Whole brain mouse light sheet brain imaging service
Closed Pre-Solicitation Posted
- Solicitation number
- 75N98026Q00887LIFECANVASTECHNOLOGIESINC
- Agency
-
Office of Logisitics and Acquisition Operations
National Institutes of Health, Department of Health and Human Services
- Responses due
- Set-aside
- No set-aside
Opportunity facts
- NAICS code
- Not on record
- PSC
- 6505 Drugs And Biologicals
- Place of performance
- Bethesda, Maryland 20892, United States
- Points of contact
Notice details come from SAM.gov. Updated .
About this opportunity
The National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism (NIAAA) intends to solicit whole brain mouse light sheet brain imaging services with a response deadline of August 5, 2026. This is a firm fixed-price purchase order for the period July 2026 through July 2027.
The contractor will process brain tissue samples from genetically modified mouse lines maintained by NIAAA's Section on Neural Circuits. Samples arrive shipped in tubes and require tissue clearing, whole-brain light-sheet imaging, and segmentation into over 820 anatomical regions. The contractor must generate CVF files containing both raw cell counts and counts normalized per area, transfer results to NIH-supplied hard drives, and maintain archived data and physical samples for a minimum of one year to permit retesting. Results must be delivered within one month of sample arrival, a requirement driven by age-sensitive experiments that depend on rapid turnaround for validity.
The contractor receives and logs incoming samples, performs tissue preparation, conducts imaging, segments brains into defined anatomical regions, and generates standardized output files. The NIAAA's Lead Project Manager and trainees in the Section on Neural Circuits collect the brain tissue samples. Work is performed at the contractor's facility. The PSC code is 6505 (Drugs and Biologicals). No set-aside is anticipated.
Notice text
The imaging service will be used to analyze changes in whole brain activity from genetically modified mouse lines maintained by the Section on Neural Circuits at the NIAAA, NIH. Accurate imaging of brain activity is essential it forms the foundation for all downstream experimental analyses. Without this information, we cannot proceed with our experiments, as the validity of our data depends on the ability to quantify phenotypic differences based on genotype.
Rapid turnaround is also critical, as some experiments are age-sensitive and require genotyping results within 1 month of sample receipt. The brain tissue samples to be processed by clearing and light sheet imaging will be collected by the Lead Project Manager (LPM), and trainees in the Section on Neural Circuits at the NIAAA.
Whole brains are shipped to the company in tubes. The company processes the samples by clearing the tissue and performing light-sheet imaging. The brain is segmented into over 820 regions, and CVF files containing both raw counts and counts per area are provided. Results must be delivered within one month of sample arrival. Data are shipped to us on an NIH-supplied hard drive, and both the results and brain samples are retained by the company for at least one year to allow for any necessary retesting.
The following tasks are required to fulfill this requirement:
Receive and log incoming brain samples.
Perform tissue clearing and prepare samples for imaging.
Conduct whole-brain light-sheet imaging.
Segment the brain into defined anatomical regions (>820 areas).
Generate CVF files with raw and normalized cell counts.
Transfer data to an NIH-provided hard drive and ship to the research team.
Maintain archived data and physical samples for a minimum of one year.
Files
| File | Type | Posted |
|---|---|---|
| Statement of Work SOW - LifeCanvas Technologies Laboratory Testing Services.docx | DOCX document |
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