RFA-AT-25-003-Full-Announcement.html

This is a Request for Applications (RFA) document from the Department of Health and Human Services National Institutes of Health for the HEAL Initiative: Pain Research Enhancement Program (PREP) under solicitation RFA-AT-25-003. The opportunity is for R15-eligible Principal Investigators to conduct basic and mechanistic pain research projects, targeting higher education institutions (both public and private).

The initiative operates under multiple federal grant programs, including Arthritis Research (93.846), Alcohol Research (93.273), Child Health Research (93.865), Oral Diseases Research (93.121), Neurosciences Research (93.853), Complementary Health Research (93.213), and Aging Research (93.866). The program aims to promote interdisciplinary research partnerships between R15-eligible PIs and other U.S. institutions, while enhancing the pain research environment for health professional trainees and students through active engagement in research projects. This is designated as a civilian grant opportunity with clinical trials being optional.