Cayuse Holdings LLC

Cayuse Holdings LLC, doing business as Cayuse, is a for-profit limited liability company headquartered in Portland, Oregon, that specializes in cloud-based enterprise software solutions for research administration and compliance. The company develops and delivers specialized software platforms and modules designed to streamline administrative processes, protocol management, and regulatory compliance for universities, hospitals, and government agencies. Since its registration in SAM.gov in May 2019, Cayuse has established a robust portfolio of federal contract awards, positioning itself as a trusted technology partner for federal research institutions seeking to modernize their research administration operations.

Cayuse's federal contract work spans multiple software products and services delivered to diverse civilian and defense agencies. The company's primary offerings include the Cayuse Vivarium software platform for Institutional Animal Care and Use Committee (IACUC) management and vivarium operations; the ESIRIUS Facility Management Software System for animal facility resource management; the iRIS software suite for research compliance and management; and various IRIS IRB Assistant Enterprise Compliance modules for institutional review board support. Cayuse has secured contracts from the National Institutes of Health components including the National Institute of Environmental Health Sciences (valued at $274,873.71 and $228,768.38), National Institute on Drug Abuse ($444,784.89), National Cancer Institute ($185,606.54), National Institute of Standards and Technology ($196,669.44), the Smithsonian Institution Office of the Chief Information Officer (multiple awards totaling over $65,700), West Point Military Academy ($52,319.49), the Department of Veterans Affairs ($120,735.00), the Department of Agriculture Wildlife Services ($235,896.58 under a Total Small Business set-aside), and the National Institute of Neurological Disorders and Stroke ($20,160.00). These purchase order contracts, which typically range from $14,300 to $444,784.89 with performance periods extending 3 to 5 years, are predominantly firm-fixed-price arrangements with no set-aside designations, except for the Wildlife Services contract. The contracts frequently include option periods for renewal and represent sole-source awards, particularly for NIEHS, reflecting federal agencies' determination that Cayuse represents the only responsible source capable of meeting their specialized research administration software requirements.