Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trials Not Allowed)

Closed Posted

Opportunity number
RFA-ES-25-003
Agency
Applications due
Award size
Up to $800,000

Opportunity facts

Funding instrument
Grant
Categories
  • Education
  • Environment
  • Health
Eligible applicants
  • City/Township Governments
  • State Governments
  • Tribal Governments (Federally Recognized)
  • Higher Education Inst. (Private)
  • Tribal Organizations (Not Federally Recognized)
  • Higher Education Inst. (Public)
  • Independent School Districts
  • Other
  • 501(c)(3) Nonprofits
  • Non-501(c)(3) Nonprofits
  • Special District Governments
  • For Profit Organizations
  • Public or Indian Housing Auth.
  • County Governments
  • Small Businesses
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

This Notice of Funding Opportunity (NOFO) from the National Institutes of Health (NIH) seeks to support novel environmental health research that takes advantage of a limited window of opportunity to collect critical data in response to unpredictable events or policy changes. The R21 grant mechanism (Clinical Trials Not Allowed) will provide rapid funding and review, with the entire cycle from submission to award expected to take only 4-6 months. Eligible applicants include higher education institutions, government entities, tribal organizations, nonprofits, and small businesses. The research must address time-sensitive questions related to natural or human-made disasters, emerging environmental public health threats, and policy changes in the U.S. and abroad.

The program falls under two CFDA numbers: Environmental Health (93.113) and NIEHS Superfund Hazardous Substances Basic Research and Education (93.143). Award values are not specified, but typical grants in these programs range from $200,000 to $4 million. Research is expected to be conducted at the recipient institutions across the United States. The application deadline is December 1, 2025.

Synopsis

This Notice of Funding Opportunity (NOFO) is intended to support novel environmental health research in which an unpredictable event or policy change provides a limited window of opportunity to collect human biological samples or environmental exposure data. The primary motivation of the NOFO is to understand the consequences of natural and human-made disasters, emerging environmental public health threats, and policy changes in the U.S. and abroad. A distinguishing feature of an appropriate study is the need for rapid review and funding, substantially shorter than the typical NIH grant review/award cycle, for the research question to be addressed and swiftly implemented. The shortened timeframe will be achieved by more frequent application due dates and expediting peer review, council concurrence and award issuance. The entire cycle, from submission to award, is expected to be within 4-6 months.

Files

File Type Posted
RFA-ES-25-003-Full-Announcement.html HTML file

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