboratories and Services |
About the company
Reaction Biology Corporation is a self-certified small disadvantaged business and contract research organization headquartered in Malvern, Pennsylvania, with additional laboratory facilities in Maryland. The company specializes in providing advanced biochemical and preclinical research services to support translational science initiatives across the National Institutes of Health and its various institutes and centers. Reaction Biology has established itself as a key provider of enzyme activity assays, screening services, and related laboratory testing that enables biomedical researchers to characterize potential therapeutic compounds and elucidate drug mechanisms of action. The company operates proprietary screening platforms including Kinase HotSpot and Methyltransferase HotSpot assays that facilitate comprehensive enzymatic testing for novel small molecules and other drug candidates.
Reaction Biology Corporation has received a consistent stream of firm fixed-price purchase order contracts from the National Center for Advancing Translational Sciences (NCATS), the National Institute on Drug Abuse (NIDA), and the Office of Logistics and Acquisition Operations, with contract values ranging from $11,304 to $166,500. The company's federal contract work has primarily involved kinase inhibition testing and profiling services, including Gamma 33P ATP kinase assays and NanoBRET kinase assays conducted across varying numbers of wild-type kinase panels and novel small molecule compounds. Notable projects include testing 370 wild-type kinase enzymes, screening 377 kinases against 10 compounds, profiling 10 BTK inhibitors versus a 20-kinase panel, and characterizing dose-response relationships for hundreds of test compounds. In addition to kinase assays, Reaction Biology has provided methyltransferase panel screening services using its proprietary Methyltransferase HotSpot platform, cell profiling services, and cellular NanoBRET assays to support cancer research, COVID-19 research initiatives, and other translational science projects. All contracts were awarded without small business set-aside designations, with many structured as sole-source awards justified by the requirement for data consistency, methodology continuity, and the company's specialized technical capabilities in maintaining comparable sample analysis throughout ongoing research projects.
Quick answers
Is Reaction Biology Corporation registered in SAM.gov?
Yes. Reaction Biology Corporation's SAM.gov registration is active through March 2, 2027.
What is Reaction Biology Corporation's CAGE code?
Reaction Biology Corporation's CAGE code is 486T0, and its Unique Entity ID (UEI) is LDBCLKM4WJH1.
How much has Reaction Biology Corporation received in federal contracts?
Federal contracts obligated $59,768 to Reaction Biology Corporation in fiscal year 2025 and $323,386 in fiscal years 2023 through 2027.
What is Reaction Biology Corporation's most recent federal award?
Reaction Biology Corporation's most recent federal contract award is Bioactive small molecule development project - gamma 33P ATP kinase assay and nanobret kinase assay (140D0425P0049), from Interior Business Center (DO), on September 19, 2025.
On GovTribe
See Reaction Biology Corporation's full federal record
- Federal contract awards
- Federal grant awards
- Funding analysis by agency, NAICS and set-aside
- Similar vendors