Cayuse Holdings LLC

Cayuse Holdings LLC, doing business as Cayuse, develops and sells cloud-based research administration and compliance software to federal agencies as a 100% prime contractor, competing full-and-open with no set-aside posture except for a single Total Small Business award. The Portland, Oregon-based for-profit limited liability company specializes in software licensing, maintenance, and support for institutional review boards, animal care and use committees, facility management, and research protocol administration across civilian science agencies. NAICS coding runs primarily to Software Publishers (NAICS 513210) with PSC designation 7A21 (IT and Telecom—Business Application Software).

Cayuse's federal revenue concentrates heavily in research-intensive NIH components and Veterans Affairs. The National Institute of Environmental Health Sciences represents the largest customer by combined potential value at $574 thousand across three awards, followed by the National Institute of Neurological Disorders and Stroke at $403 thousand, and the Department of Veterans Affairs Technology Acquisition Center at $351 thousand. These three customers alone account for 78% of Cayuse's combined potential value. The Smithsonian Institution Office of the Chief Information Officer leads by award count at four orders but carries only $86 thousand in combined potential value — a signal of small, recurring maintenance contracts rather than platform expansion work. Nine distinct customer agencies are active in the footprint, with the top five accounting for 74% of awards.

Concrete capability work spans research compliance platforms and facility management systems. Representative examples include a $383 thousand firm fixed-price purchase order from the National Institute of Neurological Disorders and Stroke (September 2022, completion September 2027) for Cayuse ESIRIUS Facility Management Software System maintenance and support for vivarium resource management; a $274 thousand purchase order from the National Institute of Environmental Health Sciences (January 2026, completion December 2028) for Cayuse Vivarium software licenses supporting animal oversight and veterinary care; and a $230 thousand sole-source SDVOSB definitive contract from the Department of Veterans Affairs Technology Acquisition Center (August 2026, completion December 2030) for iMedRIS Integrated Research Information System software maintenance covering the Institutional Review Board, Institutional Animal Care and Use Committee, and other compliance committees across multiple VA sites since 2012. A $236 thousand Total Small Business purchase order from the Department of Agriculture's Wildlife Services (January 2023, completion April 2027) modernized the National Wildlife Research Center's research protocol and study-related processes.

Activity has declined materially. Cayuse recorded five awards in 2022, six in 2023, two in 2024, one in 2025, and three in 2026 — a downward trajectory with only three awards (combined potential value $816 thousand) reaching ultimate completion in the next twenty-four months, creating moderate recompete exposure. The vendor does not subcontract; all 19 awards are prime work. Combined potential value across all awards stands at $2.3 million, with $1.4 million obligated to date (64% of potential value). The company operates solely on individual purchase orders and definitive contracts — no government-wide vehicles, BPAs, or IDIQs — meaning each task requires a fresh solicitation and award. Cayuse competes on sole-source and competitive full-and-open basis; it holds no standing federal contract vehicles and therefore cannot respond to task-order competitions without new solicitation and award.