HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)

Open Posted

Opportunity number
RFA-AT-25-003
Agency
Applications due
Award size
Up to $375,000

Opportunity facts

Funding instrument
Grant
Categories
  • Income Security and Social Services
  • Health
Eligible applicants
  • Higher Education Inst. (Private)
  • Other
  • Higher Education Inst. (Public)
Points of contact
Full announcement

Opportunity details come from Grants.gov. Updated .

About this opportunity

Written by GovTribe AI ·

The National Institutes of Health is soliciting applications for the HEAL Initiative: Pain Research Enhancement Program (PREP) to support rigorous basic and mechanistic pain research conducted by R15-eligible Principal Investigators, with applications due November 23, 2026.

Eligible applicants are R15-eligible institutions, including public and private higher education institutions, Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs). Non-domestic entities and non-domestic components of U.S. organizations are ineligible; foreign components as defined in the NIH Grants Policy Statement are permitted. The program prioritizes integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, with active engagement of health professional trainees, undergraduate, and graduate students in proposed pain research projects.

This opportunity operates under seven Assistance Listings: Arthritis, Musculoskeletal and Skin Diseases Research (93.846); Alcohol Research Programs (93.273); Child Health and Human Development Extramural Research (93.865); Oral Diseases and Disorders Research (93.121); Extramural Research Programs in the Neurosciences and Neurological Disorders (93.853); Research and Training in Complementary and Integrative Health (93.213); and Aging Research (93.866). Applications undergo standard NIH peer review, with evaluation based on scientific merit, technical adequacy, investigator competency, adequacy of facilities and resources, budget justification, and relevance to announced program objectives. Clinical trials are optional.

Synopsis

The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs) ; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Files

File Type Posted
RFA-AT-25-003-Full-Announcement.html HTML file
PKG00289965.pdf PDF

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